Tarek M. Ashkar (El-Achkar)

Physician Scientist, Nephrologist. Interests: #AKI, #Uromodulin, Multiplex imaging & Spatial analytics, Immune mediated kidney injury. Investigator @KPMProject

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Happy to contribute along with many other colleagues to the 2 Kidney papers bridging @KPMProject and @_hubmap that are just out today in @Nature and @NatureComms :
https://t.co/baE86iHfKE
https://t.co/Xom4i9Y8lD

[ASN Publications @asnpublications]

Kidney casts contain high levels of PROM1, a marker linked to cell damage and dedifferentiation based upon new #ASNCJASN study. https://t.co/G3LaMD65Hh

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Registration link

https://t.co/EeO1lWje0p

Preliminary agenda

https://t.co/kf8xz11rcn

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Save the Dates: May 20 & 21, 2026
The Indiana O’Brien Center for Advanced Renal Microscopy will host a virtual workshop on Spatial Protein Imaging. Details coming soon on the program and registration (free). Stay tuned!!

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Save the Dates: May 20 & 21, 2026
The Indiana O’Brien Center for Advanced Renal Microscopy will host a virtual workshop on Spatial Protein Imaging. Details coming soon on the program and registration (free). Stay tuned!!

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

@Carmendemigue12 @KidneyInCVD Thank you so much Carmen! So kind of you. Big kudos to all the team, but especially Azuma Nanamatsu who has been the driving force behind this work.

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

What proteins do kidney tubular casts contain? More than what you think but with notable absences. New in CJASN https://t.co/NgvPDvHlxh

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

The secret of youth: posting a profile picture on the university website. Diamonds are forever.

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Times have changed. Reviewing papers stopped being predominantly a duty and an academic privilege, to also becoming an integral part of a multi-billion dollar publishing industry. Compensate reviewers? Any other examples of industry sustained by free work?

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

The Role of the Vascular Niche in Regulating Kidney Tubulo-Interstitial Fibrosis - Kidney International https://t.co/WToxGTWRfH

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

This perspective in ⁦⁦@asnpublications⁩ CJASN discusses the importance of spatial biology in studying kidney disease and the translational implications to identify therapeutic targets and biomarkers. https://t.co/ZjINVRGkGM

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Happy to contribute to this superb work!

[ASN Publications @asnpublications]

The lymphatic system has historically been understudied due to the difficulty of distinguishing it from the blood vasculature. This #ASNKidney360 paper's authors optimized an antibody-based method for imaging hard-to-visualize adult murine kidney lymphatics. Read more: https://t.co/llmDQbxNC1

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Linking histology with Omics. Happy to contribute to this work that offers a really nice tool. ⁦@_hubmap⁩ https://t.co/NNdGg0Nu98

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Kudos to all the team @IUKidney and all the collaborators and especially the participant heroes from @KPMProject who made this work possible

[IU School of Medicine @IUMedSchool]

Kidney diseases are a leading cause of death in the U.S. They affect 14% of adults, often without knowing it. IU researchers are mapping kidney cell types to improve diagnosis and open the door to more precise therapies.

https://t.co/U4yksa5he9

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

@ivivek87 Thanks! Yes, there were intermediary states THY1+, PROM1+(and VCAM1+), but loss of THY1 and persistence of PROM1 seems to correlate with injury and maladaptive repair.

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Our latest in ⁦@ScienceAdvances⁩ from a large collaboration through ⁦@KPMProject⁩ . We characterize a population of PTs in human kidney that express the regenerative marker THY1. THY1+ PTs are lost in kidney disease https://t.co/7VRrhl8wp7

[ASCI @the_asci]

Kidney cells can protect themselves during injury, but the mechanisms were unclear.

ASCI member Tarek M. El-Achkar @AshkarLab & team @IUMedSchool now show that oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production.

View paper: https://t.co/Thtsvb6ZfZ

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Very nice excited to see this work published and also the super well done editorial by @Vishal_D_Patel

[Journal of Clinical Investigation @jclinicalinvest]

Kidney cells can protect themselves during injury, but the mechanisms were unclear.

@AshkarLab & team @IUMedSchool now show oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production.

View paper: https://t.co/346QR9uX7a

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Congratulations to Mike Eadon ⁦@EadonLab⁩ and Takashi Hato from ⁦@IUKidney⁩ for being inducted to ⁦@the_asci⁩ !!!!!

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

Looking forward to this tomorrow!

[Leica Microsystems @LeicaMicro]

How do trillions of cells work together to form & maintain the human body? @AshkarLab & @sarahteichmann1 will guide you through 3D & 4D spatial imaging, uncovering how organs function, develop, & respond to disease. Join the discussion! https://t.co/ICcapWU3kn #CellMapCrew