Ashwin Uday

Integrated PhD student
Indian Institute of Science Education and Research, Pune.
Exploring research and new paradigms.

[Ashwin Uday @AshwinUday22]

@BlueDart_ has been completely irresponsible in handling sensitive shipment containing my PhD research samples worth years of hard work. I have called and messaged a lot of officials and customer care, nobody seems to give a damn or even reply. AWB#58170889265. Last option. HELP

[RAMANUJAM SRINIVASAN @kuruhoornambi]

Nice :) scratching has anti-bacterial benefits...Why it feels good to scratch that itch: the immune benefits of scratching https://t.co/3gPx57cexC

[Notion @NotionHQ]

Let’s take a moment to revisit basics — a shortcut refresher to help you work faster in Notion 👇

[Deepak T. Nair @dtnair]

BamH1 exhibits changes in structure on DNA binding.
https://t.co/Bt7AXIyCSK

[Ashwin Uday @AshwinUday22]

@NMatange Congratulations...all the best for this Amazing responsibility

[TheLiverDoc™ @theliverdoc]

📣Sugar is more terrifying than alcohol 📢

Sugar does not come with labelled warnings
Consumption of sugar can start at any age
Sugar is available everywhere in many forms
Sugar comes hidden in many forms
People are often misled on "healthy sugars"
There is no stigma attached to sugar consumption

Sugar does to the liver what alcohol does too

From children to adults, "Sugar is the new Alcohol"

This beautiful review in @HepCommJournal on "sugar-related liver disease" is maddeningly important

The Impact and Burden of Dietary Sugars on the Liver: https://t.co/GknarRf9Lx

Non-alcoholic fatty liver disease or NAFLD (new term: metabolic-dysfunction related steatotic liver disease or MASLD) has multiple causes - BUT - the most important of those, is dietary intake of added sugars.

And the most dangerous of the lot?
Fructose - yes, not sucrose (or table sugar)

Glucose is metabolized by all cells in the body
Fructose is metabolized mostly in liver
Fructose is MORE lipogenic than glucose - meaning it can increase fat formation much higher than glucose inside the liver.

Fructose is particularly problematic since it is the sweetest tasting natural sugar, 1.2–2.0 times sweeter than table sugar. The consumption of fructose has increased by 30% in the last 40 years and by 500% over the last century due to the increased consumption of processed foods/sugar-sweetened drinks.

More fats form inside liver cells, liver cell function gets affected, inflammation inside liver starts, glucose sensitivity reduce, insulin secretion and resistance increase and more glucose forms leading to "hyperglycemia" (as seen in diabetes)

Added sugars in diet play central role in onset and progression of NAFLD.

Recommended intake of added sugars: <5% of total calorie intake! - i.e., 25g or 100 calories in a 2000 calorie per day diet.

Worst of the lot: SSBs or sugar-sweetened beverages, desserts and sweet snacks (bakery and confectionary) and honey - has sugars in form of sucrose, high fructose corn syrup and natural fructose.

Sugar affects body beyond liver too:
- In brain, triggering of reward pathway, promoting "pleasantly excessive" calorie intake - "cant stop eating sugary stuff" feeling - obesity!

- fructose increases appetite by increasing ghrelin (the "hunger" hormone) - "eat more sugar"

- added sugars have habit-forming properties similar to alcohol, tobacco, cocaine, and caffeine

- In muscle - increases muscle fat making muscles weaker and "low quality" - poor stamina/effort intolerance

- Increased risk of heart disease, high blood pressure, chornic kidney disease

Children (& adults) become unhealthy, have poor muscle quality, are more stressed, develop obesity, fatty liver disease and chronic liver disease, various metabolic illnesses, have high risk for cancers and have poor performance overall - just because of SUGAR.

But is all fructose bad? Like those in fruits?
No. Whole fruits contain fiber and antioxidants, which may protect against the harmful metabolic effects of sugar consumption - have whole fruits/ cut fruits rather than fresh juices or packaged fruit juices.

When children and adults go on a low added sugar diet, especially low fructose diet, liver functions, cardiac health, performance status, overall well being improves drastically.

Remember, sugar is the new alcohol, but without warnings.

[IISER Pune @IISERPune]

Dr. Gayathri Pananghat from #IISERPune is among recent awardees for S. Ramachandran National Bioscience Award from @DBTIndia!!
Dr. Pananghat's research is on understanding the molecular basis of cell shape and motility
Our #Congrats and best wishes!!
https://t.co/uuKi2ADvM0

[EMBL Events @EMBLEvents]

2024 is a special year – it marks 50 years of @embl! 🥳 We've got a fantastic programme lined up for you: https://t.co/2WvLBMkbz3
Check out our 2024 EMBL Annual Poster and mark your calendars, because we're already thrilled to see you here for new events like the @EMBO | EMBL Symposium 'AI and biology' and classics such as #EESRNA 👏🏽

[Akansha Ganguly @ganguly_akansha]

Food for thought.

[Ashwin Uday @AshwinUday22]

Liaisoning @g20org #G20India #G20Edu4all with @the_dope_drug and @itsmesonaaaa

[Ashwin Uday @AshwinUday22]

@LouisJeantetFDN @UNIGEnews @TheCrick @CramerLab @mpi_nat I am Ashwin, doing my PhD from IISER Pune, India. How to apply and join?
Thanks

[Ashwin Uday @AshwinUday22]

@ManeshJoshi1 @IISERPune @COoLLabSR @patankar_lab Congratulations Manesh, really happy and proud

[Ashwin Uday @AshwinUday22]

Excited to see @JungmannLab at @MPI_Biochem breaking the barriers with super resolution fluorescence microscopy.

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Ångström-Resolution Fluorescence Microscopy:
@JungmannLab develops RESI, which resolves the distance between individual DNA bases and determines the structural basis of anti-CD20 immunotherapy.
@Nature @LMU_Muenchen

➡️https://t.co/8MqthRM8rt
➡️https://t.co/KCO302u9Tl

[Ashwin Uday @AshwinUday22]

@Marvel_India Never fall in love again until I found you...😜

[Hasan Toor @hasantoxr]

3. SciSpace Copilot

SciSpace Copilot gives you real-time answers to articles, no matter where you read them online.

Take your AI research assistant wherever you go with this all-new AI Chrome extension.

https://t.co/FSdMMav6Qv

[Manesh Joshi @ManeshJoshi1]

Delighted to share that the final part of my Ph.D. work with @COoLLabSR and @AshwinUday22 has now been published in @CommsChem @SpringerNature.
We thank @IISERPune and @serbonline for all the funding and support.

Here is the link for the paper:
https://t.co/gAssDEBtcD
(1/5)

[iGEM IISER Pune @igem_iiserpune]

We have amazing news!

We could not have done this without the help from our mentors, sponsors, volunteers and supporters and the previous year's iGEM team who have been with us throughout our journey.
Thank you!

Congratulations to all the participating teams!

[Subhojit Roy, MD, PhD @Roy_Lab_Thinks]

My lab will be hiring at all levels soon - postdocs, senior scientists, technicians. Please send your CV if interested (https://t.co/lqkz2lqeOb). Projects centered around gene therapies in neurodegeneration, particularly Parkinson's disease.

Please RT.

[Los Angeles Times @latimes]

#AvengersCampus, opening Friday in Anaheim, boasts a new interactive ride and a glossy, silver airship.

But what truly contrasts it with others in the #Disney parks is its devotion to theater, embrace of the present &amp; lack of fear of the “real world” https://t.co/LBWjg6aUgx