Aurelien Justet

[James D Chalmers @ProfJDChalmers]

Congratulations also to the other journals in the ERS family all of which have increased their impact factor this year

ERJ 23.8
ERR 10.8
Breathe 4.5
ERJ Open 4.4

@ERSpublications

[Naftali Kaminski @KaminskiMed]

Grateful to all the amazing people who worked on this manuscript, it is a true multi-national, multi-institutional effort, especially @AurelienJustet, Venerino Poletti, Claudia Ravaglia, Ivan Rosas, Sarah Tomasetti and their teams
#CollaborationMatters
https://t.co/Fuv5Yvqa7p

[Naftali Kaminski @KaminskiMed]

The paper has been submitted for #PeerReview, but knowing how long it takes to get a paper out, we decoded to share it early, to inform & inspire others, the #PFWarrior and #CurePF4All communities
We hope, with review it gets better
#PreprintsMatter https://t.co/yyX28bn7D2

[Naftali Kaminski @KaminskiMed]

But most important is our finding that, not unlike early-stage cancer, the molecular and cellular hallmarks of IPF, a LETHAL disease, occur before loss of pulmonary functions or symptoms, highlighting the urgent need for early detection
#EarlyIPFIsIPF
https://t.co/yyX28bn7D2

[Naftali Kaminski @KaminskiMed]

There are also interesting findings regarding fibroblast, endothelial, immune cell populations
https://t.co/yyX28bn7D2

[Naftali Kaminski @KaminskiMed]

snRNASeq of Early IPF lungs reveals emergence of aberrant basaloid cells & alveolar intermediate epithelial states & marked loss of AT2 and AT1 cells in early IPF.
These changes associate with subsequent disease progression 🙀
#EarlyIPFisIPF
https://t.co/yyX28bn7D2

[Naftali Kaminski @KaminskiMed]

The first snRNASeq & spatial transcriptomic analysis of bronchoscopic cryobiopsies from patients with Early IPF & preserved pulmonary functions is out on @biorxivpreprint and message is Early IPF is IPF‼️
https://t.co/yyX28bn7D2

[Yale PCCSM @YalePCCSM]

🤩🤩Another #YaleGreatTalk by @KaminskiMed lab superstar Dr. Abu Hussein 🤩🤩
#WeAreProud #ATS2026 #YalePCCSM #KaminskiLab
👇👏👏👇

[Aurelien Justet @AurelienJustet]

Outstanding presentation by Jannik Ruwisch unveiling a multicenter, multi-organ spatial atlas of granulomas. A remarkable effort toward building a blueprint of granuloma, revealing conserved cellular niches, tissue organization, and immune interactions #ATS2026

[ATS_Assemblies @ATS_Assemblies]

Congratulations to the recipient of the @ATS_GG Early Career Investigator Achievement Award Jonas C. Schupp, MD, MPVD, ATSF @jonas_schupp

Learn more at: https://t.co/c4ejsXgOi7

[Naftali Kaminski @KaminskiMed]

Congratulations to Jonas Schupp recipient of the #ATS2026 @ATS_GG Early Career Investigator Achievement Award 🎉!!! This award honors early career investigators with outstanding contributions to genetics, genomics, omics & systems biology of lung diseases
https://t.co/QwWgRSRxCm

[Jonas Schupp @jonas_schupp]

Huge thanks to our binational team, all patients who donated tissue, and our collaborators across Hannover, Paris, Leuven, London & Yale

Let by fantastic @Jannik_Ruw @AurelienJustet, #NotOnTwitter Aurélie Cazes, Lena Leiber, & amazing mentor support @KaminskiMed @bruno_crestani

[Jonas Schupp @jonas_schupp]

WORKING MODEL: Inflammation hits loose connective tissue fibroblasts → they recruit lymphocytes via CXCL12/13 → TLS form → TGFB1 drives adventitial→elastofibrotic→CTHRC1+ transition → alveolar filling + epithelial dedifferentiation → usual fibrotic niche propagates inward.

[Jonas Schupp @jonas_schupp]

TWEETORIAL | We mapped PPFE at single-cell resolution — and found an unexpected blueprint for lung fibrosis. A thread on our new paper in @ScienceAdvances https://t.co/5B0D2Num8B

Data live at https://t.co/VHDwQlCikP

[Naftali Kaminski @KaminskiMed]

Finally out!! The first single cell atlas of Pleuroparenchymal fibroelastosis (PPFE), a lethal, poorly understood lung disease that predominantly affects females. Kudos to Drs Ruwisch, Justet, Schupp & team for this groundbreaking effort!!!
#ATS2026 https://t.co/TTByYEnQAZ

[Aurelien Justet @AurelienJustet]

Children's respiratory health risks in the Gaza war: a call to act - The Lancet Respiratory Medicine https://t.co/GK8uZ3l2Xz

[Jonas Schupp @jonas_schupp]

This work was only possible through close collaboration across human genetics, pediatric pulmonary medicine, and adult pulmonary medicine. Questions none of us could have answered alone, solved together.

#BetterTogether #PPFE #RareDisease #LungFibrosis #Mitochondria

[Jonas Schupp @jonas_schupp]

Mitochondrial dysfunction as a primary, causal driver of PPFE pathogenesis: EM revealed severely altered mitochondrial ultrastructure in Aberrant Basaloid cells, with loss of matrix and cristae degeneration - providing the structural basis for disease through ROS

[Jonas Schupp @jonas_schupp]

We, Sandra von Hardenberg, Nicolaus Schwerk, and Pia Maier and more, are super enthusiastic about our new preprint!:

Pleuroparenchymal fibroelastosis in monogenic DGUOK-associated mitochondriopathy

https://t.co/4oMwwsopen

[Pradeep Natarajan @pnatarajanmd]

Our manuscript led by @NakaoTetsushi @skoyamamd - a comprehensive characterization of leukocyte telomere length (LTL), a hallmark of biological aging across the US https://t.co/QG9T8XixWZ @NatureGenet
Quick summary of lessons learned: