Auron Health

🧬 Longevity news, made simple
🔬 New studies, products & clinics
💪 Fitness, diet & healthy aging
😊 The science of a happy life

[Auron Health @Auronhealth]

Trouble sleeping? Andrew Huberman @hubermanlab says keep your bedroom cool, drop it a few degrees, and layer blankets as needed. Too warm? Stick a foot out.

Full ep: https://t.co/bopKzhopqh
Clip © Scicomm Media LLC

#longevity #podcast

[Auron Health @Auronhealth]

@PeterDiamandis A 2000 study in Occupational and Environmental Medicine put a number on it: after 17 to 19 hours awake, people did as badly on some reaction and vigilance tests as they did at a 0.05% blood alcohol level, with responses up to 50% slower.

[Auron Health @Auronhealth]

@AgingBiology Worth knowing who it was tested on: the survival model was trained on about 34,000 photos of cancer patients, and the highest-risk quarter had over 3 times the mortality of the lowest. Whether a selfie can flag risk in healthy people is still untested.

[Auron Health @Auronhealth]

@bryan_johnson Jumping is a smart thing to train. In a Berlin study of 318 adults, jump power started dropping in the 20s and fell about 3.5% a year after 70, faster than strength or muscle mass.

[Auron Health @Auronhealth]

@bryan_johnson In the PEARL trial, a year of 5 or 10 mg weekly rapamycin in healthy adults didn't move visceral fat, the main outcome, though women on 10 mg gained some lean mass and reported less pain. Looked safe, but the healthspan payoff in people is still unproven.

[Auron Health @Auronhealth]

Flossing at all was linked to about a 30% lower risk of death in a study of 10,609 US adults 🦷

Daily flossers: about 32% lower. It's observational, so flossers may just be healthier overall… still, it's a cheap habit to keep.
https://t.co/86QpHQhauN
#longevity #oralhealth

[Auron Health @Auronhealth]

@AgingBiology Interesting detail: the aged mice got heat-killed bacteria, so the benefit may come from what the microbe makes rather than the live bug. In people this is still an association, with the lifespan gains shown only in worms so far.

[Auron Health @Auronhealth]

@foundmyfitness The meals here were matched within 1.6% on calories, macros, fiber, sodium and even glycemic index, so the extra insulin is hard to pin on anything but the processing. It was one ~300 calorie meal in healthy-weight adults though, so long-term effects are still open.

[Auron Health @Auronhealth]

@EricTopol @AnnalsofIM Interesting that the misses leaned toward overtesting, 5.4% vs 0.6% for wrongly holding back. ECGs before low risk surgery are one of the classic Choosing Wisely examples, so that's a familiar habit to see show up.

[Auron Health @Auronhealth]

@DrGJMurphy A lot of standard 1,000 mg softgels only carry about 300 mg of EPA plus DHA, so people can end up taking a third of what they think. The per serving amounts on the back label are what count.

[Auron Health @Auronhealth]

@biogerontology About one candidate a month is wild throughput. The real scoreboard will be how many make it through Phase 2, since that's where most drugs fall off.

[Auron Health @Auronhealth]

@AgingBiology Naked mole-rats can live more than 30 years, versus about 3 for a lab mouse of similar size, so a gap-free genome should make it much easier to find what's behind that.

[Auron Health @Auronhealth]

@riglesiamd Worth knowing that "ever smoked" in the USPSTF guidance means 100 or more cigarettes in your lifetime, so plenty of people who only smoked for a few years still qualify.

[Auron Health @Auronhealth]

@EricTopol @LancetDigitalH The lifestyle signal was a nice touch, with current smokers' faces reading older than former smokers', and former smokers older than never-smokers. Pretty striking that the highest risk quarter had over 3 times the death rate of the lowest from one photo.

[Auron Health @Auronhealth]

@nicknorwitz Ezetimibe working on cholesterol absorption in the gut instead of synthesis in the liver is what makes it such a neat fit for this question. A matched study tracking RER and ketones in statin users vs non-users over the first few weeks of carb restriction sounds very doable.

[Auron Health @Auronhealth]

@PeterDiamandis Getting up off the floor has real data behind it too. In a 2012 study of about 2,000 adults aged 51 to 80, the people who scored lowest on a sit-to-rise test had a 5 to 6 times higher risk of dying over the next 6 years than the top scorers.

[Auron Health @Auronhealth]

@bryan_johnson The Phase 3 only had a placebo arm, which gained 6.6 hairs/cm² at 6 months, so nobody has tested it head to head against plain generic oral minoxidil yet. That's the trial that would actually settle it.

[Auron Health @Auronhealth]

Those numbers come from one Finnish study of 2,315 men aged 42 to 60, followed for about 20 years. Only 201 of them used the sauna 4 to 7 times a week, and it's observational, so it shows a link, not proof that sauna adds years. #longevity

[Dr. Rhonda Patrick @foundmyfitness]

Sauna is my number one longevity intervention after exercise and diet.

A lot of what happens in the sauna overlaps with what happens during exercise, and sauna can even add to the benefits you’re already getting from exercise, including bigger gains in aerobic fitness and reductions in blood pressure.

Then there’s the long-term data - using the sauna 4 to 7 times weekly is associated with a 40% lower risk of all-cause mortality, a 50% lower risk of cardiovascular-related death, and up to a 66% lower risk of dementia and Alzheimer's disease.

Combined evidence from the physiology, exercise trials, and long-term data is a big part of why I take deliberate heat exposure seriously (and why you should too).

[Auron Health @Auronhealth]

This recall is 22 vials of compounded tirzepatide from one pharmacy, Apothecary Pharma, pulled for lack of assurance of sterility. It isn't Lilly's Zepbound or Mounjaro. If you use compounded GLP-1s, check for lots AP-202622 to AP-202644. #longevity

[Eric Topol @EricTopol]

National recall of GLP-1 drug (tirzepatide) made by a US compounding pharmacy because it puts patients at risk, according to FDA
https://t.co/jd5Gjdmbac

[Auron Health @Auronhealth]

A pill for male pattern hair loss added 36.4 hairs per cm² in 6 months vs 6.6 on placebo, in a 536-man Phase 3 trial.

It's Veradermics' extended-release oral minoxidil. Company topline data, not peer reviewed or FDA approved yet.
https://t.co/i1U3yTgDWi
#longevity #hairloss