Austin Newsam

MD-PhD student @umiamimedicine - @SchatzLabMiami // husband to @mbtnewsam // dad || grace perfects nature

[Blood Cancer Discovery @BCD_AACR]

Now online: In Vivo CAR T-cell Therapy: Determinants of Response and Durability https://t.co/uBHvmefOv9

[Florida Society of Pathologists @FLPathologists]

Registration is officially open for FSP’s 53rd Annual Pathology Conference, taking place Feb. 12-14, 2027, at Disney’s Grand Floridian Resort & Spa. 🔬

Physicians save $50 with early bird pricing. Full details here: https://t.co/Vfb9NUOdGp

#Pathology #FSPAnnual2027

[Austin Newsam @AustinNewsam]

@drjgauthier @JGrenierMDPhD @DrFredLocke Yes great point! Our collaboration is actively investigating this for bispecific responses as well.

[Jordan Gauthier @drjgauthier]

Strong data from @DrFredLocke lab et al supporting what was up to now only intuited; namely, that non-engineered endogenous T cells contribute to CD19 CAR T efficacy. Loss of MHC-I was identified as a key resistance mechanism.
Should we look at this more systematically in the post-CAR relapse setting? 😉 Does it also predict response to bispecifics?
#ASH25 #CARTx #lymsm

[Austin Newsam @AustinNewsam]

@tangming2005 This is so important. Key part = IN PERSON. Not a zoom. Face to face, working together. Even sitting side by side while code is being ran. This is the best (only) way I made progress working with my bioinformatition. Ty for this thread!

[David Usharauli @3DiMMUNE]

As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.

#immunology
#science
#tumor
#immunotherapy

https://t.co/Jlja2ejxDS

[Austin Newsam @AustinNewsam]

@tangming2005 Great breakdown and refresher! Haven’t thought about the role of preprocessing on PCA output. Regardless, does it functionally matter for downstream analyses? PCA is just a visualization tool won’t all downstream DE techniques (GSEA, GSVA) yield the same output?

[Marios Georgakis @MariosGeorgakis]

As an MD/PhD, I'm probably biased here, but I find these oversimplified generalizations hard to understand.

A quick look at any list of influential biomedical scientists (Nobel laureates, leaders across fields, big pharma CSOs, biotech founders) shows that MD/PhDs (or MDs deeply engaged in research) are prominently represented.

Many are also excellent clinicians, particularly in highly specialized or rare disease areas, where clinical insight is the often the only driver of scientific discovery.

So the claim that MD/PhDs "seldom advance either basic knowledge or clinical practice" doesn’t hold up. And the shift toward administrative or leadership roles later in one’s career isn’t unique to MD/PhDs.

Most MD/PhDs I know are among the hardest-working people in either medicine or science. They commit to 15-20 years of training and most often end up earning less than purely clinical peers.

[Austin Newsam @AustinNewsam]

@TaylorJ_MD This is great! Haha

[Austin Newsam @AustinNewsam]

Thankful to have had many students help this student gather data for my PhD. It’s clear this one knows I can’t zip it about my hobbies 😂

[Austin Newsam @AustinNewsam]

Interesting! Seems these two products are as much affected by their manufacturing process as they are their signaling domai .

Comparison of axicabtagene ciloleucel and tisagenlecleucel patient CAR-T cell products by single-cell RNA sequencing https://t.co/t7A3RA9sh8

[Austin Newsam @AustinNewsam]

@GreenLymphoLab @univ_paris_cite Wow thank you for this transparency. I’m a graduate student trying to publish my first, 1st author manuscript and highly look up to your work. Finally getting under review took some time and I’m wondering if this is how it always is. Your story gives me encouragement!

[Austin Newsam @AustinNewsam]

@MiriamMerad Has MSTP admissions been affected?

[Austin Newsam @AustinNewsam]

@TaylorJ_MD @univmiami @umiamimedicine @SylvesterCancer Woo congrats Anya!

[Austin Newsam @AustinNewsam]

@DanielJBrat @NUFeinbergMed @NorthwesternMed @NU_Pathology @LurieCancer Woahhhh congratulations Brat lab!! 💪🏼

[Austin Newsam @AustinNewsam]

@GongDennis The (gene) dose is the poison! V interesting though and will surely upset many in the field haha. Especially given the current attention to epitranscriptomics 🤔

[Austin Newsam @AustinNewsam]

@GongDennis This is amazing and surely will have our whole lab chatting! Question, were these specific lineages chosen for a reason? We are a lymphoma lab looking for the Lymphoid lineage but don’t see it on your figure. It’s a listed lineage on the Portal though so would love to know! TY

[Austin Newsam @AustinNewsam]

Labor of love 🔬🤝

JCI Insight - The financial impact of MD-PhD training compared with MD training for academic physicians https://t.co/01fIlgBc7C

[Austin Newsam @AustinNewsam]

Congrats and thanks for all your guidance, Francesco!! 🙌🏼 honored to have your mentorship

[Francesco Maura @FrancescoMaura4]

I am excited to announce that on Monday, I will begin my new journey at @MSKCancerCenter, joining @szusmani, @SohrabShah, @MSK_DeptOfMed, @CompOncMSK, and their incredible teams! Grateful for this unique opportunity and their support 🙏🙏! #mmsm #lysm