Avraham Ashkenazi

Investigating the cell biology of proteostasis and misfolded proteins in neurological disorders. Associate Prof. at Tel Aviv University.

[Avraham Ashkenazi @AvrahamLab]

Our paper published online in @Brain1878. We identify a cancer-associated #ubiquitin enzyme as a potential therapeutic target in #Huntington's disease. @TAUMedFaculty @of_sagol
https://t.co/5WG8z1oByE

[Nat Rev Neurology @NatRevNeurol]

New online! Extracellular matrix remodelling in neurological diseases https://t.co/c3pkAGERoc

[Eran Meshorer @meshorer1]

Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes?
Check out the new Shifman / Meshorer labs collaborative review in TiG @TrendsGenetics , lead by our amazing joint student, Elad Dvir👇👇👇
https://t.co/4pDuglXCoP

[Avraham Ashkenazi @AvrahamLab]

Elegant study on that fit the unconventional secretion mode of TMEM16F: Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles | Molecular Biology of the Cell https://t.co/jwviyC5dxc

[Nature Rev Neurosci @NatRevNeurosci]

Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders — a Review by Carissa L. Sirois, Jiyoun Lee, Audrey L. Chambers & Xinyu Zhao

https://t.co/hJBDJJBbUG

[Avraham Ashkenazi @AvrahamLab]

@NatRevMCB Very informative analysis for studying development and neurodevelopmental diseases involving the P-ANS

[tommaso patriarchi @tpatriarchi]

The most sensitive green and red #norepinephrine #sensors engineered to date are out in @naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @ERC_Research @snsf_ch @UZH_en @UZH_IPT https://t.co/uVrMGSds9p

[Avraham Ashkenazi @AvrahamLab]

Stochastic misfolding drives the emergence of distinct α-synuclein strains: Neuron https://t.co/FRxPu5yDlR

[Avraham Ashkenazi @AvrahamLab]

Elegant work. Congratulations to Julie and team. #Parkinson's disease #alpha-synuclein secretion

[Julie Jacquemyn @JacquemynJulie]

So excited to share our work on Glucosylceramide-induced ectosomes propagate pathogenic alpha-synuclein in Parkinson’s disease, now out @ Nature Cell Biology!

@NaturePortfolio

https://t.co/qxy1dOAOtc

[Avraham Ashkenazi @AvrahamLab]

Check our new work @NatRevMCB . It was fun working with Gali Prag on this piece. Stay tuned for more research on this exciting topic from our lab. Thanks 🙏 to referee and editor for the feedback @of_sagol @TelAvivUni

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! The emerging importance of UBA6 in ubiquitylation and proteostasis https://t.co/A5nYOHnenK

[Guillaume Laconde @Glaconde34]

PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington’s Disease | Journal of the American Chemical Society https://t.co/MRNM6PXRz4

[Avraham Ashkenazi @AvrahamLab]

Stay tuned for more research from our lab on this exciting topic!

[Avraham Ashkenazi @AvrahamLab]

Our article commentary is out in @NatRevMCB. 🎉 Together with Gali Prag, we discuss the emerging functions of the #ubiquitin enzyme UBA6 in health and disease. @of_sagol @taumed
https://t.co/uINKrk8DxW

[Avraham Ashkenazi @AvrahamLab]

Free access link to the paper:
https://t.co/lWTsOGf4RM

[Parkinson's Foundation @ParkinsonDotOrg]

We are excited to announce that the Parkinson’s Foundation and @ACSMNews, the world’s largest sports medicine and exercise science organization, have announced updated recommendations to provide safe and effective guidance on exercise for people with Parkinson’s disease.

The updated exercise recommendations were published following extensive review from subject matter experts, as well as members of the PD community who actively use the recommendations. Read more: https://t.co/pIJ1XHtsun

[Avraham Ashkenazi @AvrahamLab]

Congratulations Edward and team :beautiful work.

[Avezov lab @AvezovL]

New from our lab: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

It resolves in organelles e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

https://t.co/7hhAu5Z0qV

[Avraham Ashkenazi @AvrahamLab]

The consequences of this mechanism for prion-like aggregate spreading need to be explored. Congratulations! Nice.

[Nature Chemical Biology @nchembio]

A new paper reveals that adhesion GPCRs promote extracellular vesicle (EV) formation and EVs spread GPCRs into neighboring cells to activate G-protein signaling, providing a novel mechanism for cell-cell communication

https://t.co/QH1kcNDrIM

[Nat Rev Neurology @NatRevNeurol]

New online! Towards biomarker-based diagnosis of Parkinson disease https://t.co/6iYhwcAzuX

[Avraham Ashkenazi @AvrahamLab]

Important resource

[Brain @Brain1878]

Hupalo et al. present whole-genome sequences from >9000 human brain donors paired with neurological and psychiatric disease diagnoses. Created with multiple brain banks, the resource is now publicly available to aid research. https://t.co/sC7q5yI7SU

[ShorterLab @ShorterLab]

Protective ApoE variants support neuronal function by effluxing oxidized phospholipids: Neuron https://t.co/pwaIWYNVM1

[Avraham Ashkenazi @AvrahamLab]

@JCellBiol Congratulations Chen and Arad