🐝⭐️

I’m fit, I’m flirty and I’ve got double F’s

[Football Tweet ⚽ @Footballtweet]

🚨🇮🇹 Como have become one of the first clubs to BAN heading in their youth academy in a major move to protect young players' brain health. 🧠❌

▪️ U10: Heading banned completely. Kick-ins replace throw-ins and corners are played along the ground.
▪️ U11: Heading still banned, with limited technique work only introduced at the end of the season using lightweight balls.
▪️ U12: Maximum of one heading session per month, with no more than five headers.
▪️ U13: Heading allowed only in training once a week (max five headers), but remains banned in matches.

The initiative, led by Raphaël Varane, aims to reduce head impacts while children's brains are still developing and encourage greater technical ability with the ball at their feet. 👏🇫🇷

[Biggies Malls 2.0 @Biggies_MaIIs]

Trump when he handed out the runners up medal to Simeone

[َ @rmngifs]

red card in the world cup final

[Tottenham Hotspur @SpursOfficial]

Pedro with a massive goal for Spain in the World Cup semi-final! 👏

[Fenerbahçe SK @Fenerbahce]

Ve biz bugün, en yüksek sesle haykırıyoruz;
Kadınlara ve kız çocuklarına şiddet ve baskı uygulayanı, ortak olanı, tanıklık edip susanı affetmiyoruz!

[Bryan Johnson @bryan_johnson]

🚨Kate officially diagnosed with endometriosis

> done without surgery
> across three modalities: imaging, blood, and AI
> all non-invasive
> in 42 days

For context, average time to diagnosis is 6.6 years.

And, we found 2 other diagnoses at the same time.

Over the past 6 weeks, we’ve sprinted to confirm or deny Kate’s suspected endometriosis. Endo is notoriously challenging to diagnose.

It’s one of the most gnarly diseases and affects 15% of women.

Men, to get you on the same page, having endo is akin to an alien growing in your guts and balls, self replicating, and glueing everything together. Causing you constant pain and discomfort.

We got to work.

> got an MRI
> got a transvaginal ultrasound
> both results came back negative

At this point, Kate’s patient journey had followed the archetype precisely. Most women don’t get diagnosed for 7-10 years. For Kate, it’s been 7 years. And, like most women, her imaging came back clear even though now we know that she has endo.

This is why diagnosis has traditionally happened via surgery. There has been no other way than to open her up and look inside.

We wanted to avoid surgery so we went back to the drawing board. We searched the world over.

On our second go, we did:

> endo-specific ultrasound
> an endo blood test
> AI MRI
> saliva test

This was successful.

We were able to confirm her endo via ultrasound, blood test, and MRI. Confirmed simultaneously by three unique modalities, as far as we know, a world-first approach.

The extensive measurement allowed us to find additional things.

Her ultrasound showed:

> endometriosis
> PMOS (formerly PCOS) (needs confirmation)
> adenomyosis

30-40% of women have at least one of these conditions. That’s intimidating especially when the path to diagnosis is fraught with so many challenges.

Phase I was getting a diagnosis.

Phase II is curing endometriosis. We’ve already started working.

If you’re a female with suspected endo, here’s what you can do to accelerate your diagnosis.

—
1. Endo-Specific Ultrasound

You want an endo-specific ultrasound. As we saw with Kate, a standard pelvic/transvaginal ultrasound failed to identify her endo.

You want the ultrasound to be performed by a physician or sonographer specifically trained. They follow a special protocol to hunt for endometriosis by mapping the ovaries and uterus, and testing whether organs can slide freely, or are tethered by endometriosis lesions.

It’s best timed just after ovulation, when a small amount of peritoneal fluid aids visualization.

It can detect superficial endometriosis, lesions, and adenomyosis that general imaging misses.

We went to Dr. Kacey Hamilton at Cedar Sinai.

2. AI MRI / MatricesAI

Radiologists miss lesions in up to 60% of cases. We worked with @MatricesAI which leverages AI and a unique dataset to detect endometriosis lesions on pelvic MRI. This model is still new, its first pilot study with 200 participants began in April this year.

Here is how you can work with them:

They’re opening their diagnosis program at the Geneviève Institute to give early access to their AI model in a clinical trial.

They will take you through a state-of-the-art clinical intake questionnaire. Help you advocate for your symptoms with your gynecologist, based on your intake or connect you to a new center where their AI is being piloted and the clinical trial conducted.

3. Blood test / HerResolve

Kate had two small tubes of blood drawn for a test built by @Heranovalifesci.

The test measures seven biological markers (three microRNAs, three proteins, and one hormone) and uses an AI model to help detect endo.

It was highly accurate in its validation study at confirming endo and caught most cases that ultrasound and MRI had missed.

Their technology has been validated in a peer reviewed study (298 women, 11 sites across US/Europe/Hong Kong, published in the Journal of Minimally Invasive Gynecology): specificity 97.5%, sensitivity 80%, with strong diagnostic performance (94.4%), demonstrating it was highly effective at distinguishing women with endometriosis from those without the disease.

A positive result is a strong signal, since only 2.5% of women without endometriosis test positive, though final confirmation is still clinical. A negative is less conclusive, because the test misses about 20% of true cases.

The test identified 61.5% of histologically confirmed cases that transvaginal ultrasound and/or MRI missed.

#

We did one more saliva based test and will report back on that when results are returned.

[Alex 𝓕𝓪𝓷 @xAlexTHFC]

Absolutely mental that we haven’t announced a statue yet

What are we waiting for? @SpursOfficial

[Talking THFC @TalkingTHFC]

Seven handsome Korean fellas called RM, Jin, Suga, J-Hope, Jimin, V, and Jungkook.

[Mehdi Hasan @mehdirhasan]

Maybe the Europeans should have thought about all that back when they were colonizing Africa in the 19th century.

[🐝⭐️ @B_lal_]

@diol2n This looks like a scene out of South Park 😂

[george @StokeyyG2]

What a redemption story for Yaya Sithole.

👏🇿🇦

[i like food @messedupfoods]

Excellent use of free will

[N8 @Vararse_]

I’m crying this is like starlight before joining The Seven

[W @_common_w2]

There is a huge difference, when Higuain was getting abused, what did messi do?

Here is what Higuain himself said:

Gonzalo Higuain: "After the match, everyone in the locker room turned cold toward me and no one spoke.

Only Messi came over to me, hugged me, and said, 'No problem, this is football. We made it to the final and gave it our all.'

Later, the coach at the time told me not to come back to the national team, but once again Messi stepped in and talked to the coach. 'This isn't his fault. In football, we win and lose together. No one is perfect, he said. He changed the coach's decision.

That's how I got called back to the national team. If it weren't for Messi, I'd still be tormented by guilt to this day."

[Jovicism @ciszm]

It’s been 4 hours and this video still isn’t copyrighted are you thinking what I’m thinking?

[Will Hester @Will_Hesterr]

Spurs teasing a generational relegation before going around signing everyone’s best players

[hasanabi @hasanthehun]

yes and i am right.

[Ch1rag.ś @Ch1ragjpg]

@nautfcb U’ll only pass it to me won’t u bruno ?