Monika Bambouskova

Assistant Professor of Medicine @WUSTLmed @WashUMedEndo, alumni @imgprague. Lab focused on #immunometabolism, #signaling, inflammatory disorders.

[Monika Bambouskova @BambouskovaLab]

@gonzalo_lab Congratulations, Susana!

[Clair Crewe @CreweLab]

The first paper from the Crewe lab is online today. We found that macrophage-meditated clearance of EVs is a major determinate of circulating adipocyte EV levels. This clearance is disrupted in obesity. A huge effort by Snigdha Tiash!

https://t.co/Bl3hgB8Ep2

[Monika Bambouskova @BambouskovaLab]

Big congrats to @MargueriteMrad for winning the Outstanding Poster Award in basic science at Diabetes Day Symposium at @WashUMedEndo for presenting her work on immune-progenitor crosstalk in adipose tissue!

[Jeffrey Millman @JeffreyRMillman]

[please retweet] I’m #hiring! The Millman Lab is looking for a postdoctoral researcher to lead an exciting new project focused on vascularized #stemcell-derived islets for #diabetes disease modeling and cell replacement therapy. Email me your CV and cover letter.

[Alexey Sergushichev @assaron]

I'm happy to present our new web-tool CORESH https://t.co/r1bswFuZXo for searching public gene expression datasets using gene signature as a query, developed by @vd_sukhov, which was just published in @NAR_open https://t.co/PdDMgQz56a 1/n

[Maxim Artyomov @maxim_artyomov]

latest from our lab:
ITACONATE MECHANISM SOLVED!!

Tom Paulenda @tompaulenda solved molecular mechanism of immunoregulatory action of itaconate in macrophages:
https://t.co/efeSAW4ZTA

Previously, our lab has discovered two major immunoregulatory phenotypes of itaconate in macrophages - enhancement of type I interferon signaling and inhibition of late inflammasome activation (Swain et al, 2020 and Bambouskova et al, 2021). Yet the mechanism of immunoregulation itaconate has been elusive even though we (and others) have previously shown its ability to inhibit Sdh and its mild electrophilic properties.

In the latest work, we believe we have finally cracked that puzzle!!
We show that both immunoregulatory phenotypes are driven by the ability of itaconate to modulate ROS through non-covalent inhibition of the peroxiredoxin 5, mitochondrial peroxide-detoxifying enzyme.
We describe major new phenotypes for the pro-interferon action of itaconate in vitro and in vivo and show that Prdx5 inhibiton is sufficient for immunoregulatory action of itaconate and does not require neither Sdh inhibition nor its mild
electrophilicity.

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[Monika Bambouskova @BambouskovaLab]

@FumihikoUrano Thank you, Fumi!

[Monika Bambouskova @BambouskovaLab]

Honored and excited to receive the 2025-2026 CTRFP Award! 🎉 Grateful for the support as we continue exploring links between metabolism and autoimmunity.

[ICTS @ WashU in STL @WUICTS]

Read the ICTS Digest! Get to know the 2025-2026 CTRFP Awardees, register for the 7th ICTS Symposium, read articles in Missouri Medicine online journal & more! @WashUMedicine @WashUDeptMed @WashUSurgery @MIRimaging @MizzouNursing @SLU_Official

Read more> https://t.co/gOmIEgRo2x

[Monika Bambouskova @BambouskovaLab]

@LarryDSpearsJr Thank you, Larry!

[Monika Bambouskova @BambouskovaLab]

Please check out this new work on the role of tetraspanin CD53 in lung inflammation! Big congrats to @ivana_hal and the team!!

[Timothy Gottschalk @TimGottschalk]

If you have a sec, check out our new paper by @Amy_Hsu_ with @HibbsLab (@MonashImmunol) and @ivana_hal (@imgprague) showing that CD53 drives cellular infiltration and inflammation in allergic airway asthma-like disease in @AllergyEaaci (it's a quick read). https://t.co/CLV7l8eKJu

[Sergej Djuranovic @DjuranovicLab]

Collaborative work of @slavicaPD, @Hashemyaser4, Jovanovic Lab and @DjuranovicLab - a new method to isolate ribosomes and translational material in minutes. We show multiple usage of our RAPPL method in biochemical and structural assays with ribosomes. Please be free to contact us for further instructions if needed. @IsraelF96135088 you'll like this one.
A rapid, facile, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies https://t.co/qqJA6y2ysU

[ChristinaCamell @CamellChristina]

Preprint from my lab. Congrats @inhwajang_

Ina shows that Gdf3-SMAD pathway regulates macrophage inflammatory phenotype in old mice.

[Monika Bambouskova @BambouskovaLab]

@gonzalo_lab @NPF Thanks Susana!!

[Monika Bambouskova @BambouskovaLab]

Thrilled and grateful to receive this year's Discovery Grant from @NPF! 🎉 Excited to explore how dysregulated metabolism contributes to psoriasis pathology. Looking forward to the discoveries ahead!

[Monika Bambouskova @BambouskovaLab]

@jiripergner @NPF Thanks Jirka!

[Monika Bambouskova @BambouskovaLab]

@czexpats @NPF Thank you!

[Monika Bambouskova @BambouskovaLab]

@LarryDSpearsJr @NPF Thank you Larry!

[Monika Bambouskova @BambouskovaLab]

@assaron @NPF Thanks, Alexey!!

[Monika Bambouskova @BambouskovaLab]

@LodhiLab @NPF Thank you, Irfan!

[Jon Brestoff @BrestoffLab]

Very excited to share our latest paper out today
@NatMetabolism showing that #mitochondria transfer and transplantation may reduce the morbidity and mortality of #LeighSyndrome, a fatal mitochondrial disease with no effective therapies. https://t.co/fe8TaiJs9n