Paulino B. Iglesias

Senior Scientist II @abbvie Biological Research | Former Postdoc @UTDPainLab | PhD @cinvestav | Views my own.

[José Ramón Fernández @joserra_espn]

Extraordinario trabajo de @Jose_YulianLA Previo al anuncio oficial de México para el Mundial 2026.

[Will Renthal @willrenthal]

Pleased to share our latest work by Lily He, Parth Bhatia, Shams Bhuiyan et al. combining human and mouse DRG multi-omics with in vivo AAV screening to identify enhancers that bias gene expression toward distinct classes of nociceptors. @NIH_NINDS & HEAL

https://t.co/cSjix4nU3f

[Samuel Hume @DrSamuelBHume]

Top 5 advances in medicine in May (🧵)

1. A record-breaking genetic therapy

This bespoke CRISPR therapy was tailored for one patient's mutation, breaking two records: the first personalised gene editing, and (possibly) the fastest a medicine's ever been produced

There's a small risk of off-target editing, a requirement for lifelong immunosuppression, and how this looks in the long-term isn't known

Despite the limitations, this approach could - in theory - be used to treat hundreds of rare genetic illnesses

https://t.co/aFE4UnByMa

[Journal of General Physiology @JGenPhysiol]

Sooyeon Jo et al from the Bean Lab @harvardbrainsci use the Nav1.8 inhibitors suzetrigine, A-887826, & LTGO-33 to show differences in the kinetics with which the compounds unbind from depolarized channels and rebind to resting state channels. https://t.co/pHkLyqcVzu
#IonChannels

[Neuron @NeuroCellPress]

Online now: Single-cell spatial transcriptomic atlas of the whole mouse brain https://t.co/BupXrCedgX

[Samuel Hume @DrSamuelBHume]

Top 10 selling drugs globally in 2024

1. Keytruda (Pembrolizumab) – PD1 inhibitor (for cancer)

2. Ozempic (Semaglutide) – GLP1 receptor agonist (for obesity/diabetes)

3. Dupixent (Dupilumab) – IL4/IL13 inhibitor (for atopic/eosinophilic conditions)

4. Biktarvy (Bictegravir/Emtricitabine/Tenofovir) – anti-HIV

5. Eliquis (Apixaban) – anticoagulant (for atrial fibrillation/DVT/PE)

6. Skyrizi (Risankizumab) – IL23 inhibitor (for psoriasis/IBD)

7. Darzalex (Daratumumab) – Anti-CD38 monoclonal antibody (for multiple myeloma)

8. Mounjaro (Tirzepatide) – GLP1/GIP receptor agonist (for obesity/diabetes)

9. Stelara (Ustekinumab) – IL12/IL23 inhibitor (for psoriasis/IBD)

10. Trikafta (Elexacaftor/Tezacaftor/Ivacaftor) – CFTR modulator (for cystic fibrosis)

[Exa. @ExaArq]

Un día como hoy, pero de 1902, nació Luis Barragán, el gran arquitecto y el único mexicano que ha ganado el Premio Pritzker.

Les contaré las tres etapas que tuvo a lo largo de su obra y cómo evolucionó su estilo con el paso de los años. Con fotos mías en su mayoría.
🧵 Va hilo:

[Cheng Huang @ChengHuangThu]

This is the best in vivo AP propagation movie we got so far. Recorded at 1k Hz from the axonal branches of a fly CNS neuron, using voltage indicator pAce.

[Jane 💫 🚩 @jane4561313]

É do Brasil 🇧🇷!
Curitiba ❤️

[JAMA Neurology @JAMANeuro]

Anti-CGRP monoclonal antibodies were not associated with higher CVD risks compared to onabotulinumtoxinA in #Medicare beneficiaries with migraine, a group who were predominantly older adults or disabled. https://t.co/9RO2B6ikIg

[Dr. Rajesh Khanna of the KhannaLabUF @KhannaLabUF]

With stellar postdoc @Kimgmz6 as co-first author.

Kim holds a prestigious K99/R00 from NINDS and is ready to launch an independent lab.
📢Hiring committees, don’t miss this rising star!

[The Long Investor @TheLongInvest]

Where did it go wrong for Harris?

Biden dropped out too late

She didn’t have a Primary

Picking Walz as VP

Supporting Israel back fired

Harris was good during the debate but brutal during interviews

Getting Jlo, CardiB, Beyoncé to talk all back fired and a PR disaster…Diddys guest list

Obama guilt tripping black voters

Biden effectively turning on Harris

Harris Flip flopping on policies

Promoting being woke

Mark Cubans comments

Not focusing enough on the swing states

Allowing children to change their sex under the age of 12

Her fake laugh when she was nervous

Avoiding questions with long unrelated answers.

Flipping between being black, Indian, Middle Class and Working Class.

Her early political life.

And cancelling all public speeches when she knew she lost….reinforcing all of the above.

It was the very definition of how a campaign should not be run.

It was a masterclass of calamity.

[Paulino B. Iglesias @BarraganIP]

Today is a good day to cite a Mexican poet, Carlos Pellicer, who always praised the beauty of the Mexican tropics: the Mexican people have two obsessions: we are interested in death and we are in love with flowers. #DayoftheDead #DiaDeLosMuertos

[Anita Devineni @BrainsExplained]

Annual posting of my SFN bingo card for those of you headed to #SfN24

[Sholto David @addictedtoigno1]

This is apparently a protein-protein interaction diagram... Published in 2024 by Elsevier's Journal of Agriculture and Food Research. https://t.co/3IOcCGe4F4

[Samuel Hume @DrSamuelBHume]

Biggest medical discoveries of the week (🧵)

1. The inflammation that can happen in severe COVID-19 can be prevented (in mice!) with an anti-fibrin antibody - named '5B8'

(https://t.co/sD3lsXdxs4)

[Kimberly Meerschaert @KimMeerschaert]

Very excited to see my postdoc work from @IsaacChiuLab is out in @ScienceMagazine! Big thanks to my Co-first author @YanghopeZhu, CBDM lab, and all of our other collaboraters @DapingYang88 @himanishbasu @r_kwmt @SLiberles

https://t.co/vw6Imv1U82

[Samuel Hume @DrSamuelBHume]

The 10 biggest medical research papers from this week (in my opinion!)

1. The mTOR inhibitor, Rapamycin, extends lifespan in healthy mice, as does the MEK inhibitor, Trametinib

Combining both together boosts mice lifespan by ∼30%

https://t.co/Oa7QsZ8vMg

🧵

[Sanju Sinha @Sanjusinha7]

Have you wondered how Yamanaka found the 4-gene combination to transform somatic cells to stem cells? The # of possibilities are greater than - 20,000^4.

I did this yesterday & read the original paper.

What a journey & pure joy it was! Here’s how he did it. ⌛️

[The Neuro @TheNeuro_MNI]

Happy birthday to renowned neuropsychologist Brenda Milner, who is celebrating her 106th birthday today! 🎈 🎁

While she may not count her age among her many achievements, in this video she did share a few thoughts (and a bit of folklore) about birthdays past and present.