Gianmarco Bellucci

a very short space of time through very short times of space -

Been better a poet, actually an MD diving into Neurology and Multiple Sclerosis research

[Marios Georgakis @MariosGeorgakis]

Clinical diagnoses of cognitive impairment and dementia often reflect a mixture of different neuropathologies.

A GWAS with N up to 12,509 now explores the genetic architecture of neuropathologic features related with cognitive decline including
👉Alzheimer's disease pathologies (e.g. amyloid, tau)
👉other neurodegenerative pathologies (e.g. Lewy bodies, TDP-43)
👉cerebrovascular disease (e.g. atherosclerosis, arteriologsclerosis, CAA)
👉vascular brain injury (e.g. lacunes, white matter lesions)

[Multiple Sclerosis News Today @MSNewsToday]

In a "landmark" decision, the U.S. Food and Drug Administration approved Ocrevus for treating children and teens with relapsing-remitting MS. https://t.co/ZUyPPHIlWv #MultipleSclerosis #MSTreatment #MSResearch #MSNews

[Sasha Gusev @SashaGusevPosts]

Echoing this experience. I think we are losing the battle against surreptitious AI use in peer review, but I'm begging people who do it to at least check that their AI is not demanding a million laborious analyses that are not actually critical to the conclusions.

[VJ Neurology @VJNeurology]

Didn't get a chance to attend #ACTRIMS2026?🤔

Listen to our podcast, which covers key advances, including trial updates, novel technologies & more!

👉https://t.co/XrWl1qh2hL👈

Featuring Amit Bar-Or (@PennNeurology), Le Hanh Hua (@ClevelandClinic), Jeffrey Cohen (@ClevelandClinic), @BellucciGim, Raphael Schneider (@UofT), Valentina Fossati, Dalia Rotstein (@UofT), and Gary Cutter.

#ACTRIMS #MSResearch #ACTRIMSForum

[Eric Topol @EricTopol]

Our A.I. times :-)

[Eric Topol @EricTopol]

What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music
@ScienceMagazine
https://t.co/e9EFbJyXQ5

[Eric Topol @EricTopol]

The harmful and biased medical advice from social medial influencers, highlighting lack of expertise, and financial conflicts. Many specific examples and recommendations provided @bmj_latest
https://t.co/zFjaqQvi9O

[ECTRIMS @ECTRIMS]

🚨 A milestone for #MS care: The 2024 updates of #McDonaldCriteria are now available in @TheLancetNeuro. Earlier, more accurate #diagnosis means better outcomes for people living with MS. Access paper & resources 👉 https://t.co/vQC4Dy4xVh
#IACCTMS #ECTRIMS #Neurology @mssociety

[Eric Topol @EricTopol]

2 weeks later, Co-Scientist with further proof of agent science capabilities in drug discovery
https://t.co/W3pnsVRhvH @GoogleDeepMind

[Gianmarco Bellucci @BellucciGim]

Great work by @renato_umeton at @DanaFarber

[NEJM AI @NEJM_AI]

Case Study: The Impact of Task Set-up in Algorithm Design: Regression versus Classification https://t.co/2ItDoArgtG

Case Study: GPT-4 in a Cancer Center — Institute-Wide Deployment Challenges and Lessons Learned https://t.co/KxIg6Y3zjN

[NEJM AI @NEJM_AI]

Case Study: The Impact of Task Set-up in Algorithm Design: Regression versus Classification https://t.co/2ItDoArgtG

Case Study: GPT-4 in a Cancer Center — Institute-Wide Deployment Challenges and Lessons Learned https://t.co/KxIg6Y3zjN

[Nat Rev Neurology @NatRevNeurol]

Peripheral blood immune signatures are associated with distinct disease trajectories in multiple sclerosis | Science Translational Medicine https://t.co/qJlvlqIzNE

[ECTRIMS @ECTRIMS]

🏆 Congrats to Sergio Baranzini of @UCSF for winning @Mssociety's Barancik Prize for Innovation in MS Research. 🎧 Don't miss our recent podcast with Sergio and @AdilHarroud of @mcgillu on their discovery of the first #genetic marker for #MS severity. ▶️ https://t.co/co3p7hnrKB

[Gianmarco Bellucci @BellucciGim]

@Brandon_Beaber Hirayama disease!

[Gianmarco Bellucci @BellucciGim]

Another piece in the mosaic of EBV causal role in #MultipleSclerosis

[Nat Rev Neurology @NatRevNeurol]

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis | Science Advances https://t.co/lM2fpDXfFc

[Sasha Gusev @SashaGusevPosts]

This thread on human disease architecture generated a lot of interesting discussion and I wanted to highlight some important concepts that we still DON'T know the answer to (mostly suggested by others):
https://t.co/PIaZYIgA1c

[Sasha Gusev @SashaGusevPosts]

A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]

[Nature Biotechnology @NatureBiotech]

The culture of science has gradually transitioned toward a more executive and results-oriented approach, contributing to a less creative environment for transformative science https://t.co/nvWUAWbnCO

[Neurology Journal @GreenJournal]

As this case illustrates, inborn errors of immunity can underlie isolated encephalitis and should be included in the differential diagnosis of these presentations. Learn more: https://t.co/FYS0PQK6p2 #NeurologyRF #NeuroTwitter

[Sketching Science @sketchscience]

DNA Enzymes explained with earphones 🧬🎧