📣 Announcing the 2021 recipient of the Novartis Early Career Award in Chemistry: Josep Cornellà of the Max-Planck-Institut für Kohlenforschung.
Learn about his work @cornellalab that focuses on sustainable catalytic approaches in organic synthesis: https://t.co/fzGuPXGGMQ
I’ve enjoyed watching this percolate: NIBR researchers make COFFEE (covalent functionalization followed by E3 electroporation) to chemically assess potential for neo-substrate degradation. Strong brew showing hijackability of receptors & adaptors for TPD. https://t.co/90pz7fAxT9
Online now! A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes https://t.co/r4vraZFMC6 #chembiol
Our new paper is out in @nchembio where we describe our journey from a #covalent fragment screen to an in vivo active Pin1 inhibitor. https://t.co/DKdvmjYJ6f
Below is a musical abstract guest-starring @UriAlonWeizmann and a tweetorial 1/n
📢 We’re pleased to announce the 2020 recipient of the Novartis Early Career Award in Chemistry: Prof. Hosea Nelson of @uclachem.
Learn more about his work @thenelsonlab that aims to address long-standing challenges in organic #chemistry: https://t.co/nWCzJk3mbX
Our work on identifying selective CRBN modulators through a focused combinatorial library, phenotypic screening, and chemical proteomics is available in @ChemicalBiology. Great to work with @GuangyanD, @kdonovan1008, @RPNowak, and team. https://t.co/oT8sljkFmM
Happy to share a preprint of our method to assess whether E3 ligase components can be redirected for targeted protein degradation: Covalent Functionalization Followed by E3 Electroporation (COFFEE)!
Excited to share our work on the development and characterization of BJP-06-005-3, a covalent Pin1 inhibitor. Thank you to @zmdoctor, @behnamnabet, @manz_theresa, and the rest of the team - it was a pleasure working with you all! @nchembio
A new paper from Nathanael Gray and @BenikaPinch developed a covalent peptide inhibitor for PIN1 that decreased PDAC growth. Readable link at https://t.co/1KwpR5lnoe. https://t.co/viInUWqnzm