Benika Pinch

Principal Scientist I at Novartis Institutes for BioMedical Research

[Novartis Science @NovartisScience]

📣 Announcing the 2021 recipient of the Novartis Early Career Award in Chemistry: Josep Cornellà of the Max-Planck-Institut für Kohlenforschung.

Learn about his work @cornellalab that focuses on sustainable catalytic approaches in organic synthesis: https://t.co/fzGuPXGGMQ

[Radek Nowak @RPNowak]

Exciting #TPDWebinar ahead - Thursday 12:00 EST! @BenikaPinch and Seth Carbonneau from @NovartisScience #NIBR will combine COFFEE and IMiD inducible degron tags! #CART #DegradoZoom #TargetedProteinDegradation

[Jay Bradner, M.D. @jaybradner]

I’ve enjoyed watching this percolate: NIBR researchers make COFFEE (covalent functionalization followed by E3 electroporation) to chemically assess potential for neo-substrate degradation. Strong brew showing hijackability of receptors & adaptors for TPD. https://t.co/90pz7fAxT9

[Benika Pinch @BenikaPinch]

@RPNowak Thanks @RPNowak, looking forward to it!

[Benika Pinch @BenikaPinch]

COFFEE (covalent functionalization followed by E3 electroporation!) is online @CellChemBiol - it was great working with this team!

[Cell Chemical Biology @CellChemBiol]

Online now! A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes https://t.co/r4vraZFMC6 #chembiol

[Benika Pinch @BenikaPinch]

@behnamnabet @ErikoKoide @RockefellerUniv Congrats @ErikoKoide!!

[Benika Pinch @BenikaPinch]

@behnamnabet Congratulations, Behnam!! So excited for you!

[Benika Pinch @BenikaPinch]

@HartungIngo @Undruggable @NovartisScience Thank you, @HartungIngo!

[Benika Pinch @BenikaPinch]

@CARM1Monoxide Thanks, Carmen!!

[Covalent Modifiers @CovalentMod]

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo https://t.co/Fk91ugphVw

[London Lab @london_lab]

Our new paper is out in @nchembio where we describe our journey from a #covalent fragment screen to an in vivo active Pin1 inhibitor. https://t.co/DKdvmjYJ6f
Below is a musical abstract guest-starring @UriAlonWeizmann and a tweetorial 1/n

[Novartis Science @NovartisScience]

📢 We’re pleased to announce the 2020 recipient of the Novartis Early Career Award in Chemistry: Prof. Hosea Nelson of @uclachem.

Learn more about his work @thenelsonlab that aims to address long-standing challenges in organic #chemistry: https://t.co/nWCzJk3mbX

[Chelsea Powell @_CEPowell]

Our work on identifying selective CRBN modulators through a focused combinatorial library, phenotypic screening, and chemical proteomics is available in @ChemicalBiology. Great to work with @GuangyanD, @kdonovan1008, @RPNowak, and team. https://t.co/oT8sljkFmM

[Benika Pinch @BenikaPinch]

@CARM1Monoxide Thank you, Carmen!!

[Benika Pinch @BenikaPinch]

@manz_theresa Thank you, Theresa!!

[Benika Pinch @BenikaPinch]

Happy to share a preprint of our method to assess whether E3 ligase components can be redirected for targeted protein degradation: Covalent Functionalization Followed by E3 Electroporation (COFFEE)!

[bioRxiv @biorxivpreprint]

A Strategy to Assess the Cellular Activity of E3 Ligases against Neo-Substrates using Electrophilic Probes https://t.co/qb11PVrlba #bioRxiv

[C&EN (Chemical & Engineering News) @cenmag]

Lynn McGregor is a #proteindegradation expert developing technologies to unlock the secrets of the proteome for drug discovery. @NovartisScience https://t.co/pifN9aMIKX #cenT12 #DrugDiscovery

[Benika Pinch @BenikaPinch]

Excited to share our work on the development and characterization of BJP-06-005-3, a covalent Pin1 inhibitor. Thank you to @zmdoctor, @behnamnabet, @manz_theresa, and the rest of the team - it was a pleasure working with you all! @nchembio

[Nature Chemical Biology @nchembio]

A new paper from Nathanael Gray and @BenikaPinch developed a covalent peptide inhibitor for PIN1 that decreased PDAC growth. Readable link at https://t.co/1KwpR5lnoe. https://t.co/viInUWqnzm