Benjamin Tuck

CNS Biologist | PhD @Hughes_Hall @Cambridge_uni | My views and opinions are my own and not that of Astex/Otsuka Pharmaceuticals

[Benjamin Tuck @Benjamintuck_]

Delighted to see my PhD paper published! Using a new assay I found a critical role for cholesterol in tau entry to the cytosol. Cholesterol removal = massive seeding. Cholesterol addition = completely blocked!

Thanks to all involved in @w_mcewan lab!

https://t.co/mHNj3R5YAt

[Benjamin Tuck @Benjamintuck_]

@AmyShergold Massive congratulations Dr Shergold!!!

[Benjamin Tuck @Benjamintuck_]

It was a pleasure to be involved in this study highlighting the importance of type-I interferons in tau pathology - check out @_sophiesanford's thread for a great summary! Congratulations to all involved!! 🎉

[Sophie Sanford @_sophiesanford]

Excited to share my PhD work from the McEwan Lab, published today!

We found that type-I interferons exacerbate tau pathology, potentially linking upstream inflammation with downstream protein aggregation 🧠🦠:

https://t.co/hTN31vdply

@w_mcewan @UKDRI

🧵below:

[Patrycja Kozik @patrycja_kozik]

Join us to work on dendritic cells, cross-presentation, and T cell priming @MRC_LMB - we have two postdoc positions available, deadline on Monday Sept 25th

#CellBiology + #Immunology = 🥳

#PostdocJobs #AcademicTwitter

[Benjamin Tuck @Benjamintuck_]

https://t.co/fAun0tzJUg

[Benjamin Tuck @Benjamintuck_]

It has been a pleasure to be part of this new super-res study published in @CellReports! Check it out to see some very cool tau microscopy🔬 Massive congratulations to all involved! 🎉🎉

[Taxiarchis Katsinelos @TKatsinelos]

I am super happy to share our new manuscript published in @CellReports ! This has been an amazing journey primarily driven by @eldimou and I am honoured that I helped the story to get here! (1/5)

[Benjamin Tuck @Benjamintuck_]

I am thrilled to have been able to contribute to this important study from the Kozik lab published in @ScienceMagazine today! Massive congratulations to all involved 🥳

[Patrycja Kozik @patrycja_kozik]

Our work on perforin-2, a pore-forming protein expressed by #DendriticCells to deliver antigens into the cytosol during #CrossPresentation is now out in
@ScienceMagazine
https://t.co/ZdFoAyFQR2…

Huge amount of work from Pablo, in collaboration with
@laub_marco & @Pati_Krawczyk

[Benjamin Tuck @Benjamintuck_]

@w_mcewan Congratulations Will - fantastic news!

[Benjamin Tuck @Benjamintuck_]

@immunonoah @w_mcewan @ScienceMagazine No worries @immunonoah, thank you! Hope the interviews went well!!

[Benjamin Tuck @Benjamintuck_]

Very excited to share @w_mcewan labs new paper in @ScienceMagazine! I am thankful to have played a part in this story! We showed that TRIM21 is a dedicated cytosolic receptor required to neutralise tau seeds in AD models. Huge congrats to all involved!

https://t.co/a1wkpPXD1P

[UK Dementia Research Institute @UKDRI]

Super interesting study, led by @w_mcewan (UK DRI at Cambridge) reveals new insight into the mechanisms underlying an experimental antibody therapy for Alzheimer's🧠

The findings could pave the way for safer and more effective immunotherapy drugs👏👉https://t.co/UbmHpO2sdQ

[Benjamin Tuck @Benjamintuck_]

Congratulations on this huge achievement
@MukadamAamir @w_mcewan @TKatsinelos @Annabel_E_Smith @_sophiesanford @SophieKeeling8
twitterless Lauren Miller, Lise Skov, Chris Green @UKDRI and all other contributors!

[Benjamin Tuck @Benjamintuck_]

Great to be included in this study over the last few years from PhD to Postdoc! Pablo Rodriguez, @laub_marco, @Pati_Krawczyk, @patrycja_kozik @w_mcewan among other collaborators!

[Benjamin Tuck @Benjamintuck_]

Delighted to be involved in this fantastic piece of work from the @patrycja_kozik lab! Pore-forming protein Perforin-2 (Mpeg1) promotes the endocytic escape of antigens in DCs, allowing for their cross-presentation (and Mpeg1 promotes tau escape too!)
https://t.co/vei0Xxtup6

[Benjamin Tuck @Benjamintuck_]

@MRC_LMB looking pretty (and chilly) this morning ❄️

[Benjamin Tuck @Benjamintuck_]

Congrats to all poster winners from the Postdoc Symposium last week, and big congrats to Kozik postdoc @BoqueteLorena !

[Benjamin Tuck @Benjamintuck_]

Very proud to have recently accepted a postdoctoral associate position at such a diverse and pioneering college! 😃

[Lucy Cavendish College @LucyCavColl]

#LucyCavendishCollege has made history by becoming the first #Cambridge College to admit over 90% from state schools, and the most diverse intake of students ever admitted by any #College at #CambridgeUniversity

https://t.co/coQdvGPnr9
@CambridgeIndy @TheGuardian @Cambridge_Uni

[Benjamin Tuck @Benjamintuck_]

It was fantastic to hear the story of the BioNTech SARS-CoV-2 mRNA Vaccine from its Co-founders Ugur Sahin and Özlem Türeci today as dual Milstein lectures at the @MRC_LMB! In 2019, production only allowed 10,000 doses of mRNA vax. Now 3 billion have been produced in a few years!