Bhandoola_Lab

As a lab, we're all in.

[Bhandoola_Lab @Bhandoola_Lab]

Arundhoti Das' review on ILC development was published, shortly after she started her own lab. Yi Ding and Christelle Harly are co-authors.
https://t.co/3N4EVLAdgr

[Bhandoola_Lab @Bhandoola_Lab]

https://t.co/DjDgCOG7Rr
NFIL3 resides at the apex - as far as I know, at least - of a transcription factor hierarchy that initiates innate lymphoid specification.

[Bhandoola_Lab @Bhandoola_Lab]

Much to add. Two long obsessions, finally published last year.
First, this one:
https://t.co/eWrjRszERh
Is thymic involution consequential for immune responses? If you could figure out how to prevent it, or reverse it, would it matter?

[Bhandoola_Lab @Bhandoola_Lab]

@HBorgesdaSilva Congratulations!

[Bhandoola_Lab @Bhandoola_Lab]

@DrAntonioPagan @CFI_UMN Congratulations, Antonio! What a pleasure to see your well-deserved success.

[Bhandoola_Lab @Bhandoola_Lab]

Our colleagues will of course decide whether the new NK classification proposed by @EricVivier1 is useful. What their decision, I do think a classification that makes sense of both mouse and NK subsets would be very useful to the field.

[Bhandoola_Lab @Bhandoola_Lab]

Our contribution was to show that mouse NK cells develop by 2 pathways, and that the transcriptional signatures that defined these 2 mouse NK subsets also distinguished human NK subsets defined by CD56.

[Bhandoola_Lab @Bhandoola_Lab]

Glad to have contributed to the work by
Rebuffet, @EricVivier1 and colleagues, reposted below.

[Nature Immunology @NatImmunol]

Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here: https://t.co/fTaQp3LNxC
https://t.co/yZrLSXRhhl

[Bhandoola_Lab @Bhandoola_Lab]

And here are the links to the two new papers in Nature Immunology.
From us and our collaborators @SimonGrassmann, @SunLab_Official, @BelkaidLab

https://t.co/ZaxtS0G5Sa

From the lab of Bendelac and McDonald:
https://t.co/ZYbuf9mfrJ

[Bhandoola_Lab @Bhandoola_Lab]

And here is the thoughtful N&V from Emma Patey &
@bjorkstrom_lab

https://t.co/GCseoLjcc4

[Bhandoola_Lab @Bhandoola_Lab]

Such a bittersweet surprise to be back to back in Nature Immunology with Albert. To my thinking, our two papers are very complementary.

[Bhandoola_Lab @Bhandoola_Lab]

The original papers are here, one from our lab, one from the lab of Albert Bendelac.
https://t.co/WWLyIlhDsC
https://t.co/6nFFQXtOha

[ImmuNoah'sArk @immunonoah]

Great summary from Emma Patey & @bjorkstrom_lab about the 2 recent papers studying NK cell developmental origins from the late Bendelac's lab & the Bhandoola's lab: https://t.co/GvLLvBDMrm

ILCs with more nuance!

Orginal studies: https://t.co/MFfl2XBFlG
https://t.co/DBA6g0l0RJ

[Nature Immunology @NatImmunol]

Bhandoola and colleagues describe the existence of two developmental pathways that give rise to functionally distinct NK cell subsets. Read it here: https://t.co/seVYU7nx0t
https://t.co/HHZOT9yRMF

[Bhandoola_Lab @Bhandoola_Lab]

The CCR media team has a succinct outline of this latest work from our lab:
https://t.co/pp6CPWHjdt

[Immunity @ImmunityCP]

Online now: Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut https://t.co/F8oa0MLzw1

[Bhandoola_Lab @Bhandoola_Lab]

https://t.co/rruCpomL41

Other recent work from our lab. Stay tuned for more.

[Bhandoola_Lab @Bhandoola_Lab]

And here's the link to the paper itself, below.
https://t.co/aIehlInOeC

[Bhandoola_Lab @Bhandoola_Lab]

Bone marrow plasma cells require P2RX4 to
sense extracellular ATP
https://t.co/mZIT0bi4fB
The link is to a web-readable version of our lab's first paper on plasma cells. From a very fun collaboration between our lab at the National Cancer Institute and David Allman's lab at Penn.