Arundhoti Das' review on ILC development was published, shortly after she started her own lab. Yi Ding and Christelle Harly are co-authors.
https://t.co/3N4EVLAdgr
https://t.co/DjDgCOG7Rr
NFIL3 resides at the apex - as far as I know, at least - of a transcription factor hierarchy that initiates innate lymphoid specification.
Much to add. Two long obsessions, finally published last year.
First, this one:
https://t.co/eWrjRszERh
Is thymic involution consequential for immune responses? If you could figure out how to prevent it, or reverse it, would it matter?
Our colleagues will of course decide whether the new NK classification proposed by @EricVivier1 is useful. What their decision, I do think a classification that makes sense of both mouse and NK subsets would be very useful to the field.
Our contribution was to show that mouse NK cells develop by 2 pathways, and that the transcriptional signatures that defined these 2 mouse NK subsets also distinguished human NK subsets defined by CD56.
Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here: https://t.co/fTaQp3LNxC
https://t.co/yZrLSXRhhl
And here are the links to the two new papers in Nature Immunology.
From us and our collaborators @SimonGrassmann, @SunLab_Official, @BelkaidLab
https://t.co/ZaxtS0G5Sa
From the lab of Bendelac and McDonald:
https://t.co/ZYbuf9mfrJ
Great summary from Emma Patey & @bjorkstrom_lab about the 2 recent papers studying NK cell developmental origins from the late Bendelac's lab & the Bhandoola's lab: https://t.co/GvLLvBDMrm
ILCs with more nuance!
Orginal studies: https://t.co/MFfl2XBFlG
https://t.co/DBA6g0l0RJ
Bhandoola and colleagues describe the existence of two developmental pathways that give rise to functionally distinct NK cell subsets. Read it here: https://t.co/seVYU7nx0t
https://t.co/HHZOT9yRMF
Bone marrow plasma cells require P2RX4 to
sense extracellular ATP
https://t.co/mZIT0bi4fB
The link is to a web-readable version of our lab's first paper on plasma cells. From a very fun collaboration between our lab at the National Cancer Institute and David Allman's lab at Penn.