BioPrime

10,000x faster drug discovery
$5 vs $50,000+ for molecular docking
Production platform running 24/7
Melanoma • Diabetes • HIV
🧬

[Bryan Daugherty, CCI, CBI, SME @BWDaugherty]

Just completed a drug discovery screening on @BioPrimeAI! Target: CDK4/6 - Breast Cancer | Best binding energy: -13.46 kcal/mol | Advancing science with decentralized compute. https://t.co/2iMXiZYY3Q

[CatGod @CatGodSandHive]

@BWDaugherty @BioPrimeAI **Seeing such strong binding energy begets hope for impactful treatments.** w/

[BioPrime @BioPrimeAI]

We are proud to announce TopoGrammar, a platform designed to illuminate the "dark matter" of the genome. While traditional pipelines focus on dosage, #TopoGrammar focuses on topology.

[Bryan Daugherty, CCI, CBI, SME @BWDaugherty]

Introducing TopoGrammar: Cracking the "VUS" Code with 3D Genomics & Blockchain

68% of identified ##genomic variants are currently classified as "Variants of Uncertain Significance" (#VUS). For patients, this means a #diagnostic dead end.

The Problem: Conventional sequencing misses "balanced" structural variants, inversions and translocations that don't change gene dosage but do wreck the genome's 3D regulatory architecture.

The Solution: #TopoGrammar treats chromatin organization as a structured language. By modeling enhancers and promoters as "grammatical sentences," we identify disruptions that others miss.

The Tech:🧬 PINNs: Physics-informed neural networks for high-fidelity 3D reconstruction. 🎯

- CTCF-Gating: 91% boundary detection accuracy (outperforming HiCCUPS). ⛓️ #Blockchain

- Attestation: Every result is hashed to the #BSV blockchain for immutable, @US_FDA-compliant verification without exposing PHI.

The Results:• 68% VUS reclassification rate. • 93% pathogenic accuracy. • Seamless integration with @BioPrimeAI v4.0 for genome-to-drug workflows.

Stop guessing on VUS. Start decoding the #3Dgenome.

🔗 Try the Live Demo: https://t.co/EEUuiIdHWL

@SmartLedgerTech @bioprimeai @Sdot2121 @Codenlighten1 @jalexanderm @grok
#Genomics #PrecisionMedicine #AI #Biotech

[BioPrime @BioPrimeAI]

@RIPVaulted @jalexanderm Thank you! 💗 This is citizen science in action. Welcome to the future of DeSCI

[Bryan Daugherty, CCI, CBI, SME @BWDaugherty]

https://t.co/iP24qCySZJ

[BioPrime @BioPrimeAI]

@BWDaugherty @jalexanderm We BELIEVE @jalexanderm @SmartLedgerTech
Thank you!

[BioPrime @BioPrimeAI]

♥️

[Bryan Daugherty, CCI, CBI, SME @BWDaugherty]

Thank you @jalexanderm!

[BioPrime @BioPrimeAI]

@Codenlighten1 @SmartLedgerTech IYKYK

[BioPrime @BioPrimeAI]

BioPrime's sponsor community is making history. @jalexanderm leading breast #cancer #research. @SmartLedgerTech, @OriginNeuralAI, @BWDaugherty, @Codenlighten1 & @Sdot2121 backing 10 disease targets from #Alzheimer's to #tuberculosis. 6.3M compounds screened. DeSCI ♥️

[BioPrime @BioPrimeAI]

BioPrime live stats: 6.3M compounds screened, 18 jobs completed, 28 users, 62.9s avg completion time. Every job coordinated on BSV—micropayments, result verification, data provenance, fractionalization. This is what production infrastructure looks like in drug discovery. 🧬⛓️

[BioPrime @BioPrimeAI]

Drug discovery demands immutable #data provenance.

BioPrime uses #BSV (@SmartLedgerTech) to timestamp every docking result, ensuring #research integrity from compound screening to publication.

When lives depend on your data, you don't compromise on #blockchain capacity.

[BioPrime @BioPrimeAI]

Yes 🙌

[ripvaulted @RIPVaulted]

This is amazing ❤️ and needs more awareness! From women across the globe, let me say, thank you @jalexanderm and @BioPrimeAI!

What an amazing opportunity!

[BioPrime @BioPrimeAI]

"Finding cures shouldn't be locked behind pharma
boardrooms."

@jalexandermartin just became our sole Breast
Cancer Research sponsor - and he's giving $5 to
every new citizen scientist who joins.

1 million compounds. Free.

🎀 https://t.co/rPFTDZg1W2

[vikram @vikramh]

@BWDaugherty @BioPrimeAI Fascinating stuff, sir 👍

[BioPrime @BioPrimeAI]

⚡️ Enhancements:
• Grid-based sampling
• Adaptive parameters
• Multi-start optimization

Goal: Match Vina's 70% success rate on blockchain rails.

This is the future of #DeSci 🧬🔗

#Biotech #DrugDiscovery #Web3

[BioPrime @BioPrimeAI]

🔬 BioPrime Engine Deep Dive

We're live-benchmarking our improved docking algorithms:

📈 Results so far:
• 16% better RMSD (closer to crystal structure)
• Testing: HIV protease, kinases, GPCRs
• 200 poses × 100 GD steps × 30 ILS iterations

[BioPrime @BioPrimeAI]

@GlucoseNot @BWDaugherty Metabolic targeting is why BioPrime screens multiple cancer pathways.

Active campaigns:
• Melanoma (BRAF V600E)
• Breast cancer (CDK4/6)
• HIV-1 Protease

Targeting metabolism requires compounds that work. Molecular docking accelerates discovery.

[BioPrime @BioPrimeAI]

@cryptotweek1 Exactly right. Every BioPrime docking result → BSV blockchain → immutable proof.

No lab notebooks. No trusted intermediaries. Just cryptographic hashes + timestamps.

Blockchain as public notary for computational science.

[BioPrime @BioPrimeAI]

Same optimization engine powering BioPrime's 10,000x drug discovery speedup.

OriginNode proves it in blockchain.
BioPrime proves it in molecular docking.

Production-validated.

42.9% improvement under adversarial conditions speaks louder than any whitepaper. 🧬

[Bryan Daugherty, CCI, CBI, SME @BWDaugherty]

Blockchain node that gets BETTER under attack?

Just verified OriginNode:
- +42.9% improvement under stress
- 3.85s to complete
- Immutable BSV proof

https://t.co/QiyJSyEG8p

The Daugherty Engine is real. #BSV

[BioPrime @BioPrimeAI]

@BWDaugherty 🎁 Reminder: Every signup gets $5 free credit That's 1 million compounds screened. For free. No payment required. Students, small labs, researchers anywhere—just sign up and run your campaign.

Democratizing drug discovery, one free million at a time.

https://t.co/SHpVT4RkPO