BiocEM Cambridge

Cryo Electron Microscopy facility at Department of Biochemistry, University of Cambridge. This is a shared account.

[Structure @Structure_CP]

Team headed by Amanda Chaplin reports the cryo-EM structure of a DNA-PK trimer, which is a key enzyme for DNA double-strand break repair and they discuss the potential for higher order DNA-PK assemblies @AmandaChaplin10 @BiocEMcam @uniofleicester

https://t.co/ECMba3zJ6W

[Mairi Kilkenny @mairikilkenny]

Yay, our new pre-print - many congrats to Zhan Yin @PellegriniLab! 👏👏🥳
CryoEM insights into RNA primer synthesis by the human primosome https://t.co/sP7ykqzfUK

[The Lister Institute of Preventive Medicine @ListerInstitute]

A year after she won the Lister Prize, we catch up with @AmandaChaplin10 to learn more about her work on DNA breakage and repair, and discover how the award will help her pursue her research goals 🔬

Read more here: https://t.co/2r7tB5tl9B

[Pellegrini Lab @PellegriniLab]

Research Associate (Fixed Term) @Cambridge_Uni https://t.co/VoXaKcLJ3K
Great job opportunity at @CamBiochem in the @PellegriniLab . If you're interested in molecular mechanisms of DNA repair and replication, please apply and join us. We're looking forward to your application! 🙂

[BiocEM Cambridge @BiocEMcam]

In this short article we provide evidence of these higher order assemblies, and discuss the potential formation of filament like assemblies, whilst giving our opinions of potential biological roles of such assemblies.

[BiocEM Cambridge @BiocEMcam]

Happy to share the latest work by @AmandaChaplin10 in collaboration with Kathy Meek, @CharbonnierJea7, ourselves @CamBiochem and others
https://t.co/LdUZqL5jDj

[BiocEM Cambridge @BiocEMcam]

@AmandaChaplin10 @CharbonnierJea7 @CamBiochem Within this dataset we noticed the presence of a small population of particles representing higher order oligomers of DNA-PK. These are able to form via the combination of the two previously reported dimer forms.

[BiocEM Cambridge @BiocEMcam]

@AmandaChaplin10 @CamBiochem @LeicStructBio @CharbonnierJea7 Also check out the related research article from @YuanHe_NWU https://t.co/3pDERTQyKu

[BiocEM Cambridge @BiocEMcam]

The latest work from @AmandaChaplin10, work initiated at @CamBiochem and continued at @LeicStructBio https://t.co/PWRXMgUpWr

[BiocEM Cambridge @BiocEMcam]

@AmandaChaplin10 @CamBiochem @LeicStructBio This was part of a highly collaborative project including ourselves at @BiocEMcam, @CharbonnierJea7 , Kathy Meek, Patrick Calsou and others

[BiocEM Cambridge @BiocEMcam]

Congratulations Amanda - keep up the stunning work!

[The Lister Institute of Preventive Medicine @ListerInstitute]

Lovely to see this @BBCNews piece about @AmandaChaplin10 - one of our newest cohort of #ListerFellows! https://t.co/LjpsTG4HwO

[LISCB @LeicStructBio]

Midlands Cryo-EM Facility @uniofleicester has a permanent post for an Experimental Officer to assist/ train users on everything Cryo-EM incl sample preparation, data collection &processing. We have a Titan Krios G3-Bioquantum-K3, screening microscope etc https://t.co/BnWiQAiuRk

[Lori Passmore @lapassmore]

New work from @_M_Carminati shows that dephosphorylation of RNA polymerase II by CPF (the 3' end processing machinery) promotes Pol II dimerisation. @mcemremnv @MRC_LMB @ERC_Research

[Paul Miller @PMillerLab]

The Miller lab @UnivCamPharm is looking for an enthusiastic postdoc to study antibody modulation of ion channels!

A previous relevant publication from our group is https://t.co/XTBPsCIU6J

Job details 👉 https://t.co/lfeg6Em2hh

DEADLINE 15th JULY

[Paul Miller @PMillerLab]

The Miller lab is delighted to announce its first publication! Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA receptors. https://t.co/XTBPsCIU6J. @Nature @vikrambabu @UnivCamPharm @BiocEMcam and Smart Lab @uclnpp

[Vikram Kasaragod @vikrambabu]

Happy to share our paper out in @Nature, which provides insights into activation and inhibition of a subset of extrasynaptic GABA(A) receptors. @PMillerLab @UnivCamPharm @BiocEMcam and Smart Lab @uclnpp https://t.co/QD4JfB1wl9

[Shikang Liang @S_Liang_]

Excited to share our latest cryo-EM work @Nature of Blundell group @CamBiochem @BiocEMcam on ligand regulation of DNA-PKcs, a key kinase in DNA damage response and repair. Inhibitor mode of action now better understood and more to explore! Check it out:
https://t.co/UoCuZZIgkE