💯🧬 Jake 🧬💯

👽 🪦 🧟 👽

💯 Club 💯

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

Need to repopulate some stuff.

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@DonP2188 Shoulders popping!

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@DigitalFringed1

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

Chicken, potatoes, cottage cheese!

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@DigitalFringed1 Oh don’t worry, they will report that too lol.

I will have another and another and another.

You will never escape the cottage cheese

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

100% agree with Chef Mike.

The anti-creatine movement is full of complete whack jobs..

[💯Mike Appy aka Crema💯 @DigitalFringed1]

Yes

I'm back on creatine

There's just too many positive things to not be taking it

Fuck it

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@DonP2188 Crushing it! 🔥

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

https://t.co/DgkzAISBdG

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

Looking like a Friday thing? 👀

JBSNF-000088 is the one you actually want if the whole point is an oral NNMT inhibitor in a mouse lab-rat setup.

Funny, as I knew of this as a different name, but for the sake of this lol, happy to see it added as I had to rush to gather a bit more than I understood about it after I was given the heads up its hitting Elite!

Look at this as potentially being a much better version..... Though I have no lab-ratted it myself yet, and wont be for some time due to current plans.

Also, everything mentioned is strictly intended for research, personal research, nothing more.

5-Amino-1MQ gets the forum hype (which initially I was a fan of, and still kinda like the oral at high dose in a cut), but the published mouse work that made it famous was almost all subcutaneous (which is now hit or miss more than people think). When they finally measured oral in mice, it fell apart until doing was above cost worth for most

Both hit the same enzyme. NNMT methylates nicotinamide into 1-MNA and burns SAM doing it. Block it and you drop MNA, spare SAM, and in the fat-mouse papers you see less weight gain, smaller fat pads, better glucose tolerance, and lower triglycerides. That’s the whole “metabolic recomp” story people chase.

Where they split is the route.

JBSNF was built as a small nicotinamide analog and run oral from the start. In mice it hits about 40% oral bioavailability. 10 mg/kg oral gavage gives a Cmax around 3,500 ng/mL and peaks in half an hour. The diet-induced obese mouse paper dosed it 50 mg/kg twice a day by mouth for 4 weeks and got the body-weight drop, lower fed glucose, normalized oral glucose tolerance, less liver and plasma fat, and lower MNA in visceral fat.

Clean enough selectivity panel, negative Ames, soluble, and it actually absorbs.

5-Amino-1MQ is a charged quinolinium. Membrane-permeable enough for cells and for a needle, which is why the original Neelakantan obesity paper used 20 mg/kg subcutaneous three times a day and saw the fat-mass cut. Oral is a different animal. The 2024 mouse PK paper put oral bioavailability at about 3.5-10%. After 30 mg/kg by mouth the Cmax was only 14.5 ng/mL and it crawled in over 4 hours. High clearance in mouse hepatocytes, bad first-pass, poor enteric absorption. Rat data looks better (around 38% oral, longer half-life), but the efficacy literature everyone quotes is mouse, and in the mouse the oral number is garbage. So if you “just take it oral like the capsules,” you are mostly guessing against a species where the published oral exposure is tiny. Me personally, I still am/was a fan above 150mg, with proper deficit, AM initially. Even oral. I’m in minority there.

The catch on JBSNF is the half-life. About .4-.5 hours in mice, IV or oral. It gets in fast and leaves fast. That’s why the working protocol was twice daily, not once. 5-Amino hangs around longer when it actually gets into plasma (rat oral half-life around 7 hours), but that only matters if it absorbs. In the mouse oral setting it mostly doesn’t.

So the bro logic is simple. If the experiment is “oral NNMT inhibitor, mouse, look at weight and glucose,” JBSNF is the compound that was actually shown to do that by mouth, with real bioavailability and a published oral efficacy regimen. 5-Amino is the compound that works when you inject it and largely disappears when you feed it to a mouse. Short half-life means you dose JBSNF more often, but its likely 10x more impactful for the purpose would intend it for.

All in all, I'm seriously happy to see more orals popping up because that is the direction the market needs to go in the areas it can.

@EliteresearchUS

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@trinity2pointO I mean… was just waiting…..
Incoming….

[THE REAL 💯D👀KS💯 @trinity2pointO]

I just put 20% off plus an extra 10% with your favorite affiliate code for next 24 hours.

Also, I did the same for DMAA (1,3).

[Elite Research USA @EliteresearchUS]

PE-22-28 is now 20% off!

This is a synthetic spadin analog used for mood-regulation research. It works by inhibiting TREK-1 channels in the hippocampus. This mechanism provides anti-depressant effects by...

1. Preventing the outward flow of potassium ions in neurons, leading to cellular depolarization

2. Triggering rapid neuroplasticity by stimulating BDNF which has been shown over and over again to be therapeutic in all depression models. It is also shown to quickly increase neurogenesis and synaptogenesis.

Unlike SSRIs, which block the reuptake of serotonin, this allows the serotonin neurons to naturally just fire a little bit harder.

Anecdotally, everyone seems to have the same research results.

- Rapid mood enhancement
- Increased feelings of excitement for average tasks
- Anhedonia relief
- Better stress adaptation
- Enhanced motivation
- Less rumination on problems and the past
- Better equipped to handle depressive events

More BDNF is shown to be neuroprotective and be a main pathway for memory and focus, this is why so many researchers report nootropic effects with this not just mood enhancement.

**Effects are achieved rapidly**
**Research use only**

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@KleosOperator 🔥

[Richard @PGC1a_RB]

Since I got a few questions about my bro-split, will answer for clarity:

8-days: lifting every other day, applying rest-pause (DC sets, Dogcrapp principles; straight sets, and weighted stretching of the muscle groups trained that day, after the lift session)

Lift day 1: Chest, back, delts

HIIT + LISS or just LISS or rest and only steps/walking, accounting for fatigue (same logic applies for other days in-between lift days)

Lift day 2: Arms, delts, hamstring

HIIT + LISS or just LISS (just LISS if HIIT done 2 days ago)

Lift day 3: Back, chest, delts

HIIT + LISS or just LISS/walking

Lift day 4: Arms, Legs

HIIT + LISS or just LISS/walking

HIIT is never done 2x in a 4-day period

In an 8-day period
Chest and back hit 2 days directly
Delts hit 2 days directly
Arms hit 4 days, 2x directly, 2x indirectly
Hamstrings hit 2 days
Quads hit 1 day

'Upper body focused bro split'

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

Dihexa run begins again…

It’s been too long.

Of course…

It’s paired with Tesofensine.

You all with your little moda, bro, etc.

Long term benefits (imo for me) with “respectable” risk profile.

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

RT @tonymission: Throws the whole concept of "third-party tested" out the window. Pretty wild that people are doing this and don't see the…

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

That takeover looked like a fucking great time.

We visited the step daughter during the timeframe but anything like that again here I’ll make sure it’s not missed.

Would have loved to get some lifts in with you guys.

Pull the mask away from “Biohacker” persona 😂

Love a good time

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@DigitalFringed1 The “grift” lives on brother

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

Good people, and love Apples energy, even though he pops up in the tele with some of the most random bizarre statements of all time 😂

My dude @Applesa18888542

Rogue ninja like shit area in the grey market, and I’m here for it lol

[POCKETS @joeypocketino]

Yup. You got this kid. ✅

[💯🧬 Jake 🧬💯 @Biohacker_Jake]

@aus877 Jammin!! Lfg