Mirko von Elstermann

PhD,#physiology; also #librarian/#philosopher/#editor—keen on #basicresearch/#pathogenesis [#cancer]/#neurobiology/#metabolism/#systemsbio/#omics/#genomeediting

[Mirko von Elstermann @BiomedRevon]

With a special emphasis on #memoryformation. "#Histone modifications, #DNAmethylation & #nucleosome remodelling (Fig. 1 [below]) are 3 of the best-studied mechanisms that directly modulate #chromatin structure to regulate the expression of genes related to #learning and memory."

[Gene Regulation @generegulation]

How the epigenome integrates information and reshapes the synapse [review] https://t.co/kcNKx37PnS

[Mirko von Elstermann @BiomedRevon]

Insufficient #sleep (esp. quality) increases #pain perception—in 2 ways:(1) It ↑ pain reactivity of the #somatosensorycortex; (2) it ↓ reactivity of areas that integrate body signals for #selfregulation, leading to an over-estimation of the pain stimulus.https://t.co/BL2bZhRIuL

[Mirko von Elstermann @BiomedRevon]

#ALS caused by *non-linear* combinations of variants. "[The #GWAS] approach has been found to be unable to find the non-additive combinations that are associated with #phenotypes...We view our work as a first step towards #biology-informed #deeplearning for association studies."

[bioRxiv @biorxivpreprint]

Using the structure of genome data in the design of deep neural networks for predicting amyotrophic lateral sclerosis from genotype https://t.co/yW1uFQk2h5 #bioRxiv

[Mirko von Elstermann @BiomedRevon]

How alternative #splicing drives #cancerogenesis: #Splicingfactor SRSF1,
overexpressed in many #cancers, causes >1300 AS events in #gliomas (esp. skipped exons).Resulting full-length membrane MYO1B accelerates
#glioblastoma via PDK/AKT+PAK/LIM #signaling.https://t.co/7kBhNK2mS7

[Mirko von Elstermann @BiomedRevon]

How (nm) #structuralproteins direct (μm) events involving #cellmembrane shape:#Septin octamers, driving, eg, cytokinesis, sense shape thru curvature-dependent association rates. Presence+arrangement of septins' amphipathic helixes govern molecular sensing.https://t.co/HuE2qG1woO

[Mirko von Elstermann @BiomedRevon]

Nature Behaviour title+text:"Extreme opponents of #geneticallymodifiedfoods know the least but think they know the most." "Those with the strongest anti-consensus views are the most in need of #education." Interestingly, this isn't valid re. #climatechange.https://t.co/4Dx2s5RD5K

[Lee Phillips @lpfeed]

Foes of genetically modified foods know less than they think, study finds: “The surveys asked respondents how well they thought they understood genetically modified foods, then tested how much they actually knew with a battery of true-false questions on… https://t.co/ZoSniXJm6s

[Mirko von Elstermann @BiomedRevon]

#Celltype-independent #transcriptionfactor–DNA binding patterns? Serum-response TF shows general #genepromoter occupancy oscillations: short–intermediate–long-binding molecule groups. Central #cellsignaling axes(#MAPK, Rho/#actin)impact specific bdg phases.https://t.co/lBhZ5xoH9Q

[Mirko von Elstermann @BiomedRevon]

By def.—or in theory, as it's valid for a fraction of articles only—high-IF journal articles are cited more than low-IF journal art. Thus, a 26% increase of low-IF journal articles could be considered of similar worth as the 74% of high-IF ones. So, clear writing always pays off!

[Mirko von Elstermann @BiomedRevon]

Write with the reader in mind to increase impact & citations. Methinks clarity is 1st, e.g., using connectors to improve text flow, or reducing (idiosyncratic) acronyms. Nice to have: acronym list on article p.1 & numbers for cited works, not author names.https://t.co/mdtZGXZZVj

[Mirko von Elstermann @BiomedRevon]

I wish I had known about this resource earlier. "The Complex Portal is a manually curated, encyclopaedic resource of #macromolecular complexes from a number of key #modelorganisms." https://t.co/bPNCZvlNaz

[Complex Portal @complexportal]

#CotM: at the start of the year we look at the end of a cell's life: the #caspase cascade activates #apoptosis:
e.g. Casp-6 autocleaves or is cleaved by Casp-3,-8,-10 & cleaves Casp-2,-8,-10 and affects the apoptosome (incl. Casp-9):
https://t.co/5EwR8KFfrm

@PDBeurope #3p45

[Mirko von Elstermann @BiomedRevon]

#Statistics issues ('basic #reproducibility') so widespread in #biomedicine? 1 month's top-#physiology articles lack information about: #ANOVA details 95%, exact #pvalues 78%,#ttest type 53%.Also troubling: 61% used 1-factor ANOVA w/≥2-factor #studydesign.https://t.co/2ahGZ8M1hm

[Mirko von Elstermann @BiomedRevon]

#Stemcell state induction is #deterministic—shows experimentally constrained #networkmodelling. Apparent resetting randomness is due to exp./biol.(chromatin state…) variability. Same #geneticprogram controls SC maintenance,+redundant #genes for robustness.https://t.co/qYT1sw006h

[Mirko von Elstermann @BiomedRevon]

#mRNA (de)stabilization—cell response shortcut: IκB #kinases increase *more* transcripts’ degradation in P-bodies than genes' #transcription. But external stimuli may increase #phosphorylation of P-body proteins& stabilize mRNAs for rapid protein synthesis.https://t.co/wQMU5Qjq6j

[Mirko von Elstermann @BiomedRevon]

EXoO to catch an evasive PTM: Using the bacterial OpeRATOR enzyme (also: https://t.co/kdmONqkaln)+#massspec reveals many new protein O-glycosyation sites. In #kidneycancer, the met. details #glycosylation changes of #extracellularmatrix-remodeling proteins.https://t.co/YxvjqbHsZE

[Mirko von Elstermann @BiomedRevon]

#EndoplasmaticReticulum architecture @ XXXL res:#STEDmicroscopy shows ER 'fenestrations' are dynamic nanoholes coexisting with tubules & sheets. NHs may enable ER shape (+functional changes—e.g.,in #neurons) more rapidly than protein/lipid synthesis could.https://t.co/LncKIQFO34

[Zheng SHI (师征) @ZS_biophys]

Online now! GO READ IT!! #CellMembrane
Cell Membranes Resist Flow: Cell https://t.co/hCHY5SH09I

[Mirko von Elstermann @BiomedRevon]

New target to counter #tumor immune evasion: Siglec[#sialicacid-binding Ig-like #lectin]-9 on CD8+ #Tcells interacts w/#tumorcells' #sialoglycan self-antigens, blunting antitumor response. Both are increased in #lungcancer/#ovariancancer/#colorectalcancer. https://t.co/TLtNdEKvxA

[Mirko von Elstermann @BiomedRevon]

Opposite Ca activities def. #neuronal populations that code social salience or novelty.https://t.co/Gb7ahIvF0b. Confirms #Hebb?! if individ. neurons represent number symbols—https://t.co/x8mUvQ4pln? But by Hebbian Learning neurons may network to operate w/open no. sets (ℕ, ℤ…)

[Mirko von Elstermann @BiomedRevon]

Spoiler-teaser: "Our imaging method…provides a high-res. physical view of chromatin conformation of…genomic regions…[It] can complement seq.-based genome-wide met's for investigating chr. organization… [Combining both met's] …will help…understand the…[genomic] landscape…"

[Aziz Khan @khanaziz84]

Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells @sciencemagazine cc @ChromatinHaiku https://t.co/bQEtq0kVJQ

[Mirko von Elstermann @BiomedRevon]

Hyperprolific authors: 4-2002→81-2016. ½ life scientists. 1 author's response:"…some investigators seem impossibly short & some imposs. tall.…it’s the normal distri. curve w/people at each tail end. To people in the middle, each tail end will look improbable…I work 80hrs/wk."