Kashem

[Bryan Johnson @bryan_johnson]

This is it.
Everything learned spending millions on longevity.

From: Your Immortal Unc and Auntie.
To: Our Immortal nieces and nephews.

0. Sleep is the world's most powerful drug.
1. Be in your bed for 8 hours
2. Same bedtime every night, any time before midnight
3. Don’t eat right before bed
4. Calm foods for dinner
5. No screens 1 hour before bed
6. Avoid added sugar (be aware it’s in everything)
7. Avoid all things in an American convenience store
8. Avoid fried foods
9. Shoes off at the door
10. Eat whole foods, particularly veggies fruits nuts legumes berries
11. Walk a little after meals or air squats
12. Get your heart rate high routinely
13. Lift heavy things
14. Stretch daily
15. Water pik, floss, brush, tongue scrape, morning and night
16. Make an effort to drink water
17. Get sunlight when you wake up (UV is low)
18. Protect skin in midday sun
19. Stand up straight
20. See at least one friend once a week
21. Avoid plastic where you can (in all things)
22. Circulate air in rooms
23. When stressed, breathe, learn to calm your body
24. Go to the dentist
25. Avoid sitting for long times
26. Protect your hearing, the world is too loud
27. Alcohol is bad for you
28. Finish coffee before noon
29. Avoid bright lights after sunset
30. If obese, look into a GLP
31. Sleep in a cold room
32. Texting while driving is dangerous
33. Turn off all notifications
34. Limit social media use
35. Don’t smoke anything
36. If you struggle to sleep, read a physical book before bed
37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music
38. The body is a clock and loves routine. Have a daily morning and evening schedule.
39. Avoid long distance travel where you can
40. Baby steps first: incorporate new things slowly
41. Do less… most things don’t work.

Bonus points if you get your blood checked.

Start here, it will change your life.

[Dr Singularity @Dr_Singularity]

Retirement Dead

If you're under 50, there's no point in financial planning for your "retirement." The concept of retirement as we know it know won't exist in 15–20 years.

You’ll live comfortably whether you worked and saved for 40 years or were a bum living on the street, abundance will be so great that no one will be left behind. Some form of UBI will likely arrive well before 15–20 years.

What we call 'retirement' today is built on scarcity, on the assumption that you need decades of labor just to secure a few decades of rest. That model will start to break down once productivity is driven by systems that can operate at a scale and speed far beyond human limits(robotics driven by AGI's/ASI's).

When output becomes effectively abundant, the idea of "earning the right to stop working" stops making sense.

Work itself won't disappear, but it will become fluid, and driven more by interest than necessity. The line between working, learning, and living will blur.

Instead of saving for a distant endpoint, people will navigate continuous access to resources, services, and opportunities.

[Dr Singularity @Dr_Singularity]

We’re entering an era where abundance is no longer a dream. Energy, intelligence, materials, even biology, all scaling at exponential speeds.

Scarcity is being engineered out of the system.

When intelligence becomes abundant, innovation will compound, and when energy becomes abundant, production becomes almost limitless.

[Kashem @Biplob_Azad]

@elonmusk I just finished my first-ever animation videos! It’s wild being able to turn my imagination into actual visuals thanks to @grok

[Elon Musk @elonmusk]

Macrohard or Digital Optimus is a joint xAI-Tesla project, coming as part of Tesla’s investment agreement with xAI.

Grok is the master conductor/navigator with deep understanding of the world to direct digital Optimus, which is processing and actioning the past 5 secs of real-time computer screen video and keyboard/mouse actions. Grok is like a much more advanced and sophisticated version of turn-by-turn navigation software.

You can think of it as Digital Optimus AI being System 1 (instinctive part of the mind) and Grok being System 2. (thinking part of the mind).

This will run very competitively on the super low cost Tesla AI4 ($650) paired with relatively frugal use of the much more expensive xAI Nvidia hardware. And it will be the only real-time smart AI system. This is a big deal.

In principle, it is capable of emulating the function of entire companies. That is why the program is called MACROHARD, a funny reference to Microsoft.

No other company can yet do this.

[Dr. Rhonda Patrick @foundmyfitness]

Using the sauna after aerobic exercise improves VO₂ max more than training alone.

People who performed 30 minutes of cycling and then sat in a sauna for ~15 minutes afterward saw greater gains in their VO₂ max after 8 weeks of training compared to those who did the workout without sauna.

There’s also emerging evidence for strength training, with studies showing greater increases in markers of anabolic signaling associated with muscle growth with post-exercise heat exposure.

The sauna has several health benefits. But it's also a powerful tool to amplify the body's adaptations to both endurance and strength training.

Clip from my recent appearance on @ThomasDeLauer

[BraVoCycles Newsletter @BraVoCycles]

🚨 Record TLT Short Positioning

Once TLT bottoms and reverses, a short squeeze could be violent.

Interested in knowing when to expect a TLT bottom?
Retweet, and I'll DM you the TLT cycle projection (must follow).

[Kashem @Biplob_Azad]

The Red Dragon

[Bryan Johnson @bryan_johnson]

We’ve spent decades treating lithium as a heavy duty psychiatric tool. New evidence suggests it’s actually a foundational brain nutrient and that Alzheimer’s may essentially be a localized lithium deficiency.

By using the Orotate salt, we can bypass plaque-induced transport blocks and restore brain levels with 1mg.

I’ve been supplementing low dose (1mg/day) lithium for years. More evidence now suggests it was the right decision.

Here’s why lithium is potentially beneficial and how we arrived at this decision years ago.

The study unequivocally demonstrated lithium deficiency in the brains of patients with cognitive impairment, providing mechanistic evidence of its role as a driver of disease onset and progression.

It validated our choice of Lithium Orotate as the optimal form of lithium supplementation for preventing and slowing the progression of dementia.

Lithium has long been a foundational ingredient in my protocol, utilized in a low-nutritional dose. This was based on our comprehensive analysis of various population studies supporting its safety and potential benefits for brain health and mental well-being.

Establishing a direct mechanistic link: beyond its known effects on mood and well-being, the study forged a direct and mechanistic and progressive connection between lithium brain deficiency and cognitive impairment, including Alzheimer's disease.

Optimal form of lithium: the study revealed that lithium orotate, the specific form of lithium salt I have been using for years, is superior in avoiding blockage by existing plaque, thereby achieving the highest bioavailability, greatest plaque reduction, and cognitive restoration in previously lithium-deficient mice with pre-existing cognitive impairment.

[Elon Musk @elonmusk]

Try the “extend video” feature of @Grok Imagine. You can make a whole story.

[DogeDesigner @cb_doge]

BREAKING: 𝕏 just launched Creator Subscriptions 2.0!

New easy tools to help creators earn more and grow faster.

• Exclusive Threads – Lock parts of your thread for subscribers only (tease publicly, paywall the rest)

• New Share Cards – Beautiful auto cards to promote your subscriptions anywhere on X

• Upgraded Paywalls – Shows your perks upfront so fans instantly see the value

• Subs-Only on Profiles – Exclusive content now appears right in your main profile feed

• New Dashboard – Simple earnings tracker + clear subscriber insights.

Better discovery, more conversions, all staying on X!

[Dan Go @CoachDanGo]

This workout is simple:

You walk 3 miles per hour on a 12-level incline for 30 minutes.

It sounds easy until minute 3 when your legs start negotiating with your brain.

But here's the thing, that burn, it's doing something real:

[Dr Singularity @Dr_Singularity]

No matter how old you are, soon you’ll look like you’re 20-25. Below is proof that we’re making progress toward it.

Scientists at NYU School of Medicine have uncovered a key cause of aging skin, and how to reverse it, at least in mice.

They discovered that capillary associated macrophages (CAMs), immune cells that maintain tiny blood vessels, decline with age, leading to poorer blood flow and slower healing.

Using live imaging and genetic tools, researchers watched this happen in real time, showing how microvascular repair falters as macrophages vanish.

Then came the breakthrough, a short growth factor treatment (CSF1–Fc) boosted macrophage renewal, restoring microvascular repair and blood flow in aged skin.

!
Human samples revealed the same age linked macrophage loss, hinting that a similar rejuvenation might work in people.

In short - aging skin may be partially reversible, not by stretching or resurfacing it, but by repopulating its microscopic immune vascular network.

[_aestheticprimal_ @aestheticprimal]

The reason why athletes see a MUCH bigger increase in Testosterone levels from Magnesium supplementation is because Magnesium helps offset the excessive Calcium ion influx.

As well as the fact that exercise itself strongly depletes Magnesium levels.

[Simon Maechling @simonmaechling]

Cancer patients who got a COVID shot lived significantly longer.

No, that’s not a typo.

A new study found that a simple mRNA vaccine - originally made for COVID - nearly doubled survival in patients with advanced lung and skin cancer.

Let’s break it down 👇 🧵 1/

[Shining Science @ShiningScience]

A new vaccine shows promise in preventing up to 88% of aggressive cancers like melanoma, pancreatic cancer, and triple-negative breast cancer, according to a recent study from researchers at University of Massachusetts Amherst.

Using tiny lipid nanoparticles packed with two immune-boosting molecules, the vaccine trains both arms of the immune system to recognize and destroy tumor cells. These nanoparticles trigger a fast, general response from the innate immune system and a slower, more targeted attack from the adaptive immune system, which creates memory for long-term protection.

In tests on mice, the vaccine was injected under the skin on a schedule of three doses and paired with either tumor-specific peptides or full tumor protein mixtures. When tested against three challenging cancer types, the results were striking: mice receiving the full vaccine completely rejected tumors, while untreated mice or those with a single adjuvant died within weeks.

Even more impressive, mice that survived the first round stayed tumor-free when re-exposed to cancer months later, showing strong immune memory. The particles effectively reached lymph nodes, critical sites for triggering immune responses, and activated key messenger cells that stimulate both T cells and B cells, the main players in killing cancer cells and remembering them.

When the vaccine used whole tumor lysate instead of isolated peptides, it still protected 69% to 88% of mice across all cancer types tested, and all vaccinated mice survived a second cancer challenge. This broad protection suggests the vaccine could work across multiple cancers, not just one.

[_aestheticprimal_ @aestheticprimal]

Mineralization speeds up Masculinization

Boron → lowers SHBG, increases 5α-r
Zinc → lowers SHBG, inhibits Aromatase
Magnesium → steroidgenesis enzymes
Calcium → lowers PTH, upregulates StAR
Selenium → Leydig cell sensitivity, LH

[Dr Singularity @Dr_Singularity]

Scientists restored the brain’s waste clearing gateway in Alzheimer’s like mice, reducing plaques by 45% and reversing memory loss after three nanoparticle injections.

The treatment repairs the blood brain barrier instead of bypassing it, an approach researchers call a potential 'new era' in Alzheimer’s therapy.

[Siim Land @siimland]

Boron is the superhero mineral you're not getting enough of:

- helps bone mineralization
- improves vitamin D
- improves testosterone/estrogen status
- increases antioxidant defense
- reduces inflammation
- reduces calcium/magnesium loss