Murray Blackmore

The Blackmore lab discovers novel molecular mechanisms that control nerve regeneration, and uses that information to promote repair after spinal cord injury.

[Murray Blackmore @Blackmorelab]

This is very exciting! Thanks to @SpinalResearch for supporting this critical effort to get the science out to the people that need it.

[Spinal Research @SpinalResearch]

We’re proud to announce that we’ve co-founded SCI Ventures, the first venture philanthropy fund focused on innovative therapies for people living with spinal cord injury.

Read more about the launch here: https://t.co/gJ8IR71kW0

#SCIVentures #paralysis #philanthrophy

[Murray Blackmore @Blackmorelab]

See our latest preprint! Sometimes it's what DOESN'T happen that matters most. Meaning - in the Mysterious Case of the Axons That Won't Regenerate, there is a dog that didn't bark. Great collab with @Ishwariya13 @FreglisPlethon
https://t.co/wGuOEVI6mU

[Murray Blackmore @Blackmorelab]

@DulinJen Well if it’s any consolation you beat mine by two percentage points.Thanks for posting this and hang tough.

[Murray Blackmore @Blackmorelab]

This is a great lab in a great environment, spread the word

[Geoffroy Lab @GeoffroyLab]

Interested in understanding how gastro-intestinal complications occur after spinal cord injury? We're hiring! Join the lab and help us study this major health complication for people living with a spinal injury! https://t.co/hsUy9Uw2fP

[Murray Blackmore @Blackmorelab]

And now the companion paper to https://t.co/NkFyKGqcyw. The Elife paper mapped the supraspinal anatomy, now we provide corresponding transcription by snRNA-Seq. Marker genes for all your favorite descending cell types! @FreglisPlethon

https://t.co/AtNKVc58Jo

[Murray Blackmore @Blackmorelab]

Very proud to share the final version of work with @FreglisPlethon, mapping the supraspinal connectome in mice before and after injury. https://t.co/NkFyKGqcyw

Also check out https://t.co/vqenxL9P5x for interactive 3D data!

[Murray Blackmore @Blackmorelab]

@DautanDaniel Ha! So true. It has been fun but humbling to “discover” all these supraspinal nuclei that really were characterized so long ago. We tried to point to the early work throughout the paper. @FreglisPlethon is amazing at that, he has read so much.

[Murray Blackmore @Blackmorelab]

More collaboration with @FreglisPlethon! We present a resource to visualize and count tens of thousands of supraspinal neurons across the mouse brain. https://t.co/zi1zLc7Qzu. Website here: https://t.co/HPLt5l1o9J The thread explains why I think we need this!

[Murray Blackmore @Blackmorelab]

@DautanDaniel Yes, exactly! Honestly the PPN wasn’t on my radar until it popped out of the locomotion / sparing correlation analysis in our study. Looks like you were a step ahead 👍

[Murray Blackmore @Blackmorelab]

@brettjhilton Thanks! This project was fun and I'm excited to develop it more. File sizes aren't terrible, to give you an idea we group each brain's inputs and outputs in a folder and those total about 50-70GB each. But multiply by ~100 brains and it does add up...

[Murray Blackmore @Blackmorelab]

I can’t emphasize enough how great @brain_globe is, both the tools themselves and the open science in action.

[Murray Blackmore @Blackmorelab]

I believe these brain-wide data are a must-have to interpret behavior and to predict the translational prospects of treatments for more diverse functions. But you decide! Check out the preprint and website and let us know what you think.

[Murray Blackmore @Blackmorelab]

But now with bright viral label, tissue clearing, automated cell detection, and digital registration, it is practical – I emphasize practical – to see and measure all supraspinal populations in one shot, in replicate animals after injury and treatment.

[Ishwariya Venkatesh @Ishwariya13]

I have shied away from Twitter given the bleak COVID news in India but this news cuts through the gloom, even if just a bit. My paper with @Blackmorelab “Co-occupancy identifies transcription factor cooperation for axon growth” is live at @NatureComms https://t.co/Msf45KY1fh

[Murray Blackmore @Blackmorelab]

A really nice paper! Read the discussion carefully, you can see where they are headed, and it sounds pretty interesting...

[Cafferty Lab @CaffertyLab]

Thrilled to share our latest study hinting at limb specific axon growth regulators - more to come! https://t.co/V94HPoC2Gr

[Murray Blackmore @Blackmorelab]

https://t.co/DMyYFpue7F I am happy to share our latest - new gene combinations for axon growth in the CNS, a joint project with @Ishwariya13 . Also a good time to mention we are hiring a postdoc! The next big discovery could be yours! More at https://t.co/OK6XXurBUI