Bruno Lorenzo 🫑

[Claude @claudeai]

Introducing Claude Fable 5: a Mythos-class model that we’ve made safe for general use.

Its capabilities exceed those of any model we’ve ever made generally available.

[Sam Altman @sama]

OpenAI Robotics is hiring, looking for exceptional full-stack hardware, ops, systems, and ML engineers to help us program and manufacture robots that are useful for society.

AI should be able to help people in the physical world. In the short term, we are focused on robots to support skilled workers to build our future infrastructure; in the long term, we imagine everyone having a personal robot doing anything they need.

Our world simulation research program, led by Aditya Ramesh (@model_mechanic), has evolved over the past year into OpenAI Robotics. Progress is rapid, and based on a foundation of co-design between robotics hardware and ML research.

If you love working hands-on across the robotics stack and want to build the future, please consider joining us. Send an email with your background and evidence of exceptional accomplishment to: [email protected]

[Andrej Karpathy @karpathy]

Personal update: I've joined Anthropic. I think the next few years at the frontier of LLMs will be especially formative. I am very excited to join the team here and get back to R&D. I remain deeply passionate about education and plan to resume my work on it in time.

[Isomorphic Labs @IsomorphicLabs]

Today marks a pivotal moment for Isomorphic Labs. We have secured $2.1 Billion in our second external funding round, led by Thrive Capital. They are joined at the table by Alphabet, GV and new investors MGX, Temasek, CapitalG and the UK Sovereign AI Fund.

This milestone accelerates our ability to build the pioneering novel AI models that power our AI drug design engine (IsoDDE) and deploy them at scale: delivering scientific breakthroughs with a precision previously thought impossible, accelerating and expanding our pipeline of therapeutic programs toward the clinic. All with the ultimate goal of delivering life-changing new medicines to patients.
Moving forward, we will scale our drug candidate pipelines across multiple therapeutic areas, expand our global footprint, and push the boundaries of frontier AI research to power our drug design engine.
Deeply grateful to everyone sharing our vision to solve all disease with AI. Let’s build the future of medicine.

Read the full announcement here: https://t.co/TtXk3xqA84

[Bruno Lorenzo 🫑 @Brunolg9]

Flipbook shows a possible next step for the internet: not using prebuilt software, but interfaces that the model generates in real time based on what you want to do!

[Zain Shah @zan2434]

Imagine every pixel on your screen, streamed live directly from a model. No HTML, no layout engine, no code. Just exactly what you want to see.

@eddiejiao_obj, @drewocarr and I built a prototype to see how this could actually work, and set out to make it real. We're calling it Flipbook. (1/5)

[Dani @danitoszwarc]

El tweet de
@miriamgonp me empujó hacia la IA orientada a la salud. @javilop pasó una semana aplicando IA al historial médico de Míriam y compartió su metodología. Yo lo hice app. MedSynth: análisis adversarial para historiales médicos complejos. https://t.co/xcY9km97dj

[Claude @claudeai]

Introducing Claude Managed Agents: everything you need to build and deploy agents at scale.

It pairs an agent harness tuned for performance with production infrastructure, so you can go from prototype to launch in days.

Now in public beta on the Claude Platform.

[Javi López ⛩️ @javilop]

It's Game Over.

Todos los que critican que el Vibecoding crea código de mierda imposible de mantener no se dan cuenta de que en menos de un par de años, solo con pedirlo, la IA podrá refactorizar proyectos de 100k líneas o más incluyendo librerías y optimizar cualquier cosa mejor que los mejores expertos del mundo... Como si pides que te lo pase a ensamblador... Como si lo quieres codificado en canicas de colores 😂

La programación es un medio, no un fin. Hemos subido de capa de abstracción.

[Míriam González @miriamgonp]

El farmaco Imlunestrant para cancer de mama metastásico, está aprobado en Europa por la EMA y pendiente de financiación en España. La normativa sugiere 180 días para su aprobación pero en España tenemos demora de entre 3 y 4 años.

Yo lo necesito ya y no puedo acceder a él 🫠

[Míriam González @miriamgonp]

Tengo 35 años y cancer de mama metastásico, un caso raro, menos del 1% de tumores de mama son como el mío y hay poca documentación sobre ello.

Por eso me gustaría encontrar personas que se dediquen a esto y que quieran investigar con mi caso. Twitter haz tu magia

[Javi López ⛩️ @javilop]

🔴 NECESITO TU ATENCIÓN

Llevo una semana ayudando a Miriam en su caso de cáncer metastásico y quiero compartir la metodología que he estado usando porque es absolutamente replicable.

Pienso que, con suerte, puede ser ÚTIL A OTRAS PERSONAS con cáncer (o con cualquier otra enfermedad).

Los resultados que hemos conseguido no son un milagro, pero pensamos que son realmente útiles y pueden significar una diferencia crucial en un caso médico de vida o muerte.

Aquí va paso a paso el método:

1/ Usar los modelos más avanzados del momento (por desgracia de pago, y no son baratos, opino que Sanidad Pública debería invertir en esto):

- ChatGPT Pro + Extended (40min de pensamiento aprox por llamada)
- Claude Opus 4.6 MAX

Pendientes de probar a fondo:
- Perplexity Sonar Pro
- Notebook LM

2/ Dárselo MUY MASCADO a la IA todo el historial. Esto parece una tontería pero es muy importante.

- Lo primero que pido, con Claude Cowork que tiene acceso al disco duro, es que entre en la carpeta en la que está TODO EL HISTORIAL (pueden ser más de 100 pdfs) y lo unifique todo en:
- Un único PDF (puede ser de más de 1000 páginas o lo que sea necesario)
- Un único txt legible, que debe hacer correctamente usando un script con OCR y luego comprobar con lupa que está bien hecho.

Insisto: no saltar al siguiente paso antes de tener muy bien hecho lo anterior, sobre todo el txt.

3/ Una vez tenemos lo anterior utilizar este prompt junto con el txt y el PDF como archivos de entrada y lanzarlo en AMBOS modelos (y en más si es posible) a la vez.

👉 Os lo dejo aquí, este prompt es increíble complejo/avanzado: https://t.co/KEEWc8WNvW Está pensado para el caso concreto de Miriam, pero con los modelos del punto 1/ podrías adaptarlo a tu caso particular sin problemas.

4/ La PUNTA DE FLECHA enfrentando un modelo al otro: esta metodología no la he escuchado a nadie, pero funciona increíblemente bien. La sensación es la de ir afilando una estaca hasta que adquiere una punta reluciente.

Funciona así: con paciencia y en sucesivas iteraciones (aconsejo mínimo 5 veces, y en en cuenta que si ChatGPT tarda 40min te va a llevar un buen rato) enfrenta el resultado (el PDF) de un modelo a otro. Con un prompt sencillo del estilo:

"Otro comité de expertos opina esto. ¿Cómo lo ves? Si estás de acuerdo o lo contrario dime por qué, y genera un nuevo PDF si lo ves preciso".

El resultado se lo cruzas al modelo contrario. Así, en sucesivas iteraciones, búsquedas de internet, papers, etc. irán encontrando y afilando más cosas.

¿Cuándo acabar? Cuando AMBOS modelos digan que está perfecto y no puedan mejorar más el trabajo del contrario. Esto es tan absurdamente rompedor que pienso que los resultados de TODOS los modelos actuales mejorarían si siguieran esta metodología (apoyándose en una espiral rollo "adversarial model". No entiendo por qué nadie se ha dado cuenta de esto, si lo ha hecho, por qué no se le da más bombo. Funciona impresionantemente bien en cualquier ámbito, inclusive programación y matemáticas.

Es mas, mi teoría es que esto podría hacerse todavía mejor haciéndolo no solo con dos modelos: sino con una mayor combinatoria, añadiendo quizás Perplexity Sonar Pro, etc.

RESULTADOS

Increíbles. Obviamente no puedo saber si mejores que el mejor de los comités científico-sanitarios del mundo, pero le están dando a Miriam una nueva dimensión del caso, tests adicionales que hacer, posibles pruebas, etc.

Obviamente la IA milagros no hace, pero pienso que puede ya, a día de hoy, ayudar a muchos pacientes. Y Sanidad Pública debería invertir mucho, pero mucho, en esto.

Voy a preguntarle a Miriam si puedo poner el PDF completo de resultados más avanzado que conseguimos, para que os hagáis una idea de su calidad. Ya me ha dado más o menos permiso, pero quiero asegurarme 100%.

[Bruno Lorenzo 🫑 @Brunolg9]

@Inversoracon30 Rías Baixas
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Hogar Gallán Alojamiento

Top 👌

[Bruno Lorenzo 🫑 @Brunolg9]

Okay... That's interesting... :s

[jack @jack]

we're making @blocks smaller today. here's my note to the company.

####

today we're making one of the hardest decisions in the history of our company: we're reducing our organization by nearly half, from over 10,000 people to just under 6,000. that means over 4,000 of you are being asked to leave or entering into consultation. i'll be straight about what's happening, why, and what it means for everyone.

first off, if you're one of the people affected, you'll receive your salary for 20 weeks + 1 week per year of tenure, equity vested through the end of may, 6 months of health care, your corporate devices, and $5,000 to put toward whatever you need to help you in this transition (if you’re outside the U.S. you’ll receive similar support but exact details are going to vary based on local requirements). i want you to know that before anything else. everyone will be notified today, whether you're being asked to leave, entering consultation, or asked to stay.

we're not making this decision because we're in trouble. our business is strong. gross profit continues to grow, we continue to serve more and more customers, and profitability is improving. but something has changed. we're already seeing that the intelligence tools we’re creating and using, paired with smaller and flatter teams, are enabling a new way of working which fundamentally changes what it means to build and run a company. and that's accelerating rapidly.

i had two options: cut gradually over months or years as this shift plays out, or be honest about where we are and act on it now. i chose the latter. repeated rounds of cuts are destructive to morale, to focus, and to the trust that customers and shareholders place in our ability to lead. i'd rather take a hard, clear action now and build from a position we believe in than manage a slow reduction of people toward the same outcome. a smaller company also gives us the space to grow our business the right way, on our own terms, instead of constantly reacting to market pressures.

a decision at this scale carries risk. but so does standing still. we've done a full review to determine the roles and people we require to reliably grow the business from here, and we've pressure-tested those decisions from multiple angles. i accept that we may have gotten some of them wrong, and we've built in flexibility to account for that, and do the right thing for our customers.

we're not going to just disappear people from slack and email and pretend they were never here. communication channels will stay open through thursday evening (pacific) so everyone can say goodbye properly, and share whatever you wish. i'll also be hosting a live video session to thank everyone at 3:35pm pacific. i know doing it this way might feel awkward. i'd rather it feel awkward and human than efficient and cold.

to those of you leaving…i’m grateful for you, and i’m sorry to put you through this. you built what this company is today. that's a fact that i'll honor forever. this decision is not a reflection of what you contributed. you will be a great contributor to any organization going forward.

to those staying…i made this decision, and i'll own it. what i'm asking of you is to build with me. we're going to build this company with intelligence at the core of everything we do. how we work, how we create, how we serve our customers. our customers will feel this shift too, and we're going to help them navigate it: towards a future where they can build their own features directly, composed of our capabilities and served through our interfaces. that's what i'm focused on now. expect a note from me tomorrow.

jack

[jack @jack]

we're making @blocks smaller today. here's my note to the company.

####

today we're making one of the hardest decisions in the history of our company: we're reducing our organization by nearly half, from over 10,000 people to just under 6,000. that means over 4,000 of you are being asked to leave or entering into consultation. i'll be straight about what's happening, why, and what it means for everyone.

first off, if you're one of the people affected, you'll receive your salary for 20 weeks + 1 week per year of tenure, equity vested through the end of may, 6 months of health care, your corporate devices, and $5,000 to put toward whatever you need to help you in this transition (if you’re outside the U.S. you’ll receive similar support but exact details are going to vary based on local requirements). i want you to know that before anything else. everyone will be notified today, whether you're being asked to leave, entering consultation, or asked to stay.

we're not making this decision because we're in trouble. our business is strong. gross profit continues to grow, we continue to serve more and more customers, and profitability is improving. but something has changed. we're already seeing that the intelligence tools we’re creating and using, paired with smaller and flatter teams, are enabling a new way of working which fundamentally changes what it means to build and run a company. and that's accelerating rapidly.

i had two options: cut gradually over months or years as this shift plays out, or be honest about where we are and act on it now. i chose the latter. repeated rounds of cuts are destructive to morale, to focus, and to the trust that customers and shareholders place in our ability to lead. i'd rather take a hard, clear action now and build from a position we believe in than manage a slow reduction of people toward the same outcome. a smaller company also gives us the space to grow our business the right way, on our own terms, instead of constantly reacting to market pressures.

a decision at this scale carries risk. but so does standing still. we've done a full review to determine the roles and people we require to reliably grow the business from here, and we've pressure-tested those decisions from multiple angles. i accept that we may have gotten some of them wrong, and we've built in flexibility to account for that, and do the right thing for our customers.

we're not going to just disappear people from slack and email and pretend they were never here. communication channels will stay open through thursday evening (pacific) so everyone can say goodbye properly, and share whatever you wish. i'll also be hosting a live video session to thank everyone at 3:35pm pacific. i know doing it this way might feel awkward. i'd rather it feel awkward and human than efficient and cold.

to those of you leaving…i’m grateful for you, and i’m sorry to put you through this. you built what this company is today. that's a fact that i'll honor forever. this decision is not a reflection of what you contributed. you will be a great contributor to any organization going forward.

to those staying…i made this decision, and i'll own it. what i'm asking of you is to build with me. we're going to build this company with intelligence at the core of everything we do. how we work, how we create, how we serve our customers. our customers will feel this shift too, and we're going to help them navigate it: towards a future where they can build their own features directly, composed of our capabilities and served through our interfaces. that's what i'm focused on now. expect a note from me tomorrow.

jack

[Andrej Karpathy @karpathy]

It is hard to communicate how much programming has changed due to AI in the last 2 months: not gradually and over time in the "progress as usual" way, but specifically this last December. There are a number of asterisks but imo coding agents basically didn’t work before December and basically work since - the models have significantly higher quality, long-term coherence and tenacity and they can power through large and long tasks, well past enough that it is extremely disruptive to the default programming workflow.

Just to give an example, over the weekend I was building a local video analysis dashboard for the cameras of my home so I wrote: “Here is the local IP and username/password of my DGX Spark. Log in, set up ssh keys, set up vLLM, download and bench Qwen3-VL, set up a server endpoint to inference videos, a basic web ui dashboard, test everything, set it up with systemd, record memory notes for yourself and write up a markdown report for me”. The agent went off for ~30 minutes, ran into multiple issues, researched solutions online, resolved them one by one, wrote the code, tested it, debugged it, set up the services, and came back with the report and it was just done. I didn’t touch anything. All of this could easily have been a weekend project just 3 months ago but today it’s something you kick off and forget about for 30 minutes.

As a result, programming is becoming unrecognizable. You’re not typing computer code into an editor like the way things were since computers were invented, that era is over. You're spinning up AI agents, giving them tasks *in English* and managing and reviewing their work in parallel. The biggest prize is in figuring out how you can keep ascending the layers of abstraction to set up long-running orchestrator Claws with all of the right tools, memory and instructions that productively manage multiple parallel Code instances for you. The leverage achievable via top tier "agentic engineering" feels very high right now.

It’s not perfect, it needs high-level direction, judgement, taste, oversight, iteration and hints and ideas. It works a lot better in some scenarios than others (e.g. especially for tasks that are well-specified and where you can verify/test functionality). The key is to build intuition to decompose the task just right to hand off the parts that work and help out around the edges. But imo, this is nowhere near "business as usual" time in software.

[Bruno Lorenzo 🫑 @Brunolg9]

@javilop Al cambio te compensan los tokens 😅💱

[Neil Houlsby @neilhoulsby]

🚨 New roles at Anthropic Zurich 🇨🇭

In addition to pre-training (where we've been hiring so far), post-training and security are joining and have open roles!

It's a remarkable time in AI, the company, and on the site.

https://t.co/wJEITx2Vqo

[Bruno Lorenzo 🫑 @Brunolg9]

If you could generate your own GTA world, what’s the first place you’d build: your street, your hometown, or somewhere totally made up? ⚠️

[Bruno Lorenzo 🫑 @Brunolg9]

Wait…This is basically every kid dream coming to life...

We are getting to the point where you can generate your own GTA… in your own town!! My dream :'o

Rockstar Games vs Google Genie 3 jajaja

[Ssam Moussaoui @ssamoussaoui]

Google latest AI makes u generate games in a couple of minutes. that's mad crazy.

GTA 6 Greenland Edition.

it is definitely the end of the gaming studios.

[Bruno Lorenzo 🫑 @Brunolg9]

One day you’ll be driving around your neighborhood, pulling up to your supermarket, roaming your streets… in a world you basically created with a prompt.

It’s early days (more interactive demo than game), but… yeah. The dream is showing up in public now. 🤯