Brya Matthews

Kiwi, bone biology nerd and (wannabe) traveller

[Brya Matthews @BryaMatthews]

@NIH Sincerely hope these savings go into improving success rates for grants and funding existing projects in full!

[Brya Matthews @BryaMatthews]

@NIH It always seemed problematic that some of the wealthiest institutions got the highest overheads, but I suspect they’re still reasonable compared with what a lot of consultants charge the government!

[Brya Matthews @BryaMatthews]

@DrDzenitaM Nice, I was pretty surprised when we started doing microbiology how 'old school' a lot of the methods are! Like my undergrad labs from longer ago than I'd like to admit were actually relevant

[Brya Matthews @BryaMatthews]

Great talk @NatalieASims. I have a question. Mice are clearly not ideal for studying coupling. What sort of models would you like to see used to better elucidate the role of these putative coupling factors in the BMU?

[Brya Matthews @BryaMatthews]

View from the chairs’ table at the skeletal stem cell session this morning #ASBMR2023

[Brya Matthews @BryaMatthews]

@cblenkie How did you know??? He’s so appealing to my demographic

[Brya Matthews @BryaMatthews]

Uploaded my #vote for the NZ election from JFK airport. Love how straightforward it is to vote from overseas🙂

[Brya Matthews @BryaMatthews]

@Ye_Cao_ @AnnaBoss100 @DrAnnaNZ Whoops, forgot @hcmurray6 for lending your immunostaining expertise and reagents!

[Brya Matthews @BryaMatthews]

Our paper looking at skeletal cell populations in adult human tissue, particularly the periosteum is out in Bone! https://t.co/iHHyXzTu5V
We did a large spectral flow panel on matched samples from 21 patients and find that the periosteum looks very different overall from the BM

[Brya Matthews @BryaMatthews]

Congratulations to @Ye_Cao_ for doing most of the work (and defending your thesis!!!). Thanks to @AnnaBoss100 and @DrAnnaNZ for helping get the flow panel and analysis going, and Scott, Nicola, Raewyn and the surgeons for making sure we could get plenty of hips.

[Brya Matthews @BryaMatthews]

@KokubunTakanori @Bone_Healing @RobertMauck11 @jboerckel @DymentLabPenn Ivo is 'admiring' the stunning location @Bone_Healing 😆Great to see you all and see some of you again soon in Vancouver

[Brya Matthews @BryaMatthews]

And thanks to @AucklandUni library CAUL agreement the paper is open access 😃

[Brya Matthews @BryaMatthews]

We think this population needs to be refined further, but looks like a good starting point for enriching for periosteal stem/progenitors in adult humans

[Brya Matthews @BryaMatthews]

We also found that the CD90+CD34+ population in periosteum is enriched for cells with in vitro stem/progenitor properties (CFU-F formation, clonal trilineage differentiation, tertiary colony formation)

[Brya Matthews @BryaMatthews]

Articular cartilage has surprisingly high % of markers we expected to be enriched in stem cells, and performs remarkably well in CFU-F assays

[JBMRPlus @JBMRPlus]

A recent study in #JBMRPlus sought to uncover the impact of preptin KO in mice on the response to a moderately high-fat diet (HFD) and low-fat diet (LFD) @EmmaBuckels @BryaMatthews @WileyHealth #OpenAccess #ASBMR

https://t.co/sgvjJ5YiFA

[Brya Matthews @BryaMatthews]

@dr_benomycin Oh yeah no problem, stop ignoring them Ben! 😩

[Brya Matthews @BryaMatthews]

@rhbloomer Interesting, although I feel like there are definitely situations where people ‘sponsor’ others with diversity in mind. I think I’ve been invited to be on editorial boards by overseas colleagues in part because someone from NZ adds diversity

[Brya Matthews @BryaMatthews]

Excited that this work we were involved with is out in Nature Aging. This drug extends lifespan and healthspan in male and female mice. Bones didn't look so good, so more research to be done!

[Peter Shepherd @ShepherdPeterR]

It’s been a long time coming but our paper showing long term beneficial effects of inhibitors targeting PIK3CA is out today. Awesome effort by Chris Hedges ⁦who did most of work and lead by ⁦@TMerry_NZ⁩ with input from many other NZ researchers. https://t.co/c82Z9RP7pj

[Brya Matthews @BryaMatthews]

@ColinHisey @NIBIBgov @robotsmarts @DrMonicaCox @OSUengineering Congratulations Colin, fantastic news!