Bursac Lab

cardiac & skeletal muscle tissue engineering, differentiation of pluripotent stem cells into striated muscle cells, and ephys of excitable cells and tissues

[Bursac Lab @BursacLab]

Our newest paper "Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure" was just released in
@ScienceAdvances! Check it out here:
https://t.co/DkUl07srkj

[JAHA @JAHA_AHA]

Inducing stable polyploidy in human iPSC-derived cardiomyocytes affects their transcriptome, cell cycling, and function. #AHAJournals #ResearchLetter @BursacLab https://t.co/KuQ4CIXjC8

[Bursac Lab @BursacLab]

Our newest paper, "Effects of Pharmacological Polyploidization in Human iPSC‐Derived Cardiomyocytes", was just released in the Journal of the American Heart Association! @JAHA_AHA
Check it out:
https://t.co/UmgsVjai53

[Bursac Lab @BursacLab]

Our new publication "BacNav Gene Therapy Improves Function of Infarcted Engineered Human Myocardium and NHPs" was released in Circulation Research! @CircRes
Check out the article and press release below:
https://t.co/b305zCJkht
https://t.co/Xzokm84GBE

[Muscle Cell News @musclecellnews]

For the first time, @DukeU researchers including Torie Broer generated in vitro robustly vascularized, highly functional engineered human skeletal muscle tissues, that mimicked in vivo satellite cell abundance and density. 🛰️

https://t.co/VDpTkL5JLt

[Muscle Cell News @musclecellnews]

⚗️Dr. Alastair Khodabukus and colleagues, describe the first 3D tissue-engineered hiPSC-derived #SkeletalMuscle model of LGMD2B.

The model exhibits compromised contractile function, calcium handling, membrane repair 🩹 among other features. @BursacLab

https://t.co/YAKSLuR8o9

[Bursac Lab @BursacLab]

How is muscle replaced with fat in patients with limb girdle muscular dystrophy 2B? Our most recent work uses 3D engineered skeletal muscle to explore the molecular mechanisms at play in this untreatable disease.
https://t.co/5OIJUlT5Ty
@JainFoundation @DukeEngineering

[Bursac Lab @BursacLab]

Our newest publication "Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy" was just released in Advanced Science! @AdvSciNews
Check it out here:
https://t.co/Gb59NS7FVn

[Bursac Lab @BursacLab]

Can we use cancer's tricks to help make a non-regenerative organ grow? Our newest paper explores how a common skin cancer mutation can encourage heart cells to multiply.
https://t.co/ZYDFlQ7bck

[Bursac Lab @BursacLab]

Our newest paper "Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium" was just released in @ScienceAdvances!
Check it out here: https://t.co/dfPMQSxl3W

[Bursac Lab @BursacLab]

Congratulations to the Bursac Lab members recognized at the
@DukeEngineering BME Retreat!
Marisa - TA excellence award
Abbi - 1st place rapid-fire talk
Torie - TA of the Year award
Amber - NSF GRFP awardee

[Somatic Cell Genome Editing (SCGE) Outreach @somaticediting]

#PublicationFriday📚 #SCGE PI Dr. Nenad Bursac (@BursacLab) and his team observe satellite cells, cells responsible for #muscle repair, to address muscle degeneration human
https://t.co/FPD1BBCJrk
@dukebiochem

[Bursac Lab @BursacLab]

The Bursac Lab is hiring!
Join our team as an Associate in Research focused on skeletal muscle biology and regeneration.

https://t.co/EgY64saqxp

[Jacob Scherba @JCScherba]

This one has been a labor of (mostly) love over the last 2.5 years or so, and I'm so happy to be able to share it now. Grateful to Dr. Glass,@Marc_Halushka, @APLandstrom, @joemaleszewski, Dr. Andersen, and @BursacLab 🫀
https://t.co/zOrXRhBiZf

[Bursac Lab @BursacLab]

We had amazing weather for Yifan's going away lunch today! We will miss you Yifan, but we know you will make us proud in your MD-PhD program!

[Bursac Lab @BursacLab]

'Exciting' news about our work to develop a voltage-gated sodium channel platform for cardiac gene therapy!
https://t.co/oNcnMnOA9Q

[Bursac Lab @BursacLab]

Our most recent publication highlights our work optimizing the delivery route for cardiac regenerative therapeutics
https://t.co/dUnGDs4n1E
@FrontCVMedicine

[Andrew Vekstein, M.D. @AndrewVekstein]

Just one piece of years of collaboration led by @BursacLab, Adam Williams, Dawn Bowles and many others and supported by Translating Duke Health (@DukeMedSchool). Exploring the optimal method to deliver therapeutics for cardiac regeneration. https://t.co/Fvo0MXq1Iz

[Jacob Scherba @JCScherba]

Pretty amazing work by my fellow grad student Tianyu Wu in the @BursacLab in collaboration with @APLandstrom and @perelli_robin to treat cardiac arrhythmia with engineered sodium channels. @DukeEngineering @DukeMedSchool #heartdisease #HeartMonth

[Bursac Lab @BursacLab]

Gene Therapy for Heart Disease https://t.co/Tq50HFwy8L via @GENbio