JacksonLab

Studying cellular signalling and proteostasis in response to mitochondrial dysfunction.

[JacksonLab @CBJacksonLab]

🚨 New from our lab (est. 2020) — now published in Nature Communications!
🧬We uncover a surprising link between the v-ATPaseand mitochondrial function:
Mild v-ATPase inhibition restores cell fitness under mitochondrial mistranslation stress
https://t.co/9rWlgmGblB
(Thread ⬇️)

[JacksonLab @CBJacksonLab]

🔥This opens a path toward targeting v-ATPase with precision, with implications from cancer to mitochondrial disease.

[JacksonLab @CBJacksonLab]

🚨 New from our lab (est. 2020) — now published in Nature Communications!
🧬We uncover a surprising link between the v-ATPaseand mitochondrial function:
Mild v-ATPase inhibition restores cell fitness under mitochondrial mistranslation stress
https://t.co/9rWlgmGblB
(Thread ⬇️)

[JacksonLab @CBJacksonLab]

Mild v-ATPase inhibition boosts ΔΨm and restores cell fitness under mitochondrial mistranslation stress — even in patient-derived fibroblasts.
🔬A major effort led by Geoffray, revealing how cells deploy extra-organellar control to survive mitochondrial dysfunction.

[Ed Reznik @EdReznik]

Together with @mito_oncogene, today we report in Nature Genetics a peculiar + exciting discovery: positive selection of mutations to mitochondrial ribosomal RNA in cancer. Led by Sonia Boscenco, Jacqueline Tait-Mulder, and Minsoo Kim https://t.co/MP4lEOs6SN

[Anu Suomalainen Wartiovaara @AWartiovaara]

Local de novo synthesis of serine delays mitochondrial muscle disease progression. Tour de force work of Christopher Jackson and ⁦@marmyleva_ana⁩ Anastasiia Marmyleva. Congrats Anastasiia especially for your first 1st author paper! ⁦@ASW_lab⁩ https://t.co/XVGtNoxKJq

[Anastasiia Marmyleva @marmyleva_ana]

✨Excited to share our new paper in @CellReports! ✨We show how cells rely on self-made serine to protect themselves under mitochondrial stress. Huge thanks to my mentors @CBJacksonLab and @AWartiovaara 🙏

https://t.co/STGEsZd3zN

[Aleksandra Filipovska @FilipovskaLab]

Unique architectural features of mammalian mitochondrial protein synthesis
30-day free access to our new review at: https://t.co/Mbsbic4SfK
Thanks to all the authors for their insightful contributions and our editor for their kind invitation and guidance.

[Christopher Carroll @Carroll_C_J]

Please check out out our paper with @CBJacksonLab and @Solocanuck👇
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation https://t.co/y2oX1B0K8L
@GMonteuuis @KrysiaBroda @ElizabethPyman @_DiegoBalboa_ 1/7

[Cell @CellCellPress]

In the latest issue! Problem choice and decision trees in science and engineering https://t.co/2wopdehRba

[Matthias Mann Lab @labs_mann]

Our mapping of the cellular protein #interactome with unprecedented depth is now published @nature. Leaps in robust #proteomics and analytic workflows enabled us to perform over 4.000 pull-downs in yeast unraveling the social and structural aspects leveraging #alphafold multimer.

[MetaStem @MetaStem_Center]

Welcome to the Metabolism seminar on Friday, Oct 13th at 9-11 am, Haartman Institute Lecture Hall 2. Talks on nutrient transporters in cancer and mitochondrial quality control by @Rafabolism and @CBJacksonLab ☕️🍪at 8:30. Spread the word @STEMMProgram @HelsinkiUniMed @BIOTECH_UH

[JacksonLab @CBJacksonLab]

World Mitochondrial Disease Week https://t.co/RWywvNuyNY

[JacksonLab @CBJacksonLab]

in other words: 700 Million people worth of cells.

[JacksonLab @CBJacksonLab]

https://t.co/SEB2Hbtkc5

[JacksonLab @CBJacksonLab]

“… it is estimated, 50m tonnes of her cells have been produced.”

[JacksonLab @CBJacksonLab]

@coffee_lipe Beware of age-induced astigmatism.

[Nils-Göran Larsson @mitopinionated]

Our preprint show that knock-in mice with drastically reduced levels respirasomes have normal OXPHOS function and no obvious phenotypes! Very unexpected results indeed! Presented the story at EuroMit. Thanks all coauthors for a very nice collaboration!
https://t.co/xDlQrB0HVp

[Alice Ting @aliceyting]

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec.

We explore 4 intracellular and intercellular applications of TransitID:
- discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix)
- mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress
- discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery
- analysis of proteins that traffic intercellularly bw tumor cells & macrophages

Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor

https://t.co/yo4laOA14z

[JacksonLab @CBJacksonLab]

Interested in a postdoctoral project encompassing genome-wide CRISPR/Cas9 screening and mitochondrial metabolism? Let’s apply for a Marie Sklodowska-Curie Postdoctoral Fellowship. Deadline: 13.09.2023 #msca #postdoc #fellowship #funding

[JacksonLab @CBJacksonLab]

This position is now filled.

[JacksonLab @CBJacksonLab]

PhD position available in our group: project in genome-wide signalling and cell-type-specific susceptibility to mitochondrial translation defects. Please RT and get in touch https://t.co/g9obqbCnpQ @mitojobs