Chrysanthi Kagiou

PhD student @Winter lab | CeMM

[EFMC @EuroMedChem]

📄 EFMC Literature Spotlight

📌 Discover our July literature spotlight; “Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation” by Winter G.E et al.

🔗 Read more: https://t.co/WhuZ0URYhK

#efmcliteraturespotlight #medchem #chembio #naturepublishing

[Chrysanthi Kagiou @CKagiou]

Beautiful work, crucial for uncovering the mechanism of alkylamine degraders, helping the progress of our recently published work. Our complementary studies together with the new FBXO22-based PROTACs from Zhang lab (https://t.co/fCKAm772iI) have unclocked FBXO22 for TPD!

[Cheryl Arrowsmith @CherylArrowsmi1]

Published today, our fantastic collaboration with Lindsey James group, @BrianRaught, and Licht Lab.
Thanks to the talented David Nie and John Tabor!
https://t.co/fzyfVafF7W

[Chrysanthi Kagiou @CKagiou]

@danetteldaniels @doc_jlmeier These memes are amazing! I m only upset I did not think about them first. Haha

[CeMM @CeMM_News]

🔬 Targeted Protein Degradation: A new adapter molecule expands the therapeutic potential around the cell's waste disposal system, CeMM PI @georg_e_winter's team published a new study in @NatureComms : https://t.co/znDQvb6DYK
Read more ➡️ https://t.co/ieUc9EdyDg

[Chrysanthi Kagiou @CKagiou]

@SFB_TPDvienna @NatureComms Thank you!

[Chrysanthi Kagiou @CKagiou]

Delighted to see our paper out in @NatureComms! We uncovered that alkylamine-tethered molecules recruit FBXO22 for TPD, making it an exciting addition to the TPD toolbox. https://t.co/qt9JuAdxJy

[Chrysanthi Kagiou @CKagiou]

@KRHornberger @ollie_lh @danetteldaniels @doc_jlmeier Yes, we were surprised as well!

[Chrysanthi Kagiou @CKagiou]

@KRHornberger @danetteldaniels @doc_jlmeier It could be a possibility, but we tested up to PEG4 which was the longest of all the linkers we had used so far. And for both FKBP12 and the two other targets, NSD2 and XIAP, shorter linkers worked as well. In any case target-to-target optomization would be the way to go.

[Chrysanthi Kagiou @CKagiou]

@ElisaMHahn @NatureComms Thank you!!! 😊

[Chrysanthi Kagiou @CKagiou]

@mguarini1 @NatureComms Thank youuuu Maria! ☺️☺️

[Chrysanthi Kagiou @CKagiou]

Finally, shoutout to @CherylArrowsmi1
and James labs for orthogonally elucidating a shared mechanism for another alkylamine degrader targeting NSD2 that was very instructive for our own work. https://t.co/rnY8z3Q90a

[Chrysanthi Kagiou @CKagiou]

Grateful to everyone at @CeMM_News that contributed, @FOffensperger, @CisnerosTrigo, @_matthias_h, @nataliescholes3 and Gary Tin in Winter lab, our in-house metabolomics facility team and @ChHorstmann from Grebien lab at CCRI.

[Chrysanthi Kagiou @CKagiou]

This was the result of an amazing team effort! Special thanks to @jakobfarnung and @JoannaLiwocha from the Schulman lab for the biochemistry expertise, and Kevin Dong, Ka Yang and Joao Paulo from Gygi lab for the proteomics support.

[Chrysanthi Kagiou @CKagiou]

Big thanks to my PI @georg_e_winter, and our collaborators @GygiLab, Brenda Schulman lab and @johannes_zuber lab for the invaluable support and expertise!

[Chrysanthi Kagiou @CKagiou]

@danetteldaniels @KRHornberger @doc_jlmeier Thank you! Haha, would be glad to discuss that list

[Chrysanthi Kagiou @CKagiou]

@georg_e_winter @WomenInTPD Thank you! Not degrading BRD4 makes it even more interesting to understand what FBXO22 could/could not degrade and why.

[Sdelci Lab @SdelciL]

We are very excited to share our story published in @MolSystBiol in collaboration with the Loizou Lab @LoizouJoanna, describing the role of PRDX1 as a nuclear-imported antioxidant enzyme for ROS scavenging after DNA-damage 🎉🎉🎉.
https://t.co/AFHLej32b9

[Marko Cigler @MarkoCigler]

Thrilled for our Orpinolide story to see the light of day! Huge thanks to the @georg_e_winter lab, Waldmann lab, @laraialab and everyone that contributed @HanaImrichova, @FabianFrommelt, @Laura_dta, Andrea, @CKagiou, Thomas, @CrisMayorRuiz, @gsf_lab and Sonja Sievers!
🧵👇