Cédric Chaveroux

ribosomal stress, stress signaling, cell plasticity.

[CNRS 🌍 @CNRS]

#Communiqué 🗞️ Reprise des essais cliniques aux États-Unis pour AGuIX, une technologie alliant imagerie et thérapie, imaginée pour améliorer l’efficacité de la radiothérapie sur certains cancers particulièrement difficiles à traiter.

👉 https://t.co/UDlJweR1qL

[CNRS Biologie @CNRSbiologie]

#ResultatScientifique🔎| Des scientifiques ont découvert que la protéine eIF5A, activée par hypusination, agit comme un "chef d’orchestre" et contrôle la progression du cancer de la prostate

✍️ @frederic_bost
📕 @NatureComms
▶️ https://t.co/aJ2JvSx9Yi

👉 https://t.co/TafXQUFl5J

[Jean-Ehrland Ricci @jer_06200]

Building on our Cell Met 2019 study, we show why some DLBCL patients relapse after L-asparaginase: metabolic rewiring drives DNA damage and PARP1/2 dependence. Targeting this with olaparib exploits resistance and enhances killing.
Kudos to @ChicheJohanna

https://t.co/jY2mqT0xGb

[Holger W. Auner @auner_lab_CH]

A novel potent and selective GCN2 inhibitor, APL-4098, has anti-leukemic activity through dysregulation of mitochondrial function https://t.co/xXW0RK0hCp

[Emiliano Ricci @emi_aeruginosa]

Our latest work describing how viral infections drive functional remodeling of ribosome-associated factors is out as a preprint! https://t.co/AEVMWl1cNx

[Cédric Chaveroux @C_Chaveroux]

Glad to share our latest review written with Dr @AltintasDogus , Marina Cerqua and Pr Paolo Comoglio on the "The Janus framework of the integrated stress response: from homeostasis to maladaptation"

https://t.co/SRSXjsM8wY

[Cédric Chaveroux @C_Chaveroux]

Role of the Gcn2 pathway in CAR-T cells
https://t.co/XcctzqOuRA

[Cris Muñoz-Pinedo & Ernest Nadal - PRETT lab @apoptosislab]

Why is the UPR activated upon glucose deprivation? a reviewer asked.
Why is IRE1 activated when glucose is low? a committee member for Mabel Cruz's PhD asked.

Mabel was surprised about the questions (is this not widely known?)
So we wrote a review about it with Eric Chevet.

[Cédric Chaveroux @C_Chaveroux]

Today we were pleased to welcome @AltintasDogus, who presented his latest work on the role of ISR-mediated translational reprogramming. Thank you Dogus for a very informative presentation and discussion. Interested, see https://t.co/drrGizbnE9

[Emiliano Ricci @emi_aeruginosa]

Our collaborative work with Vincent Vanoosthuyse's group, describing the use of virus-like particles to deliver ready-made RNaseH into cells and study RNA/DNA hybrids is out!
https://t.co/QOyuisflDl

[Cédric Chaveroux @C_Chaveroux]

Congratulations to @auner_lab_CH 👏👏👏for this new paper on GCN2-dependent but ISR-independent translation control mechanisms. And so many insights behind these remarkable results....

https://t.co/yEK6ImJzL7

[Jean-Ehrland Ricci @jer_06200]

Here I discuss the link between metabolism and immunosurveillance and how to exploit this link to improve treatment. I hope you find it interesting and useful. 🤗
Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets: Cell Reports https://t.co/aR0TgAfZmq

[Cédric Chaveroux @C_Chaveroux]

https://t.co/BqYndqD8V8

[Cédric Chaveroux @C_Chaveroux]

Mbf1 is required for optimal GCN2 activation. Great work from Drs R. Green and HS Zaher.

https://t.co/BFayi1agxd

[Cédric Chaveroux @C_Chaveroux]

Thanks to @FredericPerros for highlighting the need for human-relevant preclinical models in PVOD translational research—a challenge in many chronic diseases..

Bridging the species divide: The limits of rat models in capturing human PVOD mechanisms. https://t.co/8EW7vBphZR

[Cédric Chaveroux @C_Chaveroux]

Great study from Maragkakis lab.
https://t.co/LcyKkZfcMI

[Cédric Chaveroux @C_Chaveroux]

Our work demonstrating that GCN2 plays a dual role in controlling ribosome biogenesis in both proliferative and stressed contexts, is out. Original data but also novel questions to address regarding this fundamental pathway....Thanks to all participants.

[Molecular Oncology @MolOncology]

The role of GCN2 in controlling ribosome biogenesis in colon cancer #CancerResearch #RibosomeBiogenesis #FEBS #MolOnc
Read More: https://t.co/USCqYKG90S

[Molecular Oncology @MolOncology]

The role of GCN2 in controlling ribosome biogenesis in colon cancer #CancerResearch #RibosomeBiogenesis #FEBS #MolOnc
Read More: https://t.co/USCqYKG90S

[Cédric Chaveroux @C_Chaveroux]

https://t.co/e7RWp1AGLh

[CNRS 🌍 @CNRS]

#PodcastCNRS 🎧 Et si, à la place d'une injection 💉, les futurs #vaccins pouvaient fondre sous la langue ? Explication avec Claire Monge, biologiste CNRS, dans ce nouvel épisode de "Qu’est-ce que tu cherches ?"

👉 https://t.co/gJvKfQFfdM