Jamie Calacanis

Building the Future - Come Join!

@TWistartups & @LAUNCH

The #1 Startup Podcast in the World
Hosted by @Jason (host of All-In)
DMs open

[This Week in Startups @twistartups]

Want to come work with @Jason?

If you're highly motivated and passionate about tech, AI, and startups, our venture firm @LAUNCH and media division @twistartups have 14+ roles open!

Here's the full list 👇

[LAUNCH @LAUNCH]

Founder University Japan is coming BACK to Tokyo January 2027, and applications are OPEN 🇯🇵

[LAUNCH @LAUNCH]

10 startups. One week of back-to-back pitches & company visits.

We took our latest Founder University Japan batch on a Road Show... and they delivered. 🤝 🇯🇵

[This Week in AI @ThisWeeknAI]

Sam Altman’s AI predictions rely on a vision for “recursive self improvement” that does not yet exist, at least not publicly.

On TWiAI 36, the panel considers whether or not one frontier lab really could run away with the entire AI game, or if Altman’s “3 pathways forward for AI” prediction rests on a faulty premise?

Are the major labs talking about regulation so much because they’ve seen what kinds of models are coming next? Or just because regulation is good for whoever gets out to an early lead?

Expert panelists Jaleh Rezaei (Mutiny) and Alex Cheema (EXO Labs) join Jason and Lon for a brand-new This Week in AI.

@jason, @jalehr, @alexocheema, @lons, @mutinycorp, @exolabs

0:00 Cold Open / Show Intro
0:58 PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://t.co/rxqKyhAWuO
2:56 How much hardware it takes to run local AI models
4:32 DHS orders DeepSeek out of federal systems
5:53 Why enterprise clients are uneasy about Chinese models
9:47 Could an open-source model "phone home" to Beijing?
14:10 Why enterprises are much more price sensitive about AI tools
16:39 Are Sam Altman's AI endgame theories "deranged"?
25:45 Why the major labs want more regulations
26:28 The ElevenLabs Archer controversy continues
34:30 Who actually owns the rights to your voice?
45:17 "Substack for AI Models"
46:20 China needs more chips than Nvidia can make
52:40 Are enterprises running more local models?

🎥 Watch the full episode here 👇

[LAUNCH @LAUNCH]

And that’s a wrap on two full days of Startup Tuneup! 🚀

Here’s what went down on Friday afternoon 👇

[This Week in Startups @twistartups]

We’re going LIVE in 15 minutes with @shishirmehrotra, CEO of @Superhuman!

Tune in at 11 AM Central. Live links to watch in comments.

[LAUNCH @LAUNCH]

Our morning lineup of Startup Tuneup was 🔥

Here’s what went down 👇

[Lon Harris @Lons]

Want to check out the new Substack I'm building every day? For FREE?

[LAUNCH @LAUNCH]

A great adventure in Osaka! 🇯🇵

Last week, @Jason hosted @twistartups LIVE! w/

🫡 Yuki Shirato of @Techstars Japan +

💪 11 founders pitching for candid feedback

[Zach Spanke @ZSpanke]

Come work with me!

@LAUNCH and @Jason have open roles in Austin, Calgary, Saudi Arabia, and Japan. If you or someone you know could be a fit, please spread the word.

Open roles include:
- Programs Analyst
- Podcast & Video Editor
- Account Executive

https://t.co/VUOjaNx5KM

[@jason @Jason]

Excited to invest $25,000 in the winner of the @Qloo hackathon on @devpost!

[This Week in Startups @twistartups]

Video editors, wanna come work with @Jason on @twistartups?

We're hiring a podcast video editor to help us expand our content engine our venture firm, @LAUNCH. This role will edit short-form content for TikTok, X, Instagram, LinkedIn, and YouTube Shorts.

If you're a highly driven video editor, fascinated with tech, AI, and venture capital, and always trying to up your editing game with the latest AI trends, this position could be a fit.

Apply at https://t.co/Vul7nnim9z

[This Week in AI @ThisWeeknAI]

Amazon just blocked Meta's Muse agent, while Shopify handed it Shop Pay… why some legacy systems are resisting AI Assistant Mania.

On TWiAI 32, Richard Socher of Recursive, Guy Podjarny of Tessl, and Jake Loosararian of Gecko Robotics join Jason and Lon to discuss who wins when AI agents do the shopping.

PLUS OpenAI claims 100+ solved math problems on top of Navier-Stokes. Should they just pay the world's top 50 mathematicians $100 million each in stock and call it a day?

@jason @guypod @RichardSocher @jakeloosy

0:00 OpenAI claims 100+ solved math problems after Navier-Stokes
0:41 Welcome back to This Week in AI
1:04 Meet the guests: Guy Pigeon, Richard Socher, and Jake Lucier
2:54 Shopify and Meta team up so Muse can check out with Shop Pay
6:19 Why Amazon blocked Muse: ads, habit, and owning the front door
15:13 Do coupons and ads survive one-shot agent shopping?
18:04 OpenAI's internal model resolves 100+ longstanding math problems
26:07 Jason's pitch: pay the top 50 mathematicians $100M each
34:29 Why scientists should be as famous as NBA players
37:41 Anthropic's biology wet lab: can we trust it?
40:59 Why biology is the field AI will transform most
54:22 AI's trust problem and the wealth gap
57:29 The AI Tax and Work Protection Act
1:01:29 Will AI unemployment show up in the data?
1:11:47 TypeSafe AI's Jev: fast, calibrated decisions for software

🎥 Watch the full episode here 👇

[This Week in AI @ThisWeeknAI]

AI agents are about to skip the ads and the apps, and Travis Kalanick with Atoms is set up to win.

"The question is, is Travis going to disrupt [blank]? Default answer: YES."

@Jason

[This Week in AI @ThisWeeknAI]

Mathematicians are calling to slow down AI solving problems.

“I could not imagine biologists or medical researchers say don’t cure these diseases.”

@RichardSocher

[LAUNCH @LAUNCH]

If you want to build a great business in MENA, come to Riyadh in November.

Online with in-person sessions at Sanabil Hub.

https://t.co/dLkwfqCEJ4

[LAUNCH @LAUNCH]

🚀 Introducing LA37, the newest cohort in the LAUNCH Accelerator!

8 startups. 14 weeks. 1 mission: grow fast & raise capital.

Here’s who’s in 👇

[@jason @Jason]

Selling https://t.co/3OLtinXvXi and https://t.co/l427tBQFbh

Hoping an amazing startup can use these

Need to sell by November 1st

[This Week in AI @ThisWeeknAI]

HA! Who made this team?

[This Week in AI @ThisWeeknAI]

Dwarkesh's 'agent civilizations' blog post has divided the internet. Is this a helpful and methodical look behind the curtain at the OpenAI/Hugging Face breach? Or is this more of a hysterical AI Doomerism that will ultimately be used to make the case for banning data centers? Or BOTH? Plus, an electric plane that only needs $5 to fill up its battery, why rich founders should pick up a side quest, and the Bittensor subnet that's more effective than Fable 5 at sniffing out vulnerabilities."

0:00 Guest introductions
2:58 OpenClaw 2.0
5:11 "Agents ARE AI"
7:27 Billy: OpenClaw is still too technical for business users
9:00 Slack Code, and collaborative prompting
10:40 Multi-agent orchestration and Stripe's "minions"
14:13 Slack's moat, switching costs, and the Salesforce rebound
15:11 Jason's "Oracle": a heads-up display for the whole company
18:42 The Hugging Face breach: who's responsible when agents go rogue?
19:42 Perplexity launches Hybrid Compute — local models on your Mac
21:39 Why unmetered local tokens change corporate behavior
26:57 Gatik's Autonomous Vehicle AI Stack
32:22 Jason's Tesla FSD stories
34:05 Are AV companies being pushed to move too fast?
41:38 Trucking is a "have to have," robotaxis are a "nice to have"
42:36 Jason's fix: a safety driver for the first million rides
46:50 Why physical AI's adoption curve runs in decades
52:21 Anthropic's Model Hardware Standard (MHS), explained
1:06:27 How Jason got onion rings on the menu at Buck's of Woodside
1:09:05 AI detectors under fire: Pangram, MIT, and the handwritten diary
1:15:20 Why AI is "very mid" at writing (it learned from the average)
1:17:11 The Orin Kerr test: Pangram catches Claude writing as Kerr
1:28:35 Micro Duck and designing robots with Claude
1:29:42 Phil Kaplan's $14 custom circuit boards

🎥 Watch the full episode here 👇