Cameron McAlpine

Brain-body circuits in sleep, heart, and brain disorders
@IcahnMountSinai @SinaiHeartBlood @SinaiBrain @SinaiImmunol

[Cameron McAlpine @cam_phd]

We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis.

https://t.co/pzksoeQ9xG

[Cameron McAlpine @cam_phd]

Check out our review on modeling the exposome in murine cardiovascular disease! We need to expand holistic whole organism models to study lifestyle and environmental impacts on health to identify evolutionarily selected inter-organ mechanisms that can be therapeutically harnessed

[Matthias Nahrendorf @MatthiasNahrend]

Modeling the Exposome in Murine Cardiovascular Disease | JACC: Basic to Translational Science https://t.co/ZHWelGgjnw

[Eric Topol @EricTopol]

Of the major age-related diseases (cardiovascular, cancer, neurodegenerative) heart is the most preventable with lifestyle factors and medications.
It's about to become far more preventable!
@Drroxmehran and I teamed up for this @JACCJournals perspective
A "once-in-a-generation opportunity"
https://t.co/2KifJd2mfF

[Nancy Gillis 🆖☮️ @nancykgillis]

Officially published @jclinicalinvest - Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes @MoffittNews

🚨 It's not just whether clonal hematopoiesis (CH) is present - it's how it evolves that matters.🚨

https://t.co/L3AW8hkbgK

[Miriam Merad, MD, PhD @MiriamMerad]

Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) https://t.co/H8awCDz0HM

[Sasha Gusev @SashaGusevPosts]

Thought-provoking paper on interactions between genetic risk and exposures/behaviors:

https://t.co/mxmxQ3fPXG

[Cameron McAlpine @cam_phd]

My lab is expanding and I am looking for postdocs to join our team! If you are driven to pursue impactful science, have an interest in neuro-cardio-immunology, and want to live in vibrant NYC (with subsidized housing), please reach out!

https://t.co/gDrrhKKGdA

[Nature Reviews Cardiology @NatRevCardiol]

New online! Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis https://t.co/W5GEKZvNHx

[Cameron McAlpine @cam_phd]

We are happy to share another paper from the lab! Led by Lena Gaebel, using unconditioned cell transplant and congenic tracking, we show that Tet2 or Jack2 clonal hematopoiesis do not modify murine tauopathy.
https://t.co/7lZTGmpBRn

[nature @Nature]

Nature research paper: Mutation-dependent responses to sleep and exercise in clonal haematopoiesis

https://t.co/H0GPw22rRi

[Cameron McAlpine @cam_phd]

@jonykipnis @EpelmanLab Thank you, Jony!

[Cameron McAlpine @cam_phd]

We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis.

https://t.co/pzksoeQ9xG

[Cameron McAlpine @cam_phd]

@Zihai Yup! We can learn so much from conserved evolved behaviors that maintain our health, including new and better therapeutics.

[Michael Honigberg, MD, MPP @mchonig]

Delighted to contribute to this story now in @Nature led by T. Gerhardt & @cam_phd -

In humans & 🐭, exercise and 🛌 showed mutation-specific effects on clonal hematopoiesis, selectively reprogramming mutant cells toward less inflammatory states.

https://t.co/GmVkNSNdYP

[Friedman Brain Institute @SinaiBrain]

OUT NOW | PRESS RELEASE

In NEW STUDY, @IcahnMountSinai researchers Teresa Gerhardt, @cam_phd, et al. discovered that moderate-to-vigorous physical activity associated w/ reduced incidence of gene-specific CH & fewer mutant cells in blood. PRESS RELEASE👉 https://t.co/OPN9bnp6Wi

[Eric Topol @EricTopol]

Blood stem cell mutation clones (CHIP) occur frequently with advanced age and portend risk of cardiovascular disease and cancer. A new report @Nature today tells us about suppression of CHIP by sleep health and exercise in the experimental model and people
Data below for exercise, seen in both women and men
https://t.co/ZIEJWEkRsX

[Pradeep Natarajan @pnatarajanmd]

Delighted to participate in this paper spearheaded by @cam_phd with key human genetics contributions from @mchonig lab!
@broadinstitute @MGBResearchNews @harvardmed

[Cameron McAlpine @cam_phd]

@pnatarajanmd @mchonig @broadinstitute @MGBResearchNews @harvardmed It was a pleasure collaborating with you @pnatarajanmd and @mchonig!

[Cameron McAlpine @cam_phd]

@EricTopol @Nature Thank you for highlighting our work @EricTopol!

[Cameron McAlpine @cam_phd]

Healthy behaviors also restrict the inflammatory phenotype of CH mutant vascular macrophages through novel brain-body mechanisms to reduce atherosclerotic burden, independent of peripheral clone dynamics.

[Cameron McAlpine @cam_phd]

Combining human cohort data with murine models harboring mutations in Jak2, Tet2, Tp53, and Dnmt3a, we find that sleep and exercise attenuate the clonal trajectories of Jak2 and Tet2 CH by selectively reprogramming mutant hematopoietic progenitor cells.