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The Cambronne Lab has recently received a High Impact/High Risk Research Award Grant for our work on Targeting Mitochondrial NAD+ in Leukemia!
A big thank you to the Cancer Prevention and Research Institute of Texas!! @CPRITTexas
(7/8) The Cambronne Lab researches metabolism biology with molecules, namely NAD+. Vitamin Bs like nicotinamide, with help from NAMPT & NMNAT, synthesize NAD+ in the salvage pathway. William’s work isolated Vitamin Bs, enabling us to continue researching metabolism.
Also watch for studies on SLC25A51/MCART1 from the Sabatini lab, led by Nora Kory https://t.co/uWRnOSAhBe… and the Superti-Furga lab, led by Enrico Girardi https://t.co/mcZqqYQ7XS!
The really nice aspect of seeing these papers independently tackle the problem from such different directions means that the supporting evidence for the central discovery is now very, very strong. A big advance for our basic understanding of mitochondrial NAD+ metabolism!
Thread (1/3): Best Science = Collaborative Science.
We are pleased to share our latest work demonstrating NAD+ uptake in mammalian mitochondria by SLC25A51 transport. @nature@CambronneLab@BaurLab https://t.co/eikX1MJLm1
(3/3) Measurements of free mitochondrial NAD+ in live cells; demonstration with recombinant system of direct transport activity in vitro; kinetic rate calculations; beautiful 3D reconstructions @EllerJared@MuJie_Lu@PaulOliphint