Suleyman Can Akerman

Postdoctoral Fellow @johnshopkins, Rothstein lab, studying neurodegeneration.
Previously: McGill, ETH Zurich, Penn State

[Suleyman Can Akerman @CanAkerman]

LASER couples damage sensing to ESCRT assembly for lysosome repair
https://t.co/50XciQXpNY

[Suleyman Can Akerman @CanAkerman]

Universal transcriptomic hallmarks of mammalian ageing and mortality https://t.co/aQiIpM55R9

[Suleyman Can Akerman @CanAkerman]

In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology https://t.co/WbYi3Xa1oL

[Suleyman Can Akerman @CanAkerman]

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice https://t.co/BcTmC8Sh0y

[Suleyman Can Akerman @CanAkerman]

Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation
https://t.co/3TbU8SOIvM

[Suleyman Can Akerman @CanAkerman]

Tauopathy primes co-filament assembly and dysfunction of TDP-43
https://t.co/AFqkq49KEj

[Suleyman Can Akerman @CanAkerman]

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology https://t.co/np8gU7uumt

[Suleyman Can Akerman @CanAkerman]

Local Organization of Biological Membranes Modulates Tau–Lipid Interactions and Fibril formation
https://t.co/V0ArHXtgdk

[Suleyman Can Akerman @CanAkerman]

Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification
https://t.co/Mq7XOnU8mP

[Suleyman Can Akerman @CanAkerman]

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation
https://t.co/BGd3wKab1v

[Suleyman Can Akerman @CanAkerman]

Vascular burden attenuates the TDP-43-TMEM106B pathological relationship in neurodegenerative disease with and without Alzheimer disease neuropathological change
https://t.co/eJYnBKyAFP

[Suleyman Can Akerman @CanAkerman]

MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer’s disease and Down syndrome
https://t.co/Osz3xOGTLE

[Suleyman Can Akerman @CanAkerman]

Neuropathological analysis of an ALS patient carrying a SOD1 missense variant and a C9orf72 repeat expansion
https://t.co/vlu5Gb113w

[Suleyman Can Akerman @CanAkerman]

GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy
https://t.co/yXyVWc5y9P

[Suleyman Can Akerman @CanAkerman]

TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain
https://t.co/AnPDdnDpsk

[Suleyman Can Akerman @CanAkerman]

An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration https://t.co/U9kb899p5j

[Suleyman Can Akerman @CanAkerman]

Autophagosome-targeting single-domain antibody clears tau in patient-derived neurons and improves motor function in tauopathy mice https://t.co/K9xGoW05Et

[Suleyman Can Akerman @CanAkerman]

Proteomic profiling of brain organoids and extracellular vesicles identifies early Alzheimer's disease biomarkers and drug response heterogeneity
https://t.co/5W6lE8cGuo

[Suleyman Can Akerman @CanAkerman]

RPL38 controls 60S ribosomal subunit homeostasis to regulate start-codon stringency and frame selection during C9ORF72 RAN translation
https://t.co/wN3007QTzX

[Suleyman Can Akerman @CanAkerman]

Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner
https://t.co/yBIhK3AkKG