Suleyman Can Akerman

Postdoctoral Fellow @johnshopkins, Rothstein lab, studying neurodegeneration.
Previously: McGill, ETH Zurich, Penn State

[Suleyman Can Akerman @CanAkerman]

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue
https://t.co/QcOzif5q7K

[Suleyman Can Akerman @CanAkerman]

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue
https://t.co/QcOzif4Sic

[ShorterLab @ShorterLab]

Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue: https://t.co/LsSaoKsa4m

[John Lukens @LukensJohnR]

The sphingosine-1-phosphate receptor functional antagonist fingolimod exacerbates neuroinflammation and tau pathology in a mouse model of tauopathy https://t.co/rId0uNffEF

[Suleyman Can Akerman @CanAkerman]

Great to be part of #ALSNexus26 last week! I presented our work on modulating extracellular vesicles to inhibit dipeptide repeat propagation in C9-ALS, both in the Emerging Science session and as a poster.

Great discussions across the ALS community. #ALS

[Suleyman Can Akerman @CanAkerman]

Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer’s Disease Mouse Model
https://t.co/bN15JLhIef

[Suleyman Can Akerman @CanAkerman]

Distinct brain extracellular vesicle microRNA
profiles differ in frontotemporal dementia and
Alzheimer’s disease
https://t.co/LaDRoC2DVd

[Suleyman Can Akerman @CanAkerman]

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation
https://t.co/GB3hKBwW0F

[Suleyman Can Akerman @CanAkerman]

TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain
https://t.co/hgU8vJMQKM

[Suleyman Can Akerman @CanAkerman]

The UNC13A cryptic exon associateswith cognitive impairment in Alzheimer’sdisease
https://t.co/NYyHwQCtxb

[Suleyman Can Akerman @CanAkerman]

Multi-omics of C9orf72 spinal cord organoids reveal convergent molecular signatures and targets
https://t.co/dmmuCfjPDQ

[Suleyman Can Akerman @CanAkerman]

NAT10 inhibition corrects nuclear defects in tau mutant human neurons and extends lifespan in a Drosophila tauopathy model
https://t.co/KlaFUVEnMN

[Suleyman Can Akerman @CanAkerman]

TBC1D9 and TBC1D9B are ARL8 effectors that modulate exosome secretion through a RAB11A–exocyst pathway
https://t.co/be0IOBTu8T

[Suleyman Can Akerman @CanAkerman]

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease
https://t.co/PylabFEnYr

[Suleyman Can Akerman @CanAkerman]

SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain
https://t.co/Z0ImKmcbaM

[Suleyman Can Akerman @CanAkerman]

Cell-type signatures of Alzheimer’s disease shared across population groups
https://t.co/1GFbe9wdmY

[Charlotte Fare @charlotte_fare]

Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and Behavior https://t.co/e87GdfYzvq

[Suleyman Can Akerman @CanAkerman]

A new study profiled tau inside human brain-derived vesicles: the PHF6 (VQIVYK) motif is the seeding-compentent cargo. Blocking PHF6 could be a way to stop tau pathology in its tracks.
https://t.co/aqi4RzC25G

[Suleyman Can Akerman @CanAkerman]

Intersting preprint: blocking VPS4a could keep TDP-43 out of exosomes without stopping exosome production. That would suggest that one might be able to block the neuron-to-neuron spread of pathology without shutting down normal vesicle trafficking.
https://t.co/6fQaRdznCo

[John Lukens @LukensJohnR]

Injury-induced tau pathology promotes aggressive behavior in Drosophila without neurodegeneration | PNAS https://t.co/ep6KXNbdpk