Rothstein Lab

Dr. Jeffrey Rothstein is a professor of neurology and neuroscience @HopkinsMedicine and is the founding director of @packardcenter. (trainee run)

[Suleyman Can Akerman @CanAkerman]

Great to be part of #ALSNexus26 last week! I presented our work on modulating extracellular vesicles to inhibit dipeptide repeat propagation in C9-ALS, both in the Emerging Science session and as a poster.

Great discussions across the ALS community. #ALS

[Rothstein Lab @Rothstein_Lab]

TDP-43-related cryptic splicing reflects pathological heterogeneity in amyotrophic lateral sclerosis
https://t.co/FsETeaFjjB

[Rothstein Lab @Rothstein_Lab]

TTBK1 Inhibitors Modulate TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of TDP-43 Proteinopathy
https://t.co/RtrOxV0OzJ

[Rothstein Lab @Rothstein_Lab]

EPHA2/CD44-directed trafficking enhances endosomal leakiness and antisense therapy delivery
https://t.co/P8Z7lOjL4E

[Suleyman Can Akerman @CanAkerman]

Multi-omics of C9orf72 spinal cord organoids reveal convergent molecular signatures and targets
https://t.co/dmmuCfjPDQ

[Rothstein Lab @Rothstein_Lab]

Impaired Motor Function in a Zebrafish Stathmin-2 Knockout Model
https://t.co/oNFfYTDytz

[ShorterLab @ShorterLab]

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease: https://t.co/pIRywpvTdW

[Rothstein Lab @Rothstein_Lab]

Astrocyte dysfunction distinguishes monozygotic twin C9orf72 expansion carriers discordant for amyotrophic lateral sclerosis
https://t.co/0qgtTTOBdC

[Rothstein Lab @Rothstein_Lab]

Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MS
https://t.co/rxLsKHlJqB

[Rothstein Lab @Rothstein_Lab]

Schwann Cell–Specific TDP-43 Rescue Improves Peripheral Nerve Myelin Pathology Without Altering Motor Behaviour in a Mouse Model of ALS
https://t.co/ihMAtgTwIO

[Suleyman Can Akerman @CanAkerman]

Intersting preprint: blocking VPS4a could keep TDP-43 out of exosomes without stopping exosome production. That would suggest that one might be able to block the neuron-to-neuron spread of pathology without shutting down normal vesicle trafficking.
https://t.co/6fQaRdznCo

[Rothstein Lab @Rothstein_Lab]

Therapeutic targeting of the conserved region within the low-complexity domain of TDP-43 is neuroprotective and extends survival in amyotrophic lateral sclerosis mice
https://t.co/ty8McYpF0u

[Rothstein Lab @Rothstein_Lab]

Striatal neuron dysfunction in C9ORF72-FTD/ALS is driven by AIS and potassium channel dysregulation
https://t.co/L5PeAuxymC

[Rothstein Lab @Rothstein_Lab]

STMN2 protein depletion via translation deficits and stress granules in amyotrophic lateral sclerosis
https://t.co/NAYxp0FgSN

[Rothstein Lab @Rothstein_Lab]

An open-label Phase 2a study of fasudil in amyotrophic lateral sclerosis: safety and exploratory endpoints
https://t.co/JsyZOMEUHO

[Suleyman Can Akerman @CanAkerman]

Mitochondria directly interact with the nuclear pore complex
https://t.co/TVdB7rrRW0

[Suleyman Can Akerman @CanAkerman]

Excited to have shared our work on Nucleoporin210 in a tauopathy model at the Northeast Nuclear Envelope 2026 meeting at Yale (https://t.co/wFIZhmRmDX).

Thank you to the organizers for putting together such a nice program, and grateful for all the feedback and discussion!

[Charlotte Fare @charlotte_fare]

TDP-43 self-assembly is regulated by its disordered NLS-region https://t.co/bOEyxFf5cZ

[Rothstein Lab @Rothstein_Lab]

Downregulation of miRNAs Accompanies Increased HERV-K (HML-2) Expression in Amyotrophic Lateral Sclerosis
https://t.co/nC9Cjm21zF

[Rothstein Lab @Rothstein_Lab]

Development and characterization of 3D spinal cord organoids to advance the study of amyotrophic lateral sclerosis
https://t.co/qvIt0DJQPe