Rothstein Lab

Dr. Jeffrey Rothstein is a professor of neurology and neuroscience @HopkinsMedicine and is the founding director of @packardcenter. (trainee run)

[Rothstein Lab @Rothstein_Lab]

Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis
https://t.co/hvOHVz5qPh

[Rothstein Lab @Rothstein_Lab]

Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification
https://t.co/32D3DMujLw

[Rothstein Lab @Rothstein_Lab]

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases
https://t.co/1J6nLSLjXd

[Rothstein Lab @Rothstein_Lab]

Cryptic Splicing in ALS: From Driving Disease Progression to Unlocking Novel Therapeutics
https://t.co/kt16KaxgQd

[Rothstein Lab @Rothstein_Lab]

Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq
https://t.co/eZ4RPEA49C

[ShorterLab @ShorterLab]

Astrocytes connect specific brain regions through plastic networks: https://t.co/toTRUOr53v

[ShorterLab @ShorterLab]

Rab27b: A Modulator of Lysosomal Function and Alpha-Synuclein Clearance in Parkinson's Disease https://t.co/vrDy40OqwO

[Suleyman Can Akerman @CanAkerman]

TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain
https://t.co/AnPDdnDpsk

[Rothstein Lab @Rothstein_Lab]

Aberrant SOD1 aggregates in skeletal muscle target fibers in amyotrophic lateral sclerosis
https://t.co/owU7OfLVCg

[Rothstein Lab @Rothstein_Lab]

Biochemical and Immunohistochemical Associations of TDP-43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer’s Disease
https://t.co/Wjdp6KaoxO

[Rothstein Lab @Rothstein_Lab]

TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosis
https://t.co/aamBHKOey5

[Rothstein Lab @Rothstein_Lab]

Decoding neurodegeneration one cell at a time
https://t.co/IvEcpk27kS

[Rothstein Lab @Rothstein_Lab]

Metabolic signatures of ferritin and TDP-43 co-pathology provide a mechanistic basis for stratified therapeutic approaches in ALS
https://t.co/Hr12jnVYXl

[Rothstein Lab @Rothstein_Lab]

C9orf72 poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia
https://t.co/ZRDRLBJyYh

[Rothstein Lab @Rothstein_Lab]

Exploratory assessment of phosphorylated TDP-43 immunoreactivity in minor salivary glands of patients with ALS
https://t.co/eCM6dnOymp

[Rothstein Lab @Rothstein_Lab]

Characterizing TDP-43 involvement in vascular dementia
https://t.co/2kyQn7CX1N

[Rothstein Lab @Rothstein_Lab]

Amisodin alleviates TDP-43-associated ALS pathology by inhibiting the trimeric SOD1
https://t.co/wavv1JX59x

[Rothstein Lab @Rothstein_Lab]

C9orf72-derived dipeptide repeat proteins poly-PR disrupt membrane excitability and synaptic function in cortical neurons
https://t.co/bfB0xjvL4w

[Rothstein Lab @Rothstein_Lab]

C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes
https://t.co/IpELgrBXqY

[Rothstein Lab @Rothstein_Lab]

Impaired nucleocytoplasmic transport in SOD1-mediated ALS https://t.co/AMlTRPNh8E