The Cancer Dependency Map

We construct systematic key datasets, analytical and visualization tools to accelerate precision cancer medicine #depmap
Our other account: @depmap.org

[The Cancer Dependency Map @CancerDepMap]

New DepMap Release!
⭐ 35 CRISPR screens
⭐ NEW data from our Pediatric Dependencies Accelerator Program (learn more at https://t.co/Zet00g2IIc)
⭐ First 281 WES -> WGS
⭐ New Resources page
📣 DepMap is now on dbGaP (phs003444.v1.p1)
Read our release notes for more info!

[Mass General Brigham Research @MGBResearchNews]

In a new study, researchers from @MGHCancerCenter and colleagues' 'cell line atlas' provides a crucial resource for developing therapies for biliary tract cancer. The study was published in @CD_AACR.

Read more: https://t.co/jrK1pkGGfI @getz_lab @DrFranVazquez
https://t.co/RbppThCbqB

[Broad Institute @broadinstitute]

A new cell line atlas of biliary tract cancers uncovers new subtypes and potential drug targets for better treatment of these deadly diseases. Learn more: https://t.co/CIubxKAVMp

@MGBResearchNews @targetcancer

[Muller Lab @Muller_Lab]

https://t.co/oSk95uGy3Z

@CancerDepMap - PRISM screens can work with ADCs, bystander effects non-withstanding.

[The Cancer Dependency Map @CancerDepMap]

🚨Exciting New Synthetic Lethal Target from #depmap!

[The Cancer Dependency Map @CancerDepMap]

🚨Exciting New Synthetic Lethal Target from #depmap!

[Broad Institute @broadinstitute]

Scientists have discovered a genetic vulnerability — found in 5 percent of adult cancers — that could be a promising drug target. https://t.co/rWb4QvVixd

[The Cancer Dependency Map @CancerDepMap]

📢 Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute)

Highly recommended!

Register here
https://t.co/ttlOUWEwKR

[The Cancer Dependency Map @CancerDepMap]

📢 Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute)

Highly recommended!

Register here
https://t.co/ttlOUWEwKR

[The Cancer Dependency Map @CancerDepMap]

DepMap keeps growing—and so does the portal!

To help navigate the portal, new in 24Q4 we’ve launched a new resource page 🚀! Check it out and share your feedback.

https://t.co/atsJUV7CQE

[The Cancer Dependency Map @CancerDepMap]

Thank you for the suggestion!

[Lindonlight Collective @Lindonlight]

@CancerDepMap Tip for further improvement: make HLA genotypes searchable for cell lines in DepMap.

Would help a lot for TCR targeting therapeutics development

[The Cancer Dependency Map @CancerDepMap]

DepMap keeps growing—and so does the portal!

To help navigate the portal, new in 24Q4 we’ve launched a new resource page 🚀! Check it out and share your feedback.

https://t.co/atsJUV7CQE

[The Cancer Dependency Map @CancerDepMap]

New DepMap Release!
⭐ 35 CRISPR screens
⭐ NEW data from our Pediatric Dependencies Accelerator Program (learn more at https://t.co/Zet00g2IIc)
⭐ First 281 WES -> WGS
⭐ New Resources page
📣 DepMap is now on dbGaP (phs003444.v1.p1)
Read our release notes for more info!

[Nature Reviews Cancer @NatureRevCancer]

NEW content online! The present and future of the Cancer Dependency Map https://t.co/8tB7pXPN9r

[The Cancer Dependency Map @CancerDepMap]

How do you use the DepMap Portal? 💻

As we enter the final year of our grant, we need your insights! Take this quick 2-question survey to help us understand what you like and what you'd like to see in the future. Your feedback is invaluable!  https://t.co/PievoUW2PV

[The Cancer Dependency Map @CancerDepMap]

@Muller_Lab @seattlechildren @Cellosaurus Thank you @Muller_Lab! @seattlechildren generously shared a panel of pediatric brain tumor cell lines with us. We are in the process of screening them as part of our pediatric depmap program #peddep

[The Roberts Lab @TheRobertsLab1]

We identified PHF6 as a critical #dependency for the survival of #SMARCB1-mutant cancers through #CRISPR screenings conducted in collaboration with @cancerdepmap.

[The Cancer Dependency Map @CancerDepMap]

🥳 The DepMap Portal Webinar is Today!

💻 Use the link below to join the Webinar at 12pm EST today. We look forward to seeing you there!

https://t.co/VuE0Dc0nsc

[The Cancer Dependency Map @CancerDepMap]

📢 DepMap is hosting a webinar!
Join members of the DepMap team on Thursday, Aug 1 starting at 12pm EST to learn more about the latest DepMap release and deep dive into Data Explorer 2.0. RSVP to let us know you're attending! https://t.co/UGb5hZo6X4

[The Cancer Dependency Map @CancerDepMap]

As always, the bi-annual DepMap Release datasets are available to download, and now organized in the “Current Release” section of the DataHub. All datasets can be found in the “All Data” section. You can also curate custom contexts in the “Custom Downloads” section.

[The Cancer Dependency Map @CancerDepMap]

Explore our new DataHub! The DepMap Downloads page is now a DataHub, where you can download files and find useful information about DepMap Release datasets. In the “Overview” section, you can learn how DepMap data is structured and how to map and cite DepMap Release data.

[The Cancer Dependency Map @CancerDepMap]

Data Explorer 2.0 provides greater capabilities for plotting and visualizing data. To get started, check out our tutorial, which can be found on the Data Explorer 2.0 landing page.

Keep an eye out for future posts about tutorials, upcoming webinars, and more!

[The Cancer Dependency Map @CancerDepMap]

🎉New DepMap data and tools available on the portal! We’re excited to release new Omics and CRISPR data to the DepMap portal, as well as a new portal tool, Data Explorer 2.0, and a new DataHub where you can learn more about DepMap’s data structure and how to map data files.