Carl June

[Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 @BLLPHD]

Heading to the @ISCTglobal Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts.

We’ve built an integrated platform designed to move programs from discovery into first-in-human studies with rigor, speed, and quality.
What differentiates this model is not a single capability, but the integration:
• cGMP Phase I manufacturing in 15 ISO 7 suites
• Process development and scale-up for complex cell therapies
• End-to-end QC analytics and FACT-aligned quality systems
• Advanced correlative science, including multiparameter flow, molecular assays, and spatial biology
• Deep experience translating across oncology and immune diseases

We are actively looking to partner with biotech, pharma, and academic groups in three areas:
• Manufacturing: early-phase and first-in-human CGT production
• Process development: improving robustness, scalability, and comparability
• Analytics and correlative studies: biomarker strategies that inform mechanism, response, and durability

If you are advancing a program and need a partner who understands both the science and the realities of clinical translation, we should connect to build the next generation of cell and gene therapy together. #celltherapy #genetherapy #innovation #immunotherapy

[Carl June @carlhjune]

@UgiUslu and @sophiacastelli from my lab published comprehensive review of CAR T combinations in Cancer Cell today: https://t.co/FJIEadTuOZ

[Ugur Uslu @UgiUslu]

Check out our commentary @Cancer_Cell where we summarized CAR T cell combination treatments currently in clinical development for both, hematological malignancies and solid tumors! With @MSofiaCastelli and @CarlHJune
https://t.co/dkbcfFMwiW

[Ugur Uslu @UgiUslu]

Check out our latest paper, published @NatureComms. We show that STING activation induces IL18 secretion and thereby enhances CAR T function. Great collaboration between @CarlHJune lab and James Chen @UTSWMedCenter.
@PennMedicine @PennMDForum @PennPPA
https://t.co/zkWtZxdoRw

[Carl June @carlhjune]

wonderful work from @sonia guedan, former post doc. From her lab in Barcelona,j ust published in Nature Communications https://t.co/TrEqgMc13k

[Carl June @carlhjune]

Anti-competitive practices of 10X genomics have forced Nanostring into chapter 11 restructuring. 10x has initiated litigation against not only Nanostring but also Vizgen, Curio Biosciences and Parse Biosciences. See below for more information:
(https://t.co/z6VevZQlbD)
(https://t.co/F5heI8tsrH)

[Carl June @carlhjune]

https://t.co/364PV7MAK7
My lab in Spotlight at 76ers historic game when Embiid scored 70 points and set a franchise record for the 76ers. @PennMedicine

[Philadelphia 76ers @sixers]

🩺 @PennMedicine spotlight:

last night we recognized Dr. Carl June, the Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania.

Dr. June is joined by members of the June Laboratory, which provides researchers with the tools they need to translate laboratory insights into safe and effective cancer therapies. The June Lab has many faculty researchers focused on developing ways to enhance the ability of the natural immune system to recognize and eliminate tumor cells.

[Carl June @carlhjune]

@DrMvandenBrink This is a wonderful opportunity

[Carl June @carlhjune]

@Majzner_Lab @DanaFarber @DFBC_PedCare Welcome to the best coast!

[Daniel Baker @daniel_baker_j]

Tons of promising work using CAR T cells beyond cancer. Already showing signs of efficacy in early clinical reports. Check out our review in @Nature of this rapidly evolving field!

W/ @AranyLab @BaurLab @jonepstein1 @carlhjune

https://t.co/QlDYO8nWvK

[Carl June @carlhjune]

thrilled that Bruce Levine to receive PMWC 2023 Pioneer Award. https://t.co/HljFgiQKI8

[Tanya Bondar @_TanyaBondar_]

What can happen when #CARTcell Therapy Meets #ClonalHematopoiesis? @CarlHJune puts multiple scenarios InFocus @BCD_AACR
https://t.co/gVJT7UWL0G

[Carl June @carlhjune]

CAR T in Costa Rica

[Carl June @carlhjune]

@GruppSteve @FDA Celebrating 10 years. We are so grateful for the brave patients who volunteered for CAR T at CHOP and PennMedicine

[Stephan Grupp MD PhD @GruppSteve]

10 years ago Emily Whitehead’s family got the news that she was cancer free. We wondered whether these #carTcells could keep her in remission and cure her disease without BMT. Now we know.

10 years from this transformative clinical experience, 5 years from @FDA approval.

[Carl June @carlhjune]

The June lab is excited to offer a postdoctoral position with a focus on T cell engineering and synthetic biology in the Center for Cellular Immunotherapies at the Perelman School of Medicine at the University of Pennsylvania.

[Carl June @carlhjune]

Penn Patients with Decade-Long Leukemia Remissions after CAR T Cell Therapy Reveals New Details About Persistence of Personalized “Living Drug” Cells. Delighted to announce our study in Nature today

[Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 @BLLPHD]

Was $NVS BELINDA #CARTCell #tcellrx vs SOC Phase III failure in #lymphoma due to manufacturing?? If 2% serum used in ex vivo media, acknowledged 2B inferior to 5% in #ASH21 poster 1768. 5% only used from end 2020 onwards. #lymsm #immunotherapy https://t.co/MkrTeJNb1W

[Carl June @carlhjune]

brave scientists against Texas

Bravo Tom Curran and Myles Brown:

Two members of the highest-level review board of the Cancer Prevention and Research Institute of Texas have submitted their resignations from the board of the state-funded institute.

[Carl June @carlhjune]

I've had it with gun violence. The husband of my 3rd cousin was shot and is now hemiplegic
in a senseless drive by shooting.

Yakima man hit in drive-by shooting while working in yard in Barge-Chestnut area | Crime And Courts | https://t.co/0f1kPxYcPI https://t.co/2I6pCCwul7