We're a research lab at Rockefeller University (NY) and Necker Hospital (Paris) studying human genetic and immunological determinants of infectious diseases.
1/ Spotlighting our former trainee @alexyema - a clinician-scientist specializing in IEI and cellular therapies @ UCL Great Ormond Street Institute of Child Health (GOSICH). She is also an Honorary Consultant in Paediatric Immunology at Great Ormond Street Hospital (GOSH), London
Our latest work on the role of STING in autoinflammation. STING proton channel activity influences Golgi transit & secretion of cytokines through ArfGAP2.
ArfGAP2 promotes STING proton channel activity, cytokine transit, & autoinflammation: Cell https://t.co/tXF2mWgqLB
Attending #FOCIS2026 in San Francisco? Join 📃 Late Breaking Abstract session on Wednesday, June 10, 4pm-6pm! JEM's Executive Editor Natalie Cain (@NatalieCainSci) will be chairing the session 👩🏫
🗓️ Be sure to add this session to your schedule!
@focisimmunology
New in @CellCellPress! 📣
This study, led by Université Paris Cité and Sorbonne Université collaborators supports a model in which a memory B cell response directed against type-I IFNs is established before severe #viral infection.
🔗 https://t.co/A8C9jXfxtm
Why do some people develop life-threatening viral disease, while others clear the same virus with only mild symptoms?
One answer is becoming clearer.
In some people, the first line of antiviral defense is already weakened before the virus arrives🧵
6/ Cycling has been an outlet since her time in NY and now it’s a platform for advocacy: @alexyema recently rode 800km from London to Glasgow with other paediatric professionals to campaign for cleaner air. She’s also passing her love for the outdoors on to her children.
1/ Spotlighting our former trainee @alexyema - a clinician-scientist specializing in IEI and cellular therapies @ UCL Great Ormond Street Institute of Child Health (GOSICH). She is also an Honorary Consultant in Paediatric Immunology at Great Ormond Street Hospital (GOSH), London
5/ Now as group leader at GOSICH, @alexyema advances understanding of human T-cell immunity by defining how genetic variation disrupts thymic development and T-lymphopoiesis in children with IEI. https://t.co/DOvJnX0PQJ
https://t.co/x33mR38Sxl
Hyper IgE syndrome is a rare and syndromic primary #immunodeficiency. Murray, Grimbacher et al. propose clinical management guidelines for this multisystem condition based on the experience and management of these patients in the last 25+ years. https://t.co/6bIhc4hFA9
#HowITreat
New human inborn error of immunity!
By identifying biallelic OSMR deficiency as a novel Primary Atopic Disorder, we uncover a previously unrecognized mechanism driving severe allergic disease and provide new insights into the biology of human atopy.
Last night I was delighted to deliver my inaugural lecture @imperialcollege, reflecting on my journey in science w friends & colleagues https://t.co/x9OWQP7yBD
Streamline your path to publication through JEM manuscript transfer. “The handling of the transfer by the JEM editors and staff was excellent.” — Tim Willinger, JEM author https://t.co/ozw62UibK9
📢Fresh pub, a rare case of GI-TB in 3mth old baby. We need more sensitive, non-sputum POC tests for paeds #tuberculosis#diagnosis ASAP! TB in young children can spread quicky with severe, life-threatening complications. Find the full paper here: https://t.co/VarI7wxf26