Casanova Lab

We're a research lab at Rockefeller University (NY) and Necker Hospital (Paris) studying human genetic and immunological determinants of infectious diseases.

[Casanova Lab @casanova_lab]

1/ Spotlighting our former trainee @alexyema - a clinician-scientist specializing in IEI and cellular therapies @ UCL Great Ormond Street Institute of Child Health (GOSICH). She is also an Honorary Consultant in Paediatric Immunology at Great Ormond Street Hospital (GOSH), London

[Miner Lab @miner_lab]

Our latest work on the role of STING in autoinflammation. STING proton channel activity influences Golgi transit & secretion of cytokines through ArfGAP2.

ArfGAP2 promotes STING proton channel activity, cytokine transit, & autoinflammation: Cell https://t.co/tXF2mWgqLB

[Journal of Experimental Medicine @JExpMed]

Attending #FOCIS2026 in San Francisco? Join 📃 Late Breaking Abstract session on Wednesday, June 10, 4pm-6pm! JEM's Executive Editor Natalie Cain (@NatalieCainSci) will be chairing the session 👩‍🏫

🗓️ Be sure to add this session to your schedule!
@focisimmunology

[Immunology of Infectious Disease News @infdisease_news]

New in @CellCellPress! 📣

This study, led by Université Paris Cité and Sorbonne Université collaborators supports a model in which a memory B cell response directed against type-I IFNs is established before severe #viral infection.

🔗 https://t.co/A8C9jXfxtm

[Zdenek Vrozina @ZdenekVrozina]

Why do some people develop life-threatening viral disease, while others clear the same virus with only mild symptoms?
One answer is becoming clearer.
In some people, the first line of antiviral defense is already weakened before the virus arrives🧵

[Cell @CellCellPress]

In the latest issue! Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections https://t.co/y30oKLvwj2

[Casanova Lab @casanova_lab]

How I Treat: STAT3 hyper IgE syndrome https://t.co/kmlNRsFUn2

[Casanova Lab @casanova_lab]

6/ Cycling has been an outlet since her time in NY and now it’s a platform for advocacy: @alexyema recently rode 800km from London to Glasgow with other paediatric professionals to campaign for cleaner air. She’s also passing her love for the outdoors on to her children.

[Casanova Lab @casanova_lab]

1/ Spotlighting our former trainee @alexyema - a clinician-scientist specializing in IEI and cellular therapies @ UCL Great Ormond Street Institute of Child Health (GOSICH). She is also an Honorary Consultant in Paediatric Immunology at Great Ormond Street Hospital (GOSH), London

[Casanova Lab @casanova_lab]

5/ Now as group leader at GOSICH, @alexyema advances understanding of human T-cell immunity by defining how genetic variation disrupts thymic development and T-lymphopoiesis in children with IEI. https://t.co/DOvJnX0PQJ
https://t.co/x33mR38Sxl

[Casanova Lab @casanova_lab]

@blepiro 👍

[Casanova Lab @casanova_lab]

A surprising and exciting observation !
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease https://t.co/BFzcoq1Tyo

[Journal of Human Immunity @jhumimmunity]

Hyper IgE syndrome is a rare and syndromic primary #immunodeficiency. Murray, Grimbacher et al. propose clinical management guidelines for this multisystem condition based on the experience and management of these patients in the last 25+ years. https://t.co/6bIhc4hFA9
#HowITreat

[Turvey lab @TurveyLab]

New human inborn error of immunity!
By identifying biallelic OSMR deficiency as a novel Primary Atopic Disorder, we uncover a previously unrecognized mechanism driving severe allergic disease and provide new insights into the biology of human atopy.

[Petter Brodin @BrodinPetter]

Last night I was delighted to deliver my inaugural lecture @imperialcollege, reflecting on my journey in science w friends & colleagues https://t.co/x9OWQP7yBD

[Journal of Human Immunity @jhumimmunity]

New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. https://t.co/2hdpZwogkP

#Immunology #Genetics #Atopy #IEIs

[Journal of Experimental Medicine @JExpMed]

Streamline your path to publication through JEM manuscript transfer. “The handling of the transfer by the JEM editors and staff was excellent.” — Tim Willinger, JEM author https://t.co/ozw62UibK9

[Jacquie Oliwa @JacquieOliwa]

📢Fresh pub, a rare case of GI-TB in 3mth old baby. We need more sensitive, non-sputum POC tests for paeds #tuberculosis #diagnosis ASAP! TB in young children can spread quicky with severe, life-threatening complications. Find the full paper here: https://t.co/VarI7wxf26