Riccardo Capecchi

MD, PhD. Clinical Immunologist/Internal Medicine. I did stuff with antibodies.
Tweet in eng/ita. In transito su e bsky

[Riccardo Capecchi @blepiro]

I think the time here is over.

Mastod0n was too elephantiac to be useful (dislocated servers work pretty bad for me).

I'll be Flying more frequently in a bluer Sky. Same nickname. I'll be digging the mug here from time to time for the feeds.

Thank you all (not you, Elon)

[Casanova Lab @casanova_lab]

How I Treat: STAT3 hyper IgE syndrome https://t.co/kmlNRsFUn2

[Massimo @Rainmaker1973]

Richard Feynman's Lectures on Physics are timeless: their main strength is in demonstrating how to reason about physics.

You may not know that all the lectures are completely online:

Vol 1: https://t.co/yDpyRViG61
Vol 2: https://t.co/oEctaDhy2X
Vol 3: https://t.co/eXS03nu9fE

[Dr. Thomas Ichim @exosome]

Nature paper.... "stem cells have memory" !!!

Read it before they take it down....heresy !!!

https://t.co/hFzGmGon0H

[Ryan Peterman @ryanlpeterman]

Avi Wigderson is the only person in history to have won both a Turing Award (computer science) and Abel Prize (math). I interviewed him all about his field. We discussed:

• His intuition on a proof of P vs NP
• Why we use SAT solvers for most NP problems
• Zero knowledge proofs and their impact
• Quantum computation and implications
• Math and computer science's relationship

Where to watch:
• YouTube: https://t.co/zViqAulFCo
• Spotify: https://t.co/iat08Xob17
• Apple Podcasts: https://t.co/jOYDGtGVnt
• Transcript: https://t.co/k4zS7yOhnw

Thank you to this episode's sponsors for supporting my work:
• WorkOS: makes your app Enterprise Ready with easy to use APIs to add SSO, SCIM, RBAC, and more in just a few lines of code, check them out at https://t.co/y8noBzFEem

Timestamps:

00:00 - Intro
01:08 - P vs NP
14:51 - What if you relaxed correctness
25:38 - Why NP complete problems are equivalent
30:33 - Space vs time complexity
43:06 - Why people use SAT solvers
45:53 - Randomness is a resource
55:48 - Randomness depends on computational power
01:21:20 - Zero knowledge proofs and their significance
01:38:30 - Quantum computation and why it matters
01:56:24 - Math vs computer science
02:08:16 - Major breakthroughs and his experience
02:12:31 - Advice for his younger self
02:14:48 - Outro

[Mark Lewis, MD, FASCO @marklewismd]

As many other oncologists will also attest, we were taught this was a dead end

It was, dogmatically, never going to work — kras was too much of a “greasy ball” to be targeted

And yet here we are, with truly meaningful survival curves👇

Inspiration on multiple levels #ASCO26

[Turing Post @TheTuringPost]

A must-read survey to refresh math and gen AI basics → The Little Book of Generative AI Foundations: An Intuitive Mathematical Primer

It shows a clear walkthrough of how gen AI learns to understand, model, and create complex data, covering:

- Latent algebra foundations: PCA, SVD, autoencoders
- Latent models: PPCA and VAEs
- VAEs: ELBO, inference, reparameterization
- Diffusion: the way from noise → denoising
- Score-based and continuous-time generative modelling
- Density models: flows, autoregression
- GANs and energy-based models beyond likelihoods

[Mark Lewis, MD, FASCO @marklewismd]

Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer

Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived

#ASCO26

[Parmita Mishra @parmita]

RAS finally getting drugged is one of the great stories in modern biology, and almost nobody outside oncology understands why it's such a big deal.

YOU'LL LEARN SOMETHING AWESOME TODAY.

i am going to keep this as understandable (and simple) as i can.

OPEN THE THREAD.

🧵

[Maurizio Scaltriti @ScaltritiLab]

In 20 anni di congressi ho assistito a due standing ovation. La prima per un farmaco che ho contribuito a sviluppare. La seconda adesso.

[Frank Nielsen @FrnkNlsn]

A road to information geometry:

top:
probability and math./comp. statistics

middle:
IG textbooks: from beginner's to advanced level, with its dedicated journal

bottom:
differential geometry: from Riemannian to symplectic/contact

[Riccardo Capecchi @blepiro]

@ProofofMaro AI using people

[Eric Topol @EricTopol]

There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
https://t.co/e04jqJMPw0

[nature @Nature]

Catalogue entries for more than 100 antibodies sold by the research services and supply company Thermo Fisher Scientific contain images that have apparently been manipulated, according to a pair of science sleuths.

https://t.co/5rUUgxceoE

[Riccardo Capecchi @blepiro]

@ProofofMaro I like your Beethoven obsession. Thank you

[Riccardo Capecchi @blepiro]

@arjunrajlab I am waiting for an Atlas of Atlases of Cell Atlases

[Arjun Raj @arjunrajlab]

Okay, I made an Atlas of Cell Atlases. Will post code later.

[Riccardo Capecchi @blepiro]

@arjunrajlab What are the dimensions

[Riccardo Capecchi @blepiro]

@casanova_lab Is it a new Primary Atopic Disorder?

[Casanova Lab @casanova_lab]

A surprising and exciting observation !
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease https://t.co/BFzcoq1Tyo

[Riccardo Capecchi @blepiro]

@ProofofMaro Also from people