Cathy Guo

[Mat Legut, PhD @MatLegut]

Really chuffed to share our latest work from Sanjana Lab out in @nature today (https://t.co/skHTGrKACw).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.

A thread...

[Orli Bahcall @obahcall]

Last call! Register TODAY for free @CellGenomics home delivery!

Breaking: Includes a truly inspiring commission from the brilliant mind (and hands) of @ATJCagan! 🙏😍🙏

#OpenScience #OpenAccess

[Cell Genomics @CellGenomics]

New! Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens
👉Resource open access, enables guide RNA design for custom RNA targets 👏
@nevillesanjana @CathyxGuo @jahanpehechanho @we_harm @alexmenman @nygenome @nyuniversity @nyugrossman

[Neville Sanjana @nevillesanjana]

Delighted to see this work from our lab is now published as the first-ever (!) article in @CellGenomics:
https://t.co/d5HVDbbYh9
https://t.co/G3tR7gKjOQ

Congrats to PhD student @CathyxGuo & many other lab members. Check out our previous tweetorial for an overview 👇

[Neville Sanjana @nevillesanjana]

Preprint alert! 🚨 New work from our group for transcriptome engineering in human cells — including in T cells & to target SARS-CoV-2 — using chemically-modified guides and Cas13 RNPs.

Postdocs @alexmenman & @we_harm led the work & here's a great summary from Alex:
👇👇👇

[John Morris @johnomix]

Delighted to share work from my postdoc, co-advised by @nevillesanjana and @tuuliel! It began with wanting to identify target genes for GWAS with CRISPR screens and single-cell seq. Brief look below, with shout-outs to my amazing co-authors!

Link: https://t.co/uPe3qVSspS

[Neville Sanjana @nevillesanjana]

New preprint from our group: “Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens” led by @CathyxGuo with big help from @we_harm, @alexmenman and #DanHaro.

https://t.co/eP41YWu1dt

[Cathy Guo @CathyxGuo]

“...as U.S.-China tensions worsen, I am left wondering what will come next.” And today the US government decide to ban WeChat. An app I used on a daily basis since I came to the US 8 years ago, the app that connect us to our friends and families back home. https://t.co/vJ72adqk00

[ACLU @ACLU]

Trump’s executive orders against WeChat and TikTok are yet another abuse of emergency powers under the broad guise of national security. They would violate the First Amendment rights of users in the US who use these apps to communicate with family, friends, or business contacts.

[Itai Yanai @ItaiYanai]

It is not well appreciated, but the truth is that one never really finishes to analyze a dataset. You just decide to stop and move on at some point, leaving some things undiscovered.

[David R. Liu @davidrliu]

Four labs (C. Gao, @JKeithJoung , D. Li, @yachielab) report combining cytosine base editors (which convert C•G to T•A) & adenine base editors (which convert A•T to G•C) into combination base editors that make both conversions, especially useful for screening & evolution. 1/2

[John Morris @johnomix]

Excited to share this preprint from the @nevillesanjana lab, led by myself and an ultratalented NYU undergrad, Jahan Rahman (@jahanpehechanho). We designed CRISPR prime editing reagents to target thousands of human pathogenic variants. Key findings 1st! 👇
https://t.co/eAdFz4XswA

[UCSC Genome Browser @GenomeBrowser]

We are pleased to announce new Hi-C heatmap tracks for hg19 and hg38. This is part of our ongoing support for researchers studying the structural components of gene regulation.
https://t.co/kGAqks8e1r

[Neville Sanjana @nevillesanjana]

A quantum computer solves a problem in 200s that not possible on the fastest supercomputers. 😮

[MIT Technology Review @techreview]

Neuralink unveiled a sewing machine-like robot that will implant ultrafine flexible electrodes deep into the brain. But what is it *for*? https://t.co/fKQFbGYkyo

[Neuralink @neuralink]

We've released a preprint with additional scientific detail on our devices for domain experts who want to know more. You can find it on bioArxiv: "An integrated brain-machine interface platform with thousands of channels" https://t.co/In7ZwOFIy9

[Neville Sanjana @nevillesanjana]

Huge progress in neuroscience. We are getting so much better at neural decoding. It has been more than a decade since the first visual decoding work so great to see this leap forward.

[Alba Meira @AlbaRMeira]

TARGET-seq is out in @MolecularCell ! Like moving from a blury photograph to a high resolution picture of #cancer we can now perform parallel mutation and whole transcriptome analysis from the same #SingleCell cell with extremely high resolution. https://t.co/K3FlHecjZa

[Konrad Karczewski @konradjk]

Using a stringent filtering tool called LOFTEE https://t.co/Nst1rwTKDi, we identify ~443K predicted loss-of-function variants, and 1,752 genes where we find at least one biallelic knockout individual (2/5).

[Nature Biotechnology @NatureBiotech]

Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides https://t.co/gsDuRDR3iy