Chayanika Banerjee

Simple girl in this complicated world
Research Scholar- Special Centre for Molecular Medicine
Cell and Molecular biologist
@vsicmb
Music lover🎶
Love yourself

[Prof. Feynman @ProfFeynman]

The first principle is that you must not fool yourself and you are the easiest person to fool.

[Immunity @ImmunityCP]

Online now: Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion https://t.co/0Qec398GVo

[오창명 @changmyung1981]

💀 Cell death is not determined by signaling alone—it is determined by metabolism.

A major Cell Metabolism Review reframes regulated cell death (RCD) through a metabolic lens, arguing that metabolism is not simply a consequence of dying cells but the gatekeeper that determines whether, when, and how cells die.

Rather than viewing apoptosis, ferroptosis, necroptosis, and pyroptosis as isolated signaling pathways, the authors propose a metabolic continuum in which cellular bioenergetics, redox state, lipid composition, and metal availability establish permissive or restrictive conditions for specific death programs.

Four major metabolic checkpoints

⚡ Energy

ATP availability licenses apoptosis.
Energy collapse shifts cells toward necrotic or lytic death.

🧪 Redox

NADPH, glutathione (GSH), GPX4, CoQ10 and FSP1 determine resistance to oxidative stress.
Collapse of antioxidant buffering promotes ferroptosis.

🫧 Membrane lipid composition

Polyunsaturated phospholipids increase ferroptosis susceptibility.
Monounsaturated lipids provide protection.
Membrane architecture also regulates pyroptosis and necroptosis.

⚙️ Metal homeostasis

Iron drives lipid peroxidation.
Copper triggers cuproptosis.
Selenium supports GPX4 activity.
Zinc modulates caspase function.

The review also emphasizes that organelles function as metabolic decision hubs rather than isolated structures.

🟠 Mitochondria
Control ATP production, ROS generation, cytochrome c release, apoptosis, ferroptosis and inflammatory signaling.
🟢 Endoplasmic reticulum
Coordinates lipid remodeling, calcium flux, unfolded protein responses and ferroptosis susceptibility.

🔵 Lysosomes
Regulate autophagy, ferritinophagy, lipophagy, iron release and ferroptotic sensitivity.
Communication between these organelles creates spatial metabolic networks that ultimately determine cell fate.

Perhaps the most important conceptual advance is the idea that death pathways are plastic.
The same trigger may induce:

• Apoptosis in metabolically competent cells

• Necroptosis after ATP depletion

• Pyroptosis during inflammatory metabolic rewiring

• Ferroptosis when lipid peroxide buffering fails

In other words, metabolism determines which death program is accessible.

This framework has broad translational implications.

Instead of targeting death executors alone, therapies could manipulate metabolic checkpoints—bioenergetics, lipid remodeling, redox buffering or metal handling—to redirect cell fate in cancer, neurodegeneration, inflammation and tissue injury.

As spatial metabolomics and organelle-resolved imaging mature, metabolism is poised to become the central organizing principle linking stress adaptation, cell survival and regulated cell death.

Reference: The metabolic basis of regulated cell death. Cell Metabolism (2026).

#CellDeath #Metabolism #Ferroptosis #Apoptosis #Pyroptosis #Necroptosis #Cuproptosis #CancerBiology #CellMetabolism #Mitochondria

[Martin Picard @MitoPsychoBio]

Mitochondria are transferred between cells, tissues and organs, particularly in response to stressors

New exciting layer of mitochondrial biology showing the importance of cell-cell interactions and that mitochondria convey information/signal widely

https://t.co/iHWXHVF34o

🧵

[Frontiers for Young Minds @FrontYoungMinds]

Grid cells are a specific type of neuron that is essential for the brain’s 🧠 navigation system. @NobelPrize winner Edvard Moser describes exciting new advances since he discovered grid cells and how this could help us understand the brain and how cognition works.

Read more ⬇️

[Shubha Tole (she/her) @shubhatole]

Spot on predictions

[Dr Asma Jabeen @DrasmaJabeen1]

Writing research articles for publication

[Dr Asma Jabeen @DrasmaJabeen1]

Research proposal flowchart #research #academia

[Latest in space @latestinspace]

What does the Cone Nebula look like to you?

[Sanjeev Galande @SanjeevSaGa]

Whoa - Motivation to perform long-term physical activities is not exclusively driven by brain but is, as this study in mice demonstrates, dependent on the gut bacteria!
https://t.co/f4ZD7e6QPn
@Nature

https://t.co/hnGyyUSv4d

[Prof. Feynman @ProfFeynman]

If you cannot be corrected without being offended, then you’ll never truly grow in life. 🧠

[BTS_official @bts_bighit]

A Piece of 'Take Two' - Jung Kook

STAY

Digital Single 'Take Two'
2023. 6. 9. 1PM KST Release

#TakeTwo #JungKook_STAY #JungKook #정국
#BTS #방탄소년단

[Dr Asma Jabeen @DrasmaJabeen1]

How to write a scientific article. Beginners Guide #phd #AcademicTwitter https://t.co/RnTF9xGKnu

[DSTIndia @IndiaDST]

We are happy to share a calendar of "Calls for Proposals" in respect of various #schemes of @IndiaDST for 2023-24. The call opening dates are tentative & therefore, can vary slightly.
The schedule can help you be ready with your #proposals in time.

🔗https://t.co/O0MdYgp19y

[Hugo Chrost @chrost_hugo]

An animation showing how we hear sounds.

Credits: design_cells

#MedTwitter

[Chayanika Banerjee @Chayanika_Baner]

@anita_goyala Congratulations di !!

[The Nobel Prize @NobelPrize]

"Freedom is choosing your responsibility. It's not having no responsibilities; it's choosing the ones you want." – Author Toni Morrison.

Morrison became the first African American woman to be awarded a #NobelPrize when she received the 1993 literature prize.

[United Nations @UN]

Globally, nearly 1 in 6 deaths are due to cancer.

The good news is that 40% of them are preventable.

On Saturday's #WorldCancerDay, @WHO shares key facts & tips to reduce cancer risk. https://t.co/nwxN31SkML

[The Nobel Prize @NobelPrize]

The gene editor CRISPR-Cas9 is contributing to innovative cancer therapies and may make the dream of curing inherited diseases come true.

Emmanuelle Charpentier and Jennifer Doudna received the 2020 chemistry prize for their research on CRISPR/Cas9.

#WorldCancerDay

[Chayanika Banerjee @Chayanika_Baner]

@smartelegans @Emi_Garg @KulkarniMj @Dsreddy88 @serbonline @DBTIndia @NImmunology Congratulations !!