Chris Lawrence

Forensic Psychiatrist, gets strangely passionate about antipsychotic doses. Views are my own.

[Chris Lawrence @ChrisL8888]

@SHFT_Research

[Chris Lawrence @ChrisL8888]

New paper! [A 🧵 1/6]

APP and HDAT compared to antipsychotic monotherapy at standard doses in schizophrenia – a systematic review - Christopher Lawrence, Chloe Roberts, Chloe Galides, Samuel R Chamberlain, Ruihua Hou, 2024 https://t.co/WZXqFPMKE6

[Chris Lawrence @ChrisL8888]

Clozapine does not work for everyone, but if we are going to continue trying APP and HDAT, we need some more high-quality large-scale RCTs to find what works [end 🧵6/6]

[Chris Lawrence @ChrisL8888]

Treatment resistant schizophrenia, by definition, is hard to treat. 5/6

[Chris Lawrence @ChrisL8888]

So why do clinicians continue to prescribe in this way? 4/6

[Chris Lawrence @ChrisL8888]

Interestingly, lack of tolerability of either approach was unclear, but that may well be because the longest follow up period was 24 weeks 3/6

[Chris Lawrence @ChrisL8888]

We found very little evidence for the efficacy of APP and HDAT in the treatment of schizophrenia over the use of antipsychotic monotherapy at a standard dose. 2/6

[Chris Lawrence @ChrisL8888]

@elcarthy V relatable

[Chris Lawrence @ChrisL8888]

@NathanHuneke @EmmaVaccari @ecnptweets @CorteseSamuele @solmi_marco @UoS_Medicine @SotonPsych Congratulations Nathan!

[Andy Murray @andy_murray]

Never even liked tennis anyway.

[Chris Lawrence @ChrisL8888]

@dr_l_evans I agree, I like to always explain WHY I’ve made a decision rather than just stating the concluding plan. Can’t say anyone has ever praised me for it though 😂

[Barney Ronay @barneyronay]

Going to be a moment in the second half where Harry Kane falls over and either 1. scores the pen to win the tournament and get the golden boot or 2. is sent off

[Dr Rachel Clarke @doctor_oxford]

.@carolvorders YOU ARE BLOODY MAGNIFICENT. EVERY SINGLE WORD OF THIS 🔥🔥�

[Chris Lawrence @ChrisL8888]

@matthoyles @maxrushden @bglendenning @JohnBrewin_ @danbardell @barneyronay @Towno10 we really do need clarity on this please

[Watts Occurring @Watts_Occurring]

Why's nobody following Pog? 👽

@GeraintThomas86 provided a fitting analogy in last night's pod. #Giro

[Nuwan Dissanayaka @nuwandiss]

This is not a general point

For years, the narrative around mental healthcare has ignored a group with psychotic illness who do not engage with services and who, when unwell, have high risks

They need targeted support

They need Assertive Outreach https://t.co/NE6MeoRsPC

[Chris Lawrence @ChrisL8888]

Great work Jamie! Very grateful to have had the opportunity to have contributed to this

[James O'Neill @jamieroneill]

New paper out in Journal of Psychopharmacology

BNF maximum doses for psychosis drugs based on safety, not efficacy. Not for use as guideline / target to achieve clinical response. Point of futility often much lower @DrSamMcLean @adamjameson96 @ChrisL8888

https://t.co/HecyriWfpT