Very excited to see my main postdoctoral research project peer-reviewed and published! We used cryoEM and biochemical experiments to uncover how Polymerase θ helicase facilitates DNA microhomology annealing to repair DNA in BRCA-deficient cancers. Paper: https://t.co/YNQ0FvoL5i
A DNA repair enzyme that some cancers rely on to survive could be the key to more precise treatments. The @LanderLab has captured the first images of Pol-theta in action, revealing how it repairs DNA—offering a blueprint for better cancer therapies.
More: https://t.co/sFKwXTUFUW
Thrilled to share my postdoctoral work in @Landerlab! The human Polymerase θ helicase undergoes conformational rearrangements to facilitate DNA microhomology annealing. These insights enable rational design of novel BRCA-deficient cancer therapeutics! https://t.co/DWsLxdJtah
Our first foray into the fascinating field of DNA repair! Congrats to postdoc Chris Zerio @chriszerio, who tested hundreds of oligos to identify one that trapped the helicase of human Polymerase θ in the process of annealing two strands of DNA. https://t.co/vKldWuTd8x
A compilation of photos from the past couple of days at the @CSHL Cryo-EM course! Late night data processing, manual plunging grids, and clipping grids! @cshlcourses#CryoEM@LanderLab@chriszerio
Scientists led by @LanderLab uncover a critical feature that a promising new class of #cancer drugs needs to be effective. These drugs need to cause specific shape changes in their target that can then trigger the breakdown of key cancer-driving proteins https://t.co/6WakQ78gkk
Fantastic talk by @ChrisZerio who is off to postdoc for @LanderLab in what is apparently the greatest EM lab 😊😊. He did a wonderful job with his talk, his acknowledgments were incredible. It was a treat!!!
.@ChrisZerio had an incredible 4-yr career with the Loggers: 3x All-NWC selection and an All-West Region honoree. He has the second-best career BA in Logger history at .370. A stellar student Zerio is working on his PhD in Pharmaceutical Sciences at the Univ. of Arizona.#LoggerUP