#Cloisonné, also known as copper-body filigree enamel, is a treasure of traditional Chinese arts and crafts. It was inscribed on #China's first batch of National Intangible Cultural Heritage List in 2006. Click the video to watch how cloisonné is made!
Video via Douyin
BEAUX CHÂTEAUX DE FRANCE 🇫🇷🏰
Si vous avez l'occasion de passer en Auvergne, profitez-en pour faire un détour par le Château de Val.
Son architecture est particulière avec ses nombreuses tours.
Construit au XIIIe siècle, il a été superbement préservé.🤩
[Webinar: Cortico-Cortical Evoked Potentials (CCEPs)] The webinar will take place on Tuesday, June 9, 2026, at 5:00 PM (Central European Time) by Prof. Riki Matsumoto (Kyoto, Japan) on “Cortico-Cortical Evoked Potentials: Fundamentals and Clinical Applications”. https://t.co/ue47v492GA
Micro- and Nanoplastics as Emerging Drivers of Liver Injury: Exposure, Evidence, and Mechanisms
▶️ Growing evidence suggests that, following ingestion, inhalation, or, less convincingly, dermal exposure, MNPs may cross biological barriers, enter lymphatic & vascular compartments, & reach the liver.
▶️ MNPs may induce hepatic injury through oxidative stress, mitochondrial impairment, endoplasmic reticulum stress, inflammation, DNA damage, dysregulated lipid metabolism & disruption of the gut–liver axis, consequently contributing to steatosis, cholestatic anomalies & fibrosis
https://t.co/8ycgsohSCk @DHPSP@_atanas_@drfherediaz@DrRPalmquist@malaga1711@DrGrimaldesJ@tatiann69922625
Schematic summary of mechanisms of micro- and nanoplastic-induced liver injury
The Musée d’Orsay is housed in a former railway station built for the 1900 Exposition Universelle. Its huge glass roof and iron arches make it one of the most striking museum settings in Paris. The station was nearly demolished in the 1970s before being transformed into a museum that opened in 1986.
Inside you’ll find the world’s largest collection of Impressionist and Post-Impressionist art, with paintings by Monet, Renoir, Van Gogh, and Cézanne. The museum also covers sculpture, photography, and decorative arts from 1848 to 1914. Don’t miss the giant clock windows that look out over the Seine, one of the best hidden views in the city.
📍 Paris 7th arrondissement, Île de France
« La joie de vivre » est l’œuvre d’Émile Zola. Une orpheline, élevée au sein d’une famille rongée par l’égoïsme et la maladie, s’efforce de préserver sa bonté. Ce roman nous rappelle que l’espoir, même fragile, peut survivre là où la douleur menace de tout engloutir.
An in vivo and modeling analysis shows that activity of the vagus nerve has a more complex effect on insulin release than was previously thought, hinting vagus nerve stimulation may have unintended metabolic consequences. @KanazawaUniv_O@Tokushima_Univ https://t.co/h7x4FxGIQg
Can we measure Parkinson's disease progression years before diagnosis? An ‘alpha-synucleinopathy’ is a brain disease linked to abnormal accumulation of the protein alpha-synuclein and includes Parkinson's disease, dementia w/ Lewy bodies and multiple system atrophy. Monica Roascio and colleagues describe in a new paper in Brain how clinical changes in REM sleep behavior disorder (RBD) may be tracked years before the emergence of overt Parkinson's disease or dementia.
Key points:
- Using longitudinal data from 766 individuals w/ isolated REM sleep behavior disorder, the authors developed a model that tracks disease progression over time rather than relying on a single conversion event.
- The model identified three markers reflecting earlier or later onset of progression, faster or slower progression, and whether motor or cognitive symptoms emerge first.
- These progression markers were linked to established dopamine imaging biomarkers and to EEG measures of brain network dysfunction.
My take: This study tackles one of the biggest challenges in neurodegeneration. We need better ways to measure progression before a person develops obvious Parkinson's disease or dementia. The traditional approach of waiting for ‘phenoconversion’ may miss many years of meaningful biological and clinical change. Continuous progression markers could ultimately improve clinical trials and help us identify who is worsening and when.
Here are 5 points that resonated w/ me:
1- REM sleep behavior disorder remains one of the strongest known risk states for future Parkinson's disease and related disorders.
2- Motor changes appeared to worsen approximately 35% faster than cognitive changes in this cohort.
3- Clinical progression could be detected many years before traditional diagnostic milestones were reached.
4- Abnormal dopamine transporter imaging and abnormal EEG synchronization were linked to earlier and faster disease progression.
5- The future of disease-modifying trials may depend on continuous progression markers rather than waiting for a binary diagnosis of Parkinson's disease or dementia.
https://t.co/9fGVBXMirL
New Research: Consciousness emerges from temporal integration across biological scales: from cellular memory to phenomenological experience https://t.co/mEIi1dj3nt #FrontiersIn#IntegrativeNeuroscience
🌟Welcome to read the Review:
A Comprehensive Review on the Role of Resting-State Functional Magnetic Resonance Imaging in Predicting Post-#Stroke Motor and Sensory Outcomes by Foteini Christidi et al.
Full-text Available: https://t.co/ClzUUK9Ozg
#fMRI#stroke#motor#RSfMRI
Many cerebellar ataxias remain idiopathic. Could some be immune-mediated?
This elegant @CellCellPress study identifies synaptophysin antibodies in cerebellar ataxia which alter neuronal excitability in vitro
Could these antibodies access the synaptic cleft and drive disease?🤔
Physics in Molecular Biology: This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biolog…
Kim Sneppen, Giovanni Zocchi - Aug 25, 2005
https://t.co/K2HNITgMQF
Recently published in Bioinformatics Advances: "InterProScan 6: A modern large-scale protein function annotation pipeline"
Find it here: https://t.co/tFzmFakSjv
Authors include: @Alexbateman1
Aging and mental health are deeply connected. Promoting emotional well-being, cognitive resilience, and healthy aging is essential for improving quality of life across generations.
Join the discussion at ICBSSR 2027 | Feb 10–11, 2027 | Miami, USA (Hybrid Event)
#ICBSSR2027