Clelland Lab

We are developing novel CRISPR gene editing therapies for neurodegenerative diseases, first focusing on FTD and ALS caused by single gene mutations.

[Clelland Lab @ClellandLab]

Follow us @clellandlab.bsky.social

[Clelland Lab @ClellandLab]

https://t.co/wLUMFP6ZI2

[Clelland Lab @ClellandLab]

C9orf72 repeat expansions are difficult to measure. This paper describes a protocol utilizing the CRISPR/Cas9 system and PacBio single-molecule sequencing to accurately sequence repeat expansions without amplification, overcoming the limitations of traditional methods.

[Clelland Lab @ClellandLab]

Single molecule sequencing helped us overcome the challenge of working with long repeat expansions.

https://t.co/xOqxSbrmDL

[Clelland Lab @ClellandLab]

It takes a village of patients, families, scientists and clinicians to get new and groundbreaking therapies to clinical trial. Thank you for creating this village with us!

[Clelland Lab @ClellandLab]

We are so grateful to Dave Shulman and his supporters for helping to accelerate our efforts to treat and cure ALS and FTD.
https://t.co/1AsU2WTUZ1

[Clelland Lab @ClellandLab]

Big thanks to @hoperhenderson for the fantastic write-up! 🙌🏼 Congrats to the Clelland Lab for the groundbreaking work! 🎉 #C9orf72 #CRISPR
https://t.co/Cyca2mPrES

[Clelland Lab @ClellandLab]

Looking forward to @jacksonlab and @ChanZuckerberg's Engineering Induced Pluripotent Stem Cell symposium, highlighting genome editing technologies in #iPSC neurological disease modeling methods.

Join me May 6th: https://t.co/FEr0nbj3dZ

[Clelland Lab @ClellandLab]

Our paper on developing CRISPR gene therapy for #C9orf72 FTD/ALS is out in @PNASNews - check it out!
https://t.co/P8XcLPTI1N

[Clelland Lab @ClellandLab]

CRISPR gene therapy for the brain and spinal cord: What is it, why isn't it a reality yet and what needs to be done to bring it to the clinic. Check out our latest @JAMANeuro review article:https://t.co/z9icOuzy93

[Clelland Lab @ClellandLab]

Our perspective on CRISPR for the CNS was just published @JAMANeuro . Find it here:https://t.co/z9icOuzy93. Congrats to Dr. Salomonsson on such a well-written and easy to read piece!

[Clelland Lab @ClellandLab]

Our latest research on creating validated methods for neurodegenerative research, #C9orf72, CRISPR outcomes is now available @SciReports . Read here: https://t.co/4ZBtM2BjFC

[Clelland Lab @ClellandLab]

Our latest research on #C9orf72 human DNA, RNA, protein quantification methods is published: https://t.co/4ZBtM2BjFC. Well done to the team of talents post-docs and post-baccs who made this work possible and special thanks to @PacBio for their collaboration.

[Clelland Lab @ClellandLab]

Read our latest #research on #C9orf72, published with @SpringerNature in @SciReports. Check it out!
https://t.co/tPsPPOUN8u

[Clelland Lab @ClellandLab]

@Jeanc9orf72 @UCSFmac @NIH @NINDSdirector Thank you for being so open with your experience and perspective on medicine!

[Clelland Lab @ClellandLab]

Thank you @Jeanc9orf72 for sharing your experience as a C9 carrier, family member, and activist. Hearing patient stories is so important for scientists, and we really appreciate the work you are doing!

[UC San Francisco @UCSF]

Congratulations to this year’s Nobel Prize in Chemistry awardees, including UCSF postdoc alum Carolyn Bertozzi.