What really happens when patients stop GLP-1s like semaglutide or tirzepatide?
A new systematic review & meta-analysis in Obesity Reviews has answers—and they’re critical for anyone treating obesity as a chronic disease.
TLDR: "Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to obesity."
Key findings:
After stopping liraglutide, patients regained ~2.2 kg ⚖️
After stopping semaglutide/tirzepatide, patients regained ~9.7 kg ⚠️
Weight regain was proportional to initial weight loss
Lifestyle changes alone did not prevent regain
Implication:
GLP-1 receptor agonists are not a short-term solution.
If the goal is durable weight loss and risk reduction, stopping therapy may reverse progress.
We don’t stop:
Antihypertensives when blood pressure normalizes
Statins when LDL improves
Why treat obesity differently?
This study reinforces what many of us already know:
Obesity is chronic. GLP-1 therapy should be chronic too.
Let’s treat it that way.
Full article: https://t.co/sqKxsLe2lI
What a disappointing start to my @WHOOP experience. I
Finally pulled the trigger and ordered my Whoop. I dutifully paid the £9.99 for 3-5day shipping 😳. Only to be sat here on day 5 with the courier yet to revive it! Very very big let down.
📢 Further Education (FE) colleges are vital for equipping young people with the skills our economy needs, yet staff shortages and pay disparities compared to other parts of the education sector hinder progress.
The government must close pay gaps and support the FE workforce!
https://t.co/SapdiXeST8
#FEchat #FurtherEducation
Surreal. Ed Conway's analysis shows that even after Rishi Sunak's proposed tax cuts, taxes will reach a new 80 year high!
Every time someone says the Conservatives are cutting taxes in this manifesto, show them this analysis
So you thought we’d reached Peak Brexit? Watch British Paratroopers who after being dropped into Sannerville, France, to commemorate D-Day, had to show their passports to the French Douane…
@Nigel_Farage musty be so proud…
You don’t really get bigger Tory fanboys than Montgomerie & here in real time, he’s informed why Sunak left the D-Day commemorations early…
Wait till he realises, IT ISN’T EVEN BEING AIRED UNTIL NEXT WEEK!
Sunak’s not just toast… he’s charcoal. #newsnight#GeneralElection