Prof Peter Collignon

Infectious Diseases Physician and Microbiologist. Professor Medical School. Australian National University. Views are my own.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Linezolid shows promise for the treatment of early syphilis!
Dose and duration matter!
Trep-AB Study lancet 2024:: Oral linezolid at a daily dose of 600 mg for 5 days did not meet the non-inferiority criteria compared with BPG
🆕💥🟢 OFID: randomized, non-comparative pilot study utilizing an experimental group & a contemporaneous control group of Linezolid 600mg q12h for 10d for Early Syphilis Treatment #IDXposts https://t.co/a33Be6Sp0t

[Michael Mina @michaelmina_lab]

Wow… The Babies are No Longer Protected Against Measles

Moms antibodies used to give 6-9 months of Ab protection to infants

Now, protection is gone by ~4 months
Neutralizing Ab titers = 0 by 6m

And… if we give MMR early to fill the gap it can drive a long-term problem

1/

[Simon Kuestenmacher @simongerman600]

I don’t consider this good news. Growth is essential for China’s internal stability. An unstable is more likely to act irrationally. Also, I live in a country that sells lots of resources to China…

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

When these 2 antibiotics entered the market, we were taught:
🔹 Ceftolozane-tazobactam (C/T) = Pseudomonas aeruginosa, particularly DTR
🔹 Ceftazidime-avibactam (CZA) = CRE
But is this distinction accurate?
🆕 💥🟢ATLAS Global Surveillance Program 2020–2024
🔺Among 39,661 global P. aeruginosa isolates:
🔹 90.6% were susceptible to CZA
🔹 89.8% were susceptible to C/T
🔺Among carbapenem-resistant isolates, 68.0% were susceptible to CZA vs 65.6% to C/T
🔺A DTR phenotype was present for 8.0% of isolates; 30.4% and 28.5% of DTR isolates were CZA S and C/T-S, respectively
#IDXposts @BradSpellberg
https://t.co/x8JgFrSo0O

[Simon Kuestenmacher @simongerman600]

This chart probably mirrors your felt experience since 2016 pretty well…

[Simon Kuestenmacher @simongerman600]

Good news: US opioid deaths halved over the last 4 years.
Bad news: They still kill more than one Stamford Bridge (44,564) worth of people.

Source: https://t.co/NW8OgpqYEH

[Isaac Bogoch @BogochIsaac]

Zoonotic infections are increasingly common.

While this is the first identified human case there are likely to be more (both mild & possibly more serious) that have gone undetected.

Such illnesses remain under-diagnosed due to a lack of diagnostic tools/clinical consideration.

[Our World in Data @OurWorldInData]

No matter what poverty line you choose, the share of the global population below it has declined.

The World Bank's International Poverty Line is an extremely low poverty line. Set at $3 per day, it draws attention to the living conditions of the poorest people on the planet.

In the chart above, you can see how the share below this poverty line has declined over the last generation. In the year 2000, 36% of the world’s population lived on less than $3 per day. In 2024, it was 10%.

But is progress against global poverty only happening when measured against such a very low poverty line?

The chart gives the answer. The entire blue line is below the entire dark red line. This tells us that no matter what line you choose, the share below it has declined globally.

Progress against higher poverty lines has been large, too. The share living on less than $5 a day has declined from 57% to 25%, and the share living on less than $10 a day has declined from 74% to 53%.

But on the right-hand side of the chart, we see that most people still live on low incomes: 81% of people in the world live on less than $30 a day, or about $900 a month.

(written by @MaxCRoser)

[World of Statistics @stats_feed]

🥜 In 2000, to prevent peanut allergies, the American Academy of Pediatrics recommended children zero to three years old to avoid them, which backfired, and caused peanut allergy cases to grow dramatically.

[Paul C of 🏴󠁧󠁢󠁥󠁮󠁧󠁿 och 🇸🇪 @dobssi]

@karamballes You might want to look at their excess mortality.

https://t.co/B3GDd4yIOe

[World of Statistics @stats_feed]

Waymo’s robotaxis had 95% fewer serious crashes than human drivers over 271 million miles with no one in the driver’s seat.

Their data also shows:
• 82% fewer injury crashes overall
• 93% fewer pedestrian injury crashes
• 86% fewer cyclist injury crashes

An independent IIHS study found similar big reductions.

They’re reportedly planning to grow from ~4,000 cars to 20,000 by the end of 2027.
Safer so far, the real test is whether it holds as they scale.

[Simon Kuestenmacher @simongerman600]

Being 20 ain’t easy…

[Prof Peter Collignon @CollignonPeter]

Heart disease deaths were higher during Covid years but then dropped fairly quickly to baseline. Was it the infection? Or the effects of restrictions?

[Eric Topol @EricTopol]

Heart disease deaths are on the rise in the US

[Crémieux @cremieuxrecueil]

Researchers gave 2,000 unemployed people €560/month for two years and tracked them to see how they differed from otherwise eligible nonrecipients.

They didn't do any more or less crime. Nothing changed.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥🟢Meta-analysis of randomised controlled trials
10 RCTs
Short-course versus long-course antibiotics in bone infections
🔺The ITT analysis showed no statistically significant difference in treatment failure between short- and long-course antibiotic therapy, while short-course therapy was associated with significantly fewer antibiotic-related
#idxposts
https://t.co/uLGztXV2iP

[Simon Kuestenmacher @simongerman600]

Social activities keep declining in the US. Going to rock and pop concerts is up - I’d guess that’s because older folks can afford tickets to see their teenage favorites?

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Does clarithromycin modulate circulating inflammatory proteins in CAP?
🆕💥🟢Secondary analysis of the ACCESS trial
🔺Clarithromycin shows measurable immunomodulatory effects in CAP
🔺Clarithromycin treatment was associated with selective IL6 suppression.
🔺Clarithromycin treatment decreased the risk of death among patients of the pro-inflammatory cluster #idxposts
https://t.co/UpGJN50SHu

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Prior Antibiotic Exposure and Subsequent Resistance in the Individual Patient
🆕💥🔴Progressing From Association to Causation: Examining Prior Antibiotic Exposure and Antimicrobial Resistance Across 3 US Health Systems Using Causal Machine Learning
Prior antibiotic exposure was consistently associated with increased same-class nonsusceptibility across antibiotic classes and health systems, paralleling higher rates of microbiologically inactive empiric therapy #idxposts https://t.co/VC5q4PRXI6

[Paul C of 🏴󠁧󠁢󠁥󠁮󠁧󠁿 och 🇸🇪 @dobssi]

@Derithomas Indeed. But not surprising sadly.

[Paul C of 🏴󠁧󠁢󠁥󠁮󠁧󠁿 och 🇸🇪 @dobssi]

Stay safe out there Londoners - there are 7 ( SEVEN ) confirmed cases of Covid19 in Islington right now!