Cory Simpson, MD, PhD, FAAD (he/him)

Physician-scientist @UWMedicine @DermatologyUW focused on advanced microscopy, keratinocyte biology, teledermatology, and genetic/autoimmune blistering disease.

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: https://t.co/Ko48RnTxNp

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Excited to be representing @SimpsonLabUW in sunny 😎 San Diego 🌴 for #ASCB2024 #CellBio2024 @ASCBiology

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Starting the migration to the other place, using handle @SimpsonLabUW …hoping to find the old #sciencetwitter and #dermtwitter crowds.

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Proud of med student Rafael Homer whose summer research project @SimpsonLabUW @DermatologyUW won 2nd place in the @uwsomwwami Wyoming site poster competition! Rafael also won a travel award to attend the Western Medical Research Conference & was chosen for an oral presentation🤩

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

@drhankopelman Agree "Research Fever" is out of control in Derm (https://t.co/SWqSdGhbn0). Your reference cites NRMP so I think they include abstracts+presentations. I advise applicants not to get discouraged by the stats. Many inflate their number w/rotation talks & case reports "in progress."

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

@drhankopelman Great advice overall but “25+ papers” should be clarified unless you have other data. The NRMP stats I saw lump together abstracts, presentations & pubs. Abstracts/presentations are way faster and inflate the total. I worry about perpetuating imposter syndrome with the 25+ stat.

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Exciting week @SimpsonLabUW @DermatologyUW celebrating🍾our newest paper @JCI_insight (see separate🧵). which uncovered a mechanism that drives the pathology #Grover disease and was reversed using MEK inhibitors. Special thanks to Arti for making an amazing Indian lunch buffet!

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: https://t.co/Ko48RnTxNp

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

@CterminiPhD @TheVFoundation @fredhutch Great news! Congratulations🍾

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Hope this will finally move the needle for severe drug reactions like SJS & TEN, nightmare consults in #dermatology. No Rx has great evidence to halt skin/mucosal sloughing that can be fatal. JAKi remains to be rigorously tested in patients/RCT but could change standard of care.

[UCISkin @UciSkin]

Spatial proteomics identifies JAKi as treatment for a lethal skin disease | Nature https://t.co/zolcG4Ysi0

[nature @Nature]

Nature research paper: Spatial proteomics identifies JAKi as treatment for a lethal skin disease https://t.co/PWWIX8ua58

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

This program has been an outstanding opportunity for networking with peers, receiving grant feedback, learning how to navigate the new PI path, and getting sage career advice from leading physician-scientists. 10/10 highly recommend @the_asci. Consider applying

[ASCI @the_asci]

Early-Faculty Physician-Scientists!

Nominations are open for the ASCI Young Physician-Scientist Awards.

Award Benefits include access to @JointMeeting, networking and career development opportunities.

Deadline: Oct. 23

More info: https://t.co/yz0SAfJR7u

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Proud of all co-authors & grateful to our collaborators @umichmedicine & @PennSbdrc including @drdremchu. Thanks to @NIH_NIAMS & @FIRST_Skin for lab support and @LEOFondet for funding my effort to find shared mechanisms & treatment strategies for rare skin #blistering diseases.

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: https://t.co/Ko48RnTxNp

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Finally, we reasoned the same mechanism could drive spontaneous Grover disease (ie, not drug-induced). Accordingly, we found ERK hyper-activation in Grover disease lesions and propose MEK inhibitors may be therapeutic for this idiopathic disorder lacking any FDA-approved therapy.

[ASCI @the_asci]

Early-Faculty Physician-Scientists!

Nominations are open for the ASCI Young Physician-Scientist Awards.

Award Benefits include access to @JointMeeting, networking and career development opportunities.

Deadline: Oct. 23

More info: https://t.co/yz0SAfJR7u

[Cory Simpson, MD, PhD, FAAD (he/him) @CorySimpsonMD]

Great lunch @SimpsonLabUW⁩ ⁦@DermatologyUW⁩ for lots of celebrating including Arti’s birthday 🥳 More good news to share soon now that I’m out from under the cloud of this R01 submission 😮‍💨📝 ✅🤞