Cristina Lao-Peregrin

Analyst on therapeutics (CNS).Neuronal plasticity. BDNF lover and amateur painter🎨 #biopharma #therapeutics

[Cristina Lao-Peregrin @CrisMLP]

Start the year learning about TrkB and mGluR5 teaming up in the hippocampus, choreographing synaptic changes. BDNF and G-protein-dependent crosstalk lead the intricate dance of receptor crosstalk. Thanks to everyone that made it possible #trkb #gpcr https://t.co/363XX2O27O

[Cristina Lao-Peregrin @CrisMLP]

Given the co-expression of TrkB and mGluR5 in the nervous system and their roles in synaptic plasticity. The enhancement of TrkB-driven synaptic plasticity by mGluR5 positive allosteric modulators offers promising avenues for advanced antidepressant treatments.

[Cristina Lao-Peregrin @CrisMLP]

I am happy to share a pre-print about my project at at Dr. Francis Lee's Lab on a novel form of synaptic plasticity. Please don’t be shy and share your feedback. All this work was possible to an amazing team, thanks to @JihyeKimMD and the rest of the team
https://t.co/sp1SJNKOoo

[Cristina Lao-Peregrin @CrisMLP]

1. Our research describes a new RTK/GPCR crosstalk wherein mGluR5 amplifies TrkB effects to modify downstream signaling dynamics, leading to a unique form of BDNF-induced synaptic plasticity.

[Cristina Lao-Peregrin @CrisMLP]

1. The identified crosstalk between TrkB and mGluR5 is facilitated through the cooperative action of Gbg, released from TrkB, and Gaq-GTP, released from mGluR5. This represents a novel and physiologically significant form of RTK/GPCR crosstalk.

[Cristina Lao-Peregrin @CrisMLP]

2. This interplay results in a distinct form of BDNF-induced synaptic plasticity characterized by sustained, oscillatory Ca2+ signaling and enhanced MAP kinase pathway activation.

[Cristina Lao-Peregrin @CrisMLP]

Proud to be part of this team 🥰

[Francis Lee @DrFrancisLee]

During #MHAM, I honor the countless hours of my lab team. We take a multidisciplinary approach to studying the function and dysfunction of neural circuitry with a particular focus applying this work to the progression & treatment of psychiatric disorders. Thank you!

[Cristina Lao-Peregrin @CrisMLP]

@DrFrancisLee Proud to be part of this team 🥰

[News from Science @NewsfromScience]

A class of #Alzheimers drugs that aims to slow cognitive decline, including the antibody lecanemab that was granted accelerated approval in the United States in January, can cause brain shrinkage, researchers report. https://t.co/8uvEuZHCOG

[The Nobel Prize @NobelPrize]

Happy International Women's Day!

We're celebrating women who have changed the world. Here's all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award.

Who are the women who inspire you the most?

#IWD2023

[Matt Hill @canna_brain]

Honored and excited to take on this Chair and advance our understanding of the relationship of physical and emotional trauma to mental health.

[U Calgary @UCalgary]

#UCalgary announces Dr. Matthew Hill as inaugural Chair of Mental Health Initiative for Stress and Trauma, exploring how the brain reacts to physical and emotional stressors https://t.co/ccL06lzy8O @HotchkissBrain @UCalgaryMed @UofCr4kids

[HDBuzz @HDBuzzFeed]

Wow - Roche has announced that in addition to a new trial of tominersen, it is working on TWO different approaches - a small molecule huntingtin splicing modulator (a bit like PTC518) and a mutant-only huntingtin-lowering ASO (like the Wave approach)

[WCM Office of the Research Dean @WCMResearch]

Congratulations to Dr. Francis Lee on his appointment as the new interim Stephen and Suzanne Weiss Dean of Weill Cornell Medicine! @wcmresearch #weillcornellmedicine #werechangingmedicine

[Science Magazine @ScienceMagazine]

Anthony Fauci has become one of the most recognizable physician-scientists in the world.
For a new #ScienceEditorial, @hholdenthorp sat down with the outgoing #NIAID director to talk about the challenges facing science and his plans for the future. https://t.co/YH4Zzcmwhk

[Cristina Lao-Peregrin @CrisMLP]

@RevNeurol https://t.co/bZOdvPZHXg

[The Rajadhyaksha Lab @RajadhyakshaLab]

Please RT. #Postdoc and Research Tech positions open @RajadhyakshaLab to study #addiction in animal models. Genetics, molecular, circuits, behavior. DM me.

[GranadaOnline ® @GranadaOnline]

🔴 Irrespirable + peligroso el aire y humo ahora mismo en Granada 😷
#Incendio #Granada #Guajares

[Neuroscience News @NeuroscienceNew]

Epstein-Barr Virus May Be Leading Cause of Multiple Sclerosis

The risk of developing mutliple sclerosis increases 32 fold following Epstein-Barr virus infection.

#multiplesclerosis #neuroscience #science #neurology

https://t.co/TFbxbhDtNy

[Science Magazine @ScienceMagazine]

A new Science analysis of data from U.S. military recruits suggests multiple sclerosis—a disease considered of unknown etiology—is a complication of infection with Epstein-Barr virus.

Learn more ⬇
https://t.co/cxayFOyU9n
#SciencePerspective: https://t.co/DJvxFxMc5X