DIRECT project

DIRECT is a European research project looking at type 2 diabetes. It is funded by IMI-JU

[Adem yesuf @Ademyesuf]

Findings supported by eQTL and in-vitro functional studies and clinically actionable drug-drug-gene interactions with statins. @DIRECTdiabetes @MetGen @UoDMedicine @ezpearson @KsMoneeza @UoDOpenResearch #type2diabetes #pharmacogenomics #PrecisionMedicine

[DIRECT project @DIRECTdiabetes]

Visit our new website https://t.co/08sEXrvwYS - We will continue to report about the results emerging from our exciting project #diabetes #T2D @IMI_JU #legacy

[DIRECT project @DIRECTdiabetes]

Morgan Obura and Femke Rutters report about a @DIRECTdiabetes #MMTT study on “Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes” https://t.co/1H9QEzh2qE @PLOSONE @amsterdamumc @IMI_JU

[DIRECT project @DIRECTdiabetes]

Great work by @RobBizzotto et al deciphering how longitudinal data from @DIRECTdiabetes contributes to the understanding of the factors underlying #type2diabetes progression and processes that might be targets for #PrecisionMedicine in #diabetes: https://t.co/fF5K9gdWRF
@IMI_JU

[DIRECT project @DIRECTdiabetes]

Clusters of co-expressed genes from the blood #transcriptome provide a comprehensive view of #metabolic traits and #T2D - Congratulations to @valborgg @TheBrunakLab and everyone @DIRECTdiabetes #multiomics #type2diabetes @GenomeMedicine

[Valborg Gudmundsdottir @valborgg]

Glad to see our paper on whole blood co-expression modules in @DIRECTdiabetes cohorts published in @GenomeMedicine! We map out, among other things, co-expression module associations with a wide range of clinical traits, T2D, omics and genetics. https://t.co/nstWshsvl5

[DIRECT project @DIRECTdiabetes]

A wonderful contribution of our consortium and investigators Paul Franks, Jurek Adamski and Olaf Pedersen to the work lead by ⁦@segal_eran⁩ on A reference map of potential determinants for the human serum #metabolome | ⁦@nature⁩ https://t.co/O2PDAXwBNH

[Harshal Deshmukh MRCP MPH PhD CCT FRACP @harshaldeshmukh]

Our paper in JCEM. GIPR looks like a interesting drug target for type 2 diabetes. @DIRECTdiabetes study. https://t.co/HN3sCwd0xj

[DIRECT project @DIRECTdiabetes]

Congratulations to @DIRECTdiabetes investigators @dermitzakis @anavinuela and the whole #GTEx consortium on these achievements

[Manolis Dermitzakis @dermitzakis]

Amazing work by @tuuliel and the colleagues! Honored to be part of this amazing consortium!

[Mark McCarthy @markmccarthyoxf]

@DanielJDrucker @jochwenk @ksuhre High throughput experimental & computat/l approaches do not replace the value of detailed dissection of biological & pathophysiological mechanisms, nor the opportunity for serendipity. Used wisely, they augment & empower such efforts, as well as providing entirely new hypotheses

[Jochen Schwenk @jochwenk]

We provide insights into procedures, challenges, considerations and opportunities when combing #genetics and #proteomics for more informed, large scale studies of the circulating #proteome . #biobanks #olink #somalogic #massspec #affinityproteomics #epitopes #causality

[DIRECT project @DIRECTdiabetes]

A new review is out in @NatureRevGenet by DIRECT investigators @markmccarthyoxf and @jochwenk together with @ksuhre on genetics meeting proteomics.

[Mark McCarthy @markmccarthyoxf]

I learned a lot writing this review with @jochwenk and @ksuhre. Hope you'll find something to interest in this tour of the interface between plasma proteomics and human genetics!

https://t.co/OzYZe0mLZR

[Mark McCarthy @markmccarthyoxf]

I learned a lot writing this review with @jochwenk and @ksuhre. Hope you'll find something to interest in this tour of the interface between plasma proteomics and human genetics!

https://t.co/OzYZe0mLZR

[Metabolic Imaging @ImagingFat]

Very happy to see our latest publication from
@DIRECTdiabetes online today. Congratulations to Rebeca Eriksen and @gfrost59 for leading this work: Dietary metabolite profiling brings new insight into the relationship ... https://t.co/w296FtbOv4

[DIRECT project @DIRECTdiabetes]

Already curious about the next @DIRECTdiabetes study? @paulwfranks and team reports in a #preprint on “Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study” https://t.co/tjirjau2XA

[DIRECT project @DIRECTdiabetes]

Another fine study lead by @RobertKoivula and @paulwfranks for our consortium got published! Congratulations and thanks to everyone for making this possible!

[Diabetologia @DiabetologiaJnl]

Twin-cycle hypothesis structural equation models fitted on @IMI_JU @DIRECTdiabetes cohorts support liver fat cycle and show #InsulinSensitivity and #LiverFat mediate association of #PhysicalActivity with glycaemic control @DiabetesLUDC @OCDEM https://t.co/j5sfbkewim 🔓

[Innovative Health Initiative @IHIEurope]

What happens when patients are newly-diagnosed with type 2 #diabetes? Prof Ewan Pearson, a co-lead of our diabetes project @DIRECTdiabetes, explains.

#WorldDiabetesDay2019
#DiabetesAwarenessMonth
#IMICarryTheTorch
@ezpearson
@dundeeuni

[DIRECT project @DIRECTdiabetes]

Exciting progress presented from the analysts working on all the different parts of DIRECT #Diabetes in beautiful #Leiden. #dataintegration #multiomics #treatment #stratification

[Ewan Pearson @ezpearson]

Are you a clinician interested in precision medicine? We have two clinical senior lecturer positions. Any specialty. Focus on health data science, genomics or experimental medicine. @UoDMedicine https://t.co/k7Xf6VKOVy

[Constantinos Parisinos PhD, MRCP @cparisinos]

Final vrsn of our MRI liver iron GWAS in @uk_biobank @DIRECTdiabetes online & #openaccess @JHepatology; Great collab @wellcometrust @uclnews @UCL_IHI @HDR_UK @LiverMultiScan @RCOptimalHealth @UniofExeter @YaghootkarH @profhhemingway @easlnews @RajivJalan1 https://t.co/yyMBVXisaN

[Jochen Schwenk @jochwenk]

Great work @RobertKoivula and @paulwfranks for putting this together for @DIRECTdiabetes https://t.co/8wMkxuFENU