David Lee

Metabolism and stem cells. Old growth forests and lignomics. Also tweet about my puppy.

[Gladyshev Lab @gladyshev_lab]

1/🧵Check out our new publication. “Multi-omic Rejuvenation and Lifespan Extension through Exposure to Youthful Circulation," which has been published in Nature Aging. https://t.co/qVVe5mKpkr

[Aging Science News @AgingBiology]

Multi-omic rejuvenation and life span extension on exposure to youthful circulation
https://t.co/HbX9t0h7We

[The New York Times @nytimes]

A team of scientists has extended the lives of old mice by connecting their blood vessels to young mice. The study found infusions of youthful blood led the older animals to live 6-9% longer, roughly equivalent to six extra years for an average human. https://t.co/mCyVurLMlT

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

More here from David Lee. Data looks solid, look forward to more work including in other animal models ahead.🧑‍⚕️

https://t.co/jscm8E7mZk

[David Lee @DLee133]

@agingdoc1 @davidjglassMD @carlzimmer @nytimes @gladyshev_lab @wysscoray Yancova et al title: “….without positive effect for old”.
Yacova et al data: old iso 1009.4days+/-14.6 vs old het 1063.0+/-34.4, p=0.056.
Titles lie. Lifespan extension data from yancova et al is highly similar to ours (~6%).

[The New York Times @nytimes]

A team of scientists has extended the lives of old mice by connecting their blood vessels to young mice. The study found infusions of youthful blood led the older animals to live 6-9% longer, roughly equivalent to six extra years for an average human. https://t.co/0HGYDcs4N8

[David Lee @DLee133]

@davidjglassMD If you just read the titles, I would agree. The data buried in the paper didn’t warrant to article title, imho. Comparing the raw lifespan data of both models, the heterochronic old groups had remarkably similar degrees of change to median lifespan.

[David Lee @DLee133]

Great working with my co-1st Bohan Zhang! Total superstar! And glad to see Senior author Jim White getting more research out; tough starting a lab doing longevity work cause… well… life happens.

[David Lee @DLee133]

It is (finally) out! Great teamwork on this paper about aging and rejuvenation!

Young circulation is acutely beneficial for an aged organism but thats old news… how long does the system need exposure to young🩸for the benefits to persist?

https://t.co/8ON981XUdd

[David Lee @DLee133]

I was really impressed by that last “mock parabiosis” experiment (suggested during review but buried in Supp Fig 5). Whats the rejuvenation potential of young blood vs increasing physical activity and are those benefits maintained after the intervention is stopped?

[David Lee @DLee133]

And instantly an entire generation of grad students were allowed 4 more hours of sleep.

[Matthew Watt @MattWattUnimelb]

GTTs and ITTs: aim for shorter fasting times | Nature Metabolism- new data suggesting optimal fasting is 2 h for mice. https://t.co/2yQTT81oyx

[David Lee @DLee133]

@SynBio1 And your PE+, GFP-

[David Lee @DLee133]

@MuscleSciMegan @SkepticalDDS

[David Lee @DLee133]

@MuscleSciMegan @SkepticalDDS The person I work with most closely is a dentist and she loves her tooth themed desk things. Like 🦷 pencil holders or 🦷 magnets.

[David Lee @DLee133]

@PhD_Genie “The upfront cost of the real time pcr machine is minimal but requires barcoded plates that expire within three weeks and wont run. Fortunately weve found a work around”

[David Lee @DLee133]

@NIHgrants @NIH “The NIH should score negatively institutions which employ vast numbers of postdoctorates that it doesn’t routinely (or by default) promote into PI/faculty roles. You would think poorly of a master carpenter whose journeymen it wouldnt, once trained, employ to build a house.”

[David Lee @DLee133]

@NIHgrants @NIH “If an institution is willing to employ postdoctoral researchers that it will not promote into faculty positions, the institution is effectively demonstrating it cannot offer research experience to the standard the institution itself sets”

[David Lee @DLee133]

Wait, ill join in on the discussion… I spent just 13 hours on a single R01…….

Table.

[David Lee @DLee133]

Im gunna get in so much trouble when i show this to my statistician wife. 😂☠️