Dimitris Volteras

Computational biology at the Briscoe lab @thecrick. Previously PhD @imperialcollege. Modelling gene regulation in heterogeneous cell populations.

[Dimitris Volteras @DVolteras]

Exciting to see our paper, with @VShahrezaei and Philipp Thomas, now published in @CellSystemsCP! We use stochastic modelling and time-resolved scRNA-seq data to identify global patterns of transcription regulation: https://t.co/1t2PjVemQB

[bianca dumitrascu @bidumit]

How are two embryos alike?

As we collect spatio-temporal microscopy data, we want to quantify variability in the timing of key developmental events.

Alignment of multiple videos is a core engineering challenge here and we have a solution; read about it: https://t.co/0KBCwWSp7a

[Mushtaq Bilal, PhD @MushtaqBilalPhD]

Sci-Hub is an evil website that pirated 85M+ research papers and made them freely available

And now they've added AI to their database to make Sci-Bot.

It answers your questions using latest, full-text articles.

But DO NOT use it. We should all try to make billion-dollar academic publishers richer.

I'm putting the link below so you know how to avoid it.

[Adam Zsolt Wagner @azwagner_]

Really happy to share our new paper on using AlphaEvolve for mathematical exploration at scale, written with Javier Gómez-Serrano, Terence Tao, and @GoogleDeepMind's Bogdan Georgiev. We tested it on 67 problems and documented all our successes and failures. 🧵

[PRX Life @PRX_Life]

Using contrastive learning on noisy trajectories, this method builds coordinate-invariant maps that reveal dynamical regimes, pinpoint bifurcations, and reconstruct phase diagrams, no equations required. #MachineLearning #DynamicalSystems

🔗 https://t.co/JnOrKBH7R6

[Andrew Leduc @_AndrewLeduc]

The big one is finally out!! In this paper, we set out to provide insight into the fundamental question;

How do the individual cells from complex tissues regulate their proteomes?

Brief summary of our findings 👇
https://t.co/4dRXpGJTGn

[nature @Nature]

Nature research paper: Axonal injury is a targetable driver of glioblastoma progression

https://t.co/vASeNr4Wm2

[Biomedical Picture of the Day BPoD @BPoD_s]

Damage to axons in white matter by early glioblastoma (GBM) cells drives progression & spread of this aggressive, incurable brain tumour
#GBM

📹 Melanie Clements, Wenhao Tang, Zan Florjanic Baronik, Holly Simpson Ragdale et al @uclcancer in @Nature
➡️ https://t.co/KjSuemUeFu

[Dimitris Volteras @DVolteras]

@fleetwood___ @anshulkundaje @arcinstitute So how is the goal “to train a model that predicts the effect on a cell of silencing a gene” any relevant to the goal “to train a model that simulates the cell”?

[Anshul Kundaje @anshulkundaje]

One thing that really bothers me with the new "virtual cell" terminology is that is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/

[Yoshua Bengio @Yoshua_Bengio]

Two years ago, I've reoriented my research to try to make AI safe by design. In this @TIME op-ed, I present my team's direction called "Scientist AI"; a practical, effective and more secure alternative to the current uncontrolled agency-driven trajectory.
https://t.co/0sSxNbBGxf

[John J. Vastola @johnjvastola]

Diffusion models generalize *really* well: if you give them a million pictures of cats, they'll learn to generate reasonable-looking cats no one's ever seen before. But the weird thing is that no one knows why they work! In a theory paper accepted to #ICLR2025, I dug into this.

[Development @Dev_journal]

EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in C. elegans

Read this @ReviewCommons transfer article by
@MarFerrandoMar1 & @barkoulab @imperialcollege:
https://t.co/elBdgsmbX7

[Tiago Costa @CostaT_Lab]

With @jrpenades, we challenged AI co-scientist @GoogleAI to generate hypotheses. In just 2 days, it recapitulated our unpublished, experimentally confirmed mechanism for how cf-PICIs spread between bacterial species! 🤯 @imperialcollege @FlemingCentre

https://t.co/hXkZZco6vu

[Andrew Leduc @_AndrewLeduc]

Half the reason mRNA levels may differ from protein levels

[Tom Ellis @ProfTomEllis]

SynBio Turing patterns in E.coli. I've seen this amazing project progress over the last few years at Imperial and excited that it's now published. Well done to all involved! https://t.co/oBJzMmskaW

[Kevin Patrick Murphy @sirbayes]

When did the deep learning crowd first start callling prediction (i.e., forward pass) "inference"? And what should we now call traditional inference (i.e., *inverting* a forwards process)? Should I just call it "posterior inference" (or "statistical inference" if frequentist).

[The Guardian @guardian]

From abortion to immigration, here’s what’s at stake if Trump wins the election https://t.co/HxcUPnJn8i

[Arash Bagherabadi @arash_b_abadi]

🧵 A Thread on “Julia for Biologists” 🧵

1/ Introduction to Julia

A 2023 perspective in @naturemethods highlights #Julia as a powerful programming language for computational biosciences!

🔗 Full article: https://t.co/YIN4qXgvyT

[Candan Celik @candancelik_]

I am pleased to share that our paper entitled "Translation regulation by RNA stem-loops can reduce gene expression noise" has been published in BMC Bioinformatics (@BioMedCentral).

Enjoy reading it freely at:
https://t.co/qNpeICgl91

[Dimitris Volteras @DVolteras]

@kittybmurphy @VShahrezaei Thank you Kitty!😊

[Dimitris Volteras @DVolteras]

I'm thrilled to share that my truly exciting PhD journey has come to an end. It's been a privilege to be supervised by @VShahrezaei and Philipp Thomas, who navigated me through the beautiful world of mathematical and computational biology. I've learned so much. 1/3

[Vahid Shahrezaei @VShahrezaei]

Congratulations to @DVolteras for successfully passing his PhD viva. It has been a pleasure to co-supervise this exciting PhD with Philipp Thomas. Thank you @lpachter and Mauricio Barahona for the examination. Looking forward to Lior's Mathematics Colloquium today @ImperialMaths.