David Yang

Radiation Oncologist at @DanaFarber @BrighamWomens @harvardmed and Research Fellow in @VanAllenLab. All views are my own.

[David Yang @DYangMD]

@HimanshuNagarMD @Adam_Weiner535 @TheLancetOncol Agree with that interpretation! I think a good potential use case could be UIR with goal of avoiding ADT but would need to see how it compares to some form of dose escalation likely microboost

[David Yang @DYangMD]

@CarvalhoFilipeL @OncoBellmunt @KonradStawiski @PereraBel Congrats!

[David Yang @DYangMD]

https://t.co/2vPB9z35bJ

[David Yang @DYangMD]

Excited to share our work on immune microenvironmental features in prostate cancer!

[Eli Van Allen @VanAllenLab]

In our latest, a surprise - thanks to computational pathology - about immune cell clustering in prostate cancer and new ways to understand tumors, their neighborhoods, and clinical outcomes ... congrats @DYangMD et al! (link below)

[David Yang @DYangMD]

Deeply grateful to my coauthors, the patients and loved ones who made this work possible, and @PCFnews for supporting this study 7/n

[David Yang @DYangMD]

Together, our findings nominate immune spatial clustering as a potential biomarker of clinically meaningful immune enrichment in high-grade localized prostate cancer 6/n

[David Yang @DYangMD]

These immune clusters were also associated with molecular features suggestive of a T cell-mediated antitumor response 5/n

[David Yang @DYangMD]

We found that immune cell quantity alone was not associated with outcomes. Instead, a higher burden of spatially dense immune clusters was associated with a lower risk of distant metastasis in two independent cohorts 4/n

[David Yang @DYangMD]

We leveraged deep learning analysis of H&E images (obtained as part of routine care) to evaluate whether immune features were associated with outcomes after prostatectomy 3/n

[David Yang @DYangMD]

Growing evidence suggests that a subset of prostate cancer is immune-enriched, but the clinical consequences of immune enrichment were largely unknown 2/n

[David Yang @DYangMD]

@davidjeinstein Absolutely. cT3a by DRE is not the same as pT3a

[David Yang @DYangMD]

@JoYatesResearch Congrats!

[David Yang @DYangMD]

@HugoAerts Really cool stuff. Congrats!!

[David Yang @DYangMD]

@VincentWenxinXu @YuWeiChenMD @DrChoueiri @DanaFarber_GU @MDAndersonnews @Clara__Steiner @lilli_ash @ChadTangMD @DrYukselUrun @yekeduz_emre @PavlosMsaouel @EUplatinum Congrats!

[David Yang @DYangMD]

@laurasenamd @Adam_Weiner535 @CR_AACR @PCF_Science @AACR @hopkinskimmel Congrats!

[David Yang @DYangMD]

@mouwlab Congrats!

[David Yang @DYangMD]

@JoYatesResearch @VanAllenLab @val_boeva @DanaFarber @CSatETH Congrats!!

[David Yang @DYangMD]

@sjohri20 @NatureComms @VanAllenLab Congrats!!

[David Yang @DYangMD]

@SashaGusevPosts Congrats!!