Daniel Temko

[Jamie Blundell @jrblundell]

Delighted to share a substantially updated preprint led by @gladyspoon1 where we used single-cell derived phylogenetic trees from 80 AML patients to show that pre-leukamic evolution is driven by pervasive positive selection https://t.co/3KaNY88zhR

[Daniel Temko @DanielTemko]

@SamPowerful1 Hard yes

[Daniel Temko @DanielTemko]

@sp_monte_carlo Hmm… yes if one is OK with hypotheticals, I agree. But there’s the rub. What’s a hypothetical. A mysterious possible world? Maybe twitter’s not the right forum for this.

[Daniel Temko @DanielTemko]

So what is probability anyway? Does anyone have an answer satisfied with? Put another way: what does it mean to say there is a 50 percent chance of a coin coming up heads?

[Daniel Temko @DanielTemko]

@nomad421 UMAP has been an integral part of many discoveries from scRNA-seq. It’s a great tool for revealing non-linear patterns at low computational cost. If there was no room for improvement we’d all be out of a job. But not useless!

[Daniel Temko @DanielTemko]

@littmath I spent more hours of my life than I care to admit thinking about a variant of this problem. The answer is "red", and the key to seeing this is to note that the colours of the balls are correlated. So, if you know one ball is red, others are more likely to be red than green 1/2.

[Daniel Temko @DanielTemko]

@littmath I spent more hours than I care to admit thinking about a variant of this problem. The key is to notice that the colours of the balls are correlated, and so if you know one ball is red, others are more likely to be red than green. 1/2

[Dana-Farber’s Breast Oncology Center @DFCI_BreastOnc]

Check out this comprehensive, large-scale, multiplatform, multiomics study recently published in @CellReports on new heterogeneity and transcriptional drivers of #TripleNegativeBreastCancer.
#TNBC #BreastCancer @LabPolyak @DanielTemko @ANewShree @nellage #MylesBrown

[Daniel Temko @DanielTemko]

@nmancuso_ Can you explain what the problem is you’re referring to? A bit odd to specify the distribution of X, but otherwise this looks links a standard linear regression.

[Daniel Temko @DanielTemko]

@ItaiYanai @MartinJLercher Excellent. But is any analysis ever truly hypothesis-free? Maybe a better term would be "hypothesis-light"?

[National Centre for Biological Sciences @NCBS_Bangalore]

How accurate is #histone #inheritance? @Architex_97 & @shaon_chak propose a new model which suggests that the accuracy might be lesser than currently believed.

The pre-print of the study is now available on @biorxivpreprint:

https://t.co/qIxqdwrton

[Michael Nicholson @Mdnicholson3]

New preprint on mutation accumulation in growing populations with David Cheek and Tibor Antal: https://t.co/58xABE4aiA 1/n

[Daniel Temko @DanielTemko]

@yosoykit @trevoragraham @samirguptaGI @AmerGastroAssn Congratulations Kit!

[Daniela Witten @daniela_witten]

Noted and will incorporate into 3rd edition @HastieTrevor @robtibshirani @gareth_m_james

[Jamie Dean @jamie_a_dean]

My Computational Radiation Biology and Oncology Lab
@RadNetCRUKCoL @UCLmedphys @uclcancer will soon advertise for a postdoc to work on mathematical/statistical modelling to optimise drug-radiation combination therapy schedules. DM me to discuss. Please RT. #mathonco #radonc

[Oded Rechavi @OdedRechavi]

Correlation Vs. Causation

[Alex N Nguyen Ba @alex_nguyen_ba]

We developed an experiment to increase the scale of QTL mapping so that we may observe how 'low effect' variants play a role in determining phenotypes. 1/4

[Daniel Temko @DanielTemko]

@BenjaminWerner_ @QMBCI Congratulations Ben!

[Daniel Temko @DanielTemko]

@FryRsquared A tangy delight