Michael Nicholson

Chancellor's Fellow (~Asst. Prof.) @EdinUniMaths | Math modelling for somatic genomics |

[Michael Nicholson @Mdnicholson3]

Happy to share our recent work quantifying ‘just-right’ APC inactivation in colorectal cancer initiation:

https://t.co/K22JYsdP3V

Excellent collaborative teamwork, led by the fantastic Meritxell Brunet Guasch.

[Dr Luke Davis @luke_phys]

Want to work on cutting edge theoretical research to advance our mechanistic understanding of biological processes? Do you enjoy applying ideas from statistical physics and soft matter? I am hiring a 2-year PostDoc at Uni. of Edinburgh. DL: 15/04/2025 https://t.co/CWuu51j13d

[Ramon Grima @ramon_grima]

I have an opening for a postdoctoral research associate in my group at @EdinburghUni to develop new mathematical models of bursty gene expression and signal transduction and fit these to eukaryotic data. Deadline 24th March. https://t.co/7CebLiO8xJ

[Michael Nicholson @Mdnicholson3]

@wchcross @HelenKAlexander Thanks Will, hope everything is good with you

[Michael Nicholson @Mdnicholson3]

#PhD opportunity: fully funded PhD position at the University of Edinburgh on 'Modelling stochastic emergence of antibiotic resistance in bacterial populations' with @HelenKAlexander and myself.

For more info on the project see here: https://t.co/mThgiWV1Oh or get in touch!

[Michael Nicholson @Mdnicholson3]

@jamie_a_dean @UCLmedphys @dfcidatascience @HMS_SysBio @RadNetCRUKCoL @NCIPhySci @Ludwig_Cancer Congrats Jamie, looking forward to giving it a read.

[Michael Nicholson @Mdnicholson3]

Led by the brilliant @xellbrunet. Excellent collaboration with @group_tomlinson; Tibor Antal (@EdinUniMaths); @ISoriano_Moruno; @NathalieFeeley; @drthorn.

Feedback would be most welcome.

[Michael Nicholson @Mdnicholson3]

New paper! Maximally dysregulating APC should provide the maximal selective advantage to colorectal cancer cells? Doesn't appear so.

We quantify 'just-right' APC inactivation, at scale, in a variety of contexts, in our preprint:
https://t.co/jolh5RoIBC

[Michael Nicholson @Mdnicholson3]

@S_J_Aitken Thanks Sarah, looking forward to it. Your suffering through 40 back to back elevator pitches was not in vain.

[Michael Nicholson @Mdnicholson3]

@simocristea Haha, I don't know about that. But thanks Simona.

[Michael Nicholson @Mdnicholson3]

@ASeatonSpatial @EdinUniMaths Thanks, yeah it would be great to catch up. Let me know if you ever venture over to the east.

[Michael Nicholson @Mdnicholson3]

Happy to share that I'll be joining the School of Maths @EdinUniMaths as a Chancellor's fellow (~tenure track assistant prof).

Will be continuing to apply probabilistic thinking to genomics. Very grateful for all support and encouragement I've received.

Come say hi if in town!

[College of Science and Engineering, Edinburgh Uni @ColSciEng]

20 outstanding early career researchers @ColSciEng have received @EdinburghUni prestigious Chancellor’s Fellowships and will begin a 5-year tenure track that invests in researchers delivering cutting-edge interdisciplinary research and innovation https://t.co/nP6BwIvjCP

[Michael Nicholson @Mdnicholson3]

Highly creative, elegant analysis providing deep insights on DNA damage induced mutagenesis. Please do give it a read. Congrats to @craigandersn, @odom_lab, @S_J_Aitken, @mst_paralogue. It was a privilege to contribute.

[Sarah Aitken @S_J_Aitken]

🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today @Nature

Strand-resolved mutagenicity of DNA damage and repair https://t.co/VTP3h139Q4

Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER
[1/13]

[Michael Nicholson @Mdnicholson3]

Great PNAS commentary piece highlighting our recent work on DNA damage:transcription interactions

https://t.co/Yuikjmtmeq

[Giulio Caravagna @gcaravagna]

[https://t.co/HewhGoAiKF] Cancer biomarker discovery is historically mutation-centric, often neglecting the key role of genomics instability. Recently, we asked ourselves how do mutations and copy number alterations (CNAs) determine prognosis and tropism? 😋😋1/n

[Michael Nicholson @Mdnicholson3]

This work has been a fantastic collaboration with Martin Taylor (@mst_paralogue ), Craig Anderson (@craigandersn ), Sarah Aitken (@S_J_Aitken ) and Duncan Odom (@odom_lab ). We'd welcome any comments or thoughts.

[Michael Nicholson @Mdnicholson3]

What happens when RNA polymerases encounters DNA damage during transcription? Excited to see our work out on quantifying the outcomes of such encounters in @PNASNews https://t.co/B1lAf3YpXo 1/n

[Michael Nicholson @Mdnicholson3]

The observed 5' bias in repair efficiency is a consequence of polymerase not restarting, but this pattern wouldn't exist for lower damage burdens. High damage mutation patterns != linear amplification of low damage mutation patterns.